Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O58965

- PGK_PYRHO

UniProt

O58965 - PGK_PYRHO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341Substrate1 Publication
Binding sitei114 – 1141SubstrateBy similarity
Binding sitei154 – 1541SubstrateBy similarity
Binding sitei332 – 3321ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi358 – 3614ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1213-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:PH1218
ORF Names:PHBK036
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Phosphoglycerate kinasePRO_0000146067Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO58965. 1 interaction.
MINTiMINT-1502980.
STRINGi70601.PH1218.

Structurei

Secondary structure

1
410
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi13 – 175Combined sources
Helixi33 – 375Combined sources
Helixi39 – 479Combined sources
Beta strandi51 – 555Combined sources
Helixi70 – 8011Combined sources
Beta strandi84 – 863Combined sources
Beta strandi90 – 923Combined sources
Helixi93 – 1008Combined sources
Beta strandi107 – 1093Combined sources
Helixi113 – 1153Combined sources
Turni117 – 1204Combined sources
Helixi125 – 1284Combined sources
Helixi132 – 1387Combined sources
Beta strandi142 – 1465Combined sources
Helixi149 – 1513Combined sources
Helixi157 – 1604Combined sources
Turni161 – 1655Combined sources
Beta strandi168 – 1703Combined sources
Helixi172 – 18514Combined sources
Beta strandi192 – 1965Combined sources
Helixi201 – 21313Combined sources
Beta strandi218 – 2225Combined sources
Helixi224 – 23411Combined sources
Helixi240 – 2478Combined sources
Turni248 – 2503Combined sources
Helixi251 – 2544Combined sources
Helixi255 – 26511Combined sources
Helixi266 – 2683Combined sources
Beta strandi273 – 2797Combined sources
Beta strandi282 – 2909Combined sources
Helixi291 – 2977Combined sources
Beta strandi301 – 3044Combined sources
Helixi306 – 31712Combined sources
Beta strandi320 – 3267Combined sources
Helixi334 – 3363Combined sources
Helixi338 – 34912Combined sources
Beta strandi350 – 3578Combined sources
Helixi359 – 3679Combined sources
Beta strandi374 – 3763Combined sources
Helixi381 – 3877Combined sources
Helixi393 – 40412Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CUNX-ray2.10A/B1-410[»]
ProteinModelPortaliO58965.
SMRiO58965. Positions 1-405.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58965.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 213Substrate bindingBy similarity
Regioni57 – 604Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiTEYHANT.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58965-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRLEDFNFH NKTVFLRVDL NSPMKDGKII SDARFKAVLP TIRYLIESGA
60 70 80 90 100
KVVIGTHQGK PYSEDYTTTE EHARVLSELL DQHVEYIEDI FGRYAREKIK
110 120 130 140 150
ELKSGEVAIL ENLRFSAEEV KNKPIEECEK TFLVKKLSKV IDYVVNDAFA
160 170 180 190 200
TAHRSQPSLV GFARIKPMIM GFLMEKEIEA LMRAYYSKDS PKIYVLGGAK
210 220 230 240 250
VEDSLKVVEN VLRRERADLV LTGGLVANVF TLAKGFDLGR KNVEFMKKKG
260 270 280 290 300
LLDYVKHAEE ILDEFYPYIR TPVDFAVDYK GERVEIDLLS ENRGLLHQYQ
310 320 330 340 350
IMDIGKRTAE KYREILMKAR IIVANGPMGV FEREEFAIGT VEVFKAIADS
360 370 380 390 400
PAFSVLGGGH SIASIQKYGI TGITHISTGG GAMLSFFAGE ELPVLRALQI
410
SYEKFKEVVK
Length:410
Mass (Da):46,403
Last modified:August 1, 1998 - v1
Checksum:i6912EDE7BD26486E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30318.1.
PIRiD71065.
RefSeqiNP_143113.1. NC_000961.1.
WP_010885305.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30318; BAA30318; BAA30318.
GeneIDi1443540.
KEGGipho:PH1218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30318.1 .
PIRi D71065.
RefSeqi NP_143113.1. NC_000961.1.
WP_010885305.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CUN X-ray 2.10 A/B 1-410 [» ]
ProteinModelPortali O58965.
SMRi O58965. Positions 1-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O58965. 1 interaction.
MINTi MINT-1502980.
STRINGi 70601.PH1218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA30318 ; BAA30318 ; BAA30318 .
GeneIDi 1443540.
KEGGi pho:PH1218.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi TEYHANT.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci PHOR70601:GJWR-1213-MONOMER.

Miscellaneous databases

EvolutionaryTracei O58965.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.
  2. "Crystal structure of phosphoglycerate kinase from Pyrococcus horikoshii OT3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH SUBSTRATE.

Entry informationi

Entry nameiPGK_PYRHO
AccessioniPrimary (citable) accession number: O58965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3