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Protein

Probable aminomethyltransferase

Gene

gcvT

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:PH1146
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001226251 – 398Probable aminomethyltransferaseAdd BLAST398

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH1146.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 14Combined sources7
Beta strandi16 – 21Combined sources6
Beta strandi24 – 31Combined sources8
Helixi33 – 42Combined sources10
Beta strandi45 – 48Combined sources4
Beta strandi52 – 59Combined sources8
Helixi62 – 69Combined sources8
Beta strandi70 – 72Combined sources3
Beta strandi79 – 88Combined sources10
Beta strandi94 – 104Combined sources11
Beta strandi107 – 112Combined sources6
Turni114 – 116Combined sources3
Helixi117 – 132Combined sources16
Beta strandi140 – 143Combined sources4
Turni145 – 147Combined sources3
Beta strandi148 – 155Combined sources8
Helixi158 – 166Combined sources9
Helixi170 – 172Combined sources3
Beta strandi177 – 183Combined sources7
Beta strandi186 – 191Combined sources6
Beta strandi195 – 198Combined sources4
Beta strandi200 – 206Combined sources7
Helixi215 – 217Combined sources3
Helixi222 – 235Combined sources14
Helixi236 – 238Combined sources3
Beta strandi241 – 243Combined sources3
Helixi245 – 255Combined sources11
Turni260 – 262Combined sources3
Turni279 – 283Combined sources5
Helixi285 – 287Combined sources3
Helixi297 – 306Combined sources10
Beta strandi310 – 320Combined sources11
Beta strandi328 – 331Combined sources4
Beta strandi334 – 344Combined sources11
Turni346 – 348Combined sources3
Beta strandi350 – 358Combined sources9
Helixi359 – 361Combined sources3
Beta strandi367 – 372Combined sources6
Beta strandi375 – 382Combined sources8
Turni389 – 391Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5VX-ray1.50A/B1-398[»]
ProteinModelPortaliO58888.
SMRiO58888.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58888.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00756. Archaea.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

O58888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKRVHIFDW HKEHARKIEE FAGWEMPIWY SSIKEEHLAV RNAVGIFDVS
60 70 80 90 100
HMGEIVFRGK DALKFLQYVT TNDISKPPAI SGTYTLVLNE RGAIKDETLV
110 120 130 140 150
FNMGNNEYLM ICDSDAFEKL YAWFTYLKRT IEQFTKLDLE IELKTYDIAM
160 170 180 190 200
FAVQGPKARD LAKDLFGIDI NEMWWFQARW VELDGIKMLL SRSGYTGENG
210 220 230 240 250
FEVYIEDANP YHPDESKRGE PEKALHVWER ILEEGKKYGI KPCGLGARDT
260 270 280 290 300
LRLEAGYTLY GNETKELQLL STDIDEVTPL QANLEFAIYW DKDFIGKDAL
310 320 330 340 350
LKQKERGVGR KLVHFKMIDK GIPREGYKVY ANGEMIGEVT SGTLSPLLNV
360 370 380 390
GIGIAFVKEE YAKPGIEIEV EIRGQRKKAV TVTPPFYDPK KYGLFRET
Length:398
Mass (Da):45,799
Last modified:February 15, 2005 - v2
Checksum:iC05FE8A757346DFE
GO

Sequence cautioni

The sequence BAA30246 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30246.1. Different initiation.
PIRiD71056.
RefSeqiWP_048053320.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30246; BAA30246; BAA30246.
GeneIDi1443465.
KEGGipho:PH1146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30246.1. Different initiation.
PIRiD71056.
RefSeqiWP_048053320.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5VX-ray1.50A/B1-398[»]
ProteinModelPortaliO58888.
SMRiO58888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30246; BAA30246; BAA30246.
GeneIDi1443465.
KEGGipho:PH1146.

Phylogenomic databases

eggNOGiarCOG00756. Archaea.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.

Miscellaneous databases

EvolutionaryTraceiO58888.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT. 1 hit.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCST_PYRHO
AccessioniPrimary (citable) accession number: O58888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.