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O58965

- PGK_PYRHO

UniProt

O58965 - PGK_PYRHO

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341Substrate1 Publication
    Binding sitei114 – 1141SubstrateBy similarity
    Binding sitei154 – 1541SubstrateBy similarity
    Binding sitei332 – 3321ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi358 – 3614ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-1213-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:PH1218
    ORF Names:PHBK036
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Phosphoglycerate kinasePRO_0000146067Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiO58965. 1 interaction.
    MINTiMINT-1502980.
    STRINGi70601.PH1218.

    Structurei

    Secondary structure

    1
    410
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 63
    Beta strandi13 – 175
    Helixi33 – 375
    Helixi39 – 479
    Beta strandi51 – 555
    Helixi70 – 8011
    Beta strandi84 – 863
    Beta strandi90 – 923
    Helixi93 – 1008
    Beta strandi107 – 1093
    Helixi113 – 1153
    Turni117 – 1204
    Helixi125 – 1284
    Helixi132 – 1387
    Beta strandi142 – 1465
    Helixi149 – 1513
    Helixi157 – 1604
    Turni161 – 1655
    Beta strandi168 – 1703
    Helixi172 – 18514
    Beta strandi192 – 1965
    Helixi201 – 21313
    Beta strandi218 – 2225
    Helixi224 – 23411
    Helixi240 – 2478
    Turni248 – 2503
    Helixi251 – 2544
    Helixi255 – 26511
    Helixi266 – 2683
    Beta strandi273 – 2797
    Beta strandi282 – 2909
    Helixi291 – 2977
    Beta strandi301 – 3044
    Helixi306 – 31712
    Beta strandi320 – 3267
    Helixi334 – 3363
    Helixi338 – 34912
    Beta strandi350 – 3578
    Helixi359 – 3679
    Beta strandi374 – 3763
    Helixi381 – 3877
    Helixi393 – 40412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CUNX-ray2.10A/B1-410[»]
    ProteinModelPortaliO58965.
    SMRiO58965. Positions 1-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO58965.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 213Substrate bindingBy similarity
    Regioni57 – 604Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiTEYHANT.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O58965-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRLEDFNFH NKTVFLRVDL NSPMKDGKII SDARFKAVLP TIRYLIESGA    50
    KVVIGTHQGK PYSEDYTTTE EHARVLSELL DQHVEYIEDI FGRYAREKIK 100
    ELKSGEVAIL ENLRFSAEEV KNKPIEECEK TFLVKKLSKV IDYVVNDAFA 150
    TAHRSQPSLV GFARIKPMIM GFLMEKEIEA LMRAYYSKDS PKIYVLGGAK 200
    VEDSLKVVEN VLRRERADLV LTGGLVANVF TLAKGFDLGR KNVEFMKKKG 250
    LLDYVKHAEE ILDEFYPYIR TPVDFAVDYK GERVEIDLLS ENRGLLHQYQ 300
    IMDIGKRTAE KYREILMKAR IIVANGPMGV FEREEFAIGT VEVFKAIADS 350
    PAFSVLGGGH SIASIQKYGI TGITHISTGG GAMLSFFAGE ELPVLRALQI 400
    SYEKFKEVVK 410
    Length:410
    Mass (Da):46,403
    Last modified:August 1, 1998 - v1
    Checksum:i6912EDE7BD26486E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30318.1.
    PIRiD71065.
    RefSeqiNP_143113.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA30318; BAA30318; BAA30318.
    GeneIDi1443540.
    KEGGipho:PH1218.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA30318.1 .
    PIRi D71065.
    RefSeqi NP_143113.1. NC_000961.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CUN X-ray 2.10 A/B 1-410 [» ]
    ProteinModelPortali O58965.
    SMRi O58965. Positions 1-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O58965. 1 interaction.
    MINTi MINT-1502980.
    STRINGi 70601.PH1218.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA30318 ; BAA30318 ; BAA30318 .
    GeneIDi 1443540.
    KEGGi pho:PH1218.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi TEYHANT.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci PHOR70601:GJWR-1213-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O58965.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.
    2. "Crystal structure of phosphoglycerate kinase from Pyrococcus horikoshii OT3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH SUBSTRATE.

    Entry informationi

    Entry nameiPGK_PYRHO
    AccessioniPrimary (citable) accession number: O58965
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3