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Protein

Probable phosphoglucosamine mutase

Gene

glmM

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.UniRule annotation

Catalytic activityi

Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Phosphoserine intermediateUniRule annotation
Metal bindingi96 – 961Magnesium; via phosphate groupUniRule annotation
Metal bindingi233 – 2331MagnesiumUniRule annotation
Metal bindingi235 – 2351MagnesiumUniRule annotation
Metal bindingi237 – 2371MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglucosamine mutaseUniRule annotation (EC:5.4.2.10UniRule annotation)
Gene namesi
Name:glmMUniRule annotation
Ordered Locus Names:PH1210
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Probable phosphoglucosamine mutasePRO_0000337824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961PhosphoserineUniRule annotation

Post-translational modificationi

Activated by phosphorylation.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1210.

Structurei

3D structure databases

ProteinModelPortaliO58973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00767. Archaea.
COG1109. LUCA.
HOGENOMiHOG000268680.
KOiK03431.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
HAMAPiMF_01554_A. GlmM_A.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
IPR023666. GlmM_arc.
IPR024086. GlmM_arc-type.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
TIGRFAMsiTIGR03990. Arch_GlmM. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRYFGTSGI REVVNEKLTP ELALKVGLAL GTYLQEGKVV IGCDTRTSSV
60 70 80 90 100
MLKNAVISGL LATGIDVIDI GLAPTPLTGF AIRLYNAEAG VTITASHNPP
110 120 130 140 150
QYNGIKVWDR DGMAYTPDKE HELEKIIESG NFRRVPWNEV GTLKTANPRK
160 170 180 190 200
EYIEAILREI NLKGSYTVVI DAGNGAGSIV SPYLHRELGN RVITLNSDPS
210 220 230 240 250
GFFVRELEPN KESLSMLEKT VKVLNADIGI AHDGDADRVG VVDENGEFVE
260 270 280 290 300
YEVMLSLIAG YMLKKYGKGK IVTTVDAGFA LDDYIRELGG EVVRTRVGDV
310 320 330 340 350
AVAEELVKHG GVFGGEPSGT WIMPQWNLTP DGIFASALVL EMIDRLGPIG
360 370 380 390 400
ELAKDVPKYV TLRKKIPCSN ELKNKVMNKI ADLIPREFSY ERIITIDGIR
410 420 430 440 450
IENDDWWILF RPSGTEPIMR ITLEAHTEEM AERLMKKAEN LVKSVIKDLS

S
Length:451
Mass (Da):49,721
Last modified:June 10, 2008 - v2
Checksum:i0DF52E8A8B2A7B2E
GO

Sequence cautioni

The sequence BAA30310.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30310.1. Different initiation.
PIRiD71064.
RefSeqiWP_048053334.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30310; BAA30310; BAA30310.
GeneIDi1443531.
KEGGipho:PH1210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30310.1. Different initiation.
PIRiD71064.
RefSeqiWP_048053334.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO58973.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30310; BAA30310; BAA30310.
GeneIDi1443531.
KEGGipho:PH1210.

Phylogenomic databases

eggNOGiarCOG00767. Archaea.
COG1109. LUCA.
HOGENOMiHOG000268680.
KOiK03431.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1204-MONOMER.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
HAMAPiMF_01554_A. GlmM_A.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
IPR023666. GlmM_arc.
IPR024086. GlmM_arc-type.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
TIGRFAMsiTIGR03990. Arch_GlmM. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiGLMM_PYRHO
AccessioniPrimary (citable) accession number: O58973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 9, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.