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Protein

Probable aminomethyltransferase

Gene

gcvT

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1137-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:PH1146
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Probable aminomethyltransferasePRO_0000122625Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH1146.

Structurei

Secondary structure

1
398
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 147Combined sources
Beta strandi16 – 216Combined sources
Beta strandi24 – 318Combined sources
Helixi33 – 4210Combined sources
Beta strandi45 – 484Combined sources
Beta strandi52 – 598Combined sources
Helixi62 – 698Combined sources
Beta strandi70 – 723Combined sources
Beta strandi79 – 8810Combined sources
Beta strandi94 – 10411Combined sources
Beta strandi107 – 1126Combined sources
Turni114 – 1163Combined sources
Helixi117 – 13216Combined sources
Beta strandi140 – 1434Combined sources
Turni145 – 1473Combined sources
Beta strandi148 – 1558Combined sources
Helixi158 – 1669Combined sources
Helixi170 – 1723Combined sources
Beta strandi177 – 1837Combined sources
Beta strandi186 – 1916Combined sources
Beta strandi195 – 1984Combined sources
Beta strandi200 – 2067Combined sources
Helixi215 – 2173Combined sources
Helixi222 – 23514Combined sources
Helixi236 – 2383Combined sources
Beta strandi241 – 2433Combined sources
Helixi245 – 25511Combined sources
Turni260 – 2623Combined sources
Turni279 – 2835Combined sources
Helixi285 – 2873Combined sources
Helixi297 – 30610Combined sources
Beta strandi310 – 32011Combined sources
Beta strandi328 – 3314Combined sources
Beta strandi334 – 34411Combined sources
Turni346 – 3483Combined sources
Beta strandi350 – 3589Combined sources
Helixi359 – 3613Combined sources
Beta strandi367 – 3726Combined sources
Beta strandi375 – 3828Combined sources
Turni389 – 3913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5VX-ray1.50A/B1-398[»]
ProteinModelPortaliO58888.
SMRiO58888. Positions 1-398.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58888.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00756. Archaea.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

O58888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKRVHIFDW HKEHARKIEE FAGWEMPIWY SSIKEEHLAV RNAVGIFDVS
60 70 80 90 100
HMGEIVFRGK DALKFLQYVT TNDISKPPAI SGTYTLVLNE RGAIKDETLV
110 120 130 140 150
FNMGNNEYLM ICDSDAFEKL YAWFTYLKRT IEQFTKLDLE IELKTYDIAM
160 170 180 190 200
FAVQGPKARD LAKDLFGIDI NEMWWFQARW VELDGIKMLL SRSGYTGENG
210 220 230 240 250
FEVYIEDANP YHPDESKRGE PEKALHVWER ILEEGKKYGI KPCGLGARDT
260 270 280 290 300
LRLEAGYTLY GNETKELQLL STDIDEVTPL QANLEFAIYW DKDFIGKDAL
310 320 330 340 350
LKQKERGVGR KLVHFKMIDK GIPREGYKVY ANGEMIGEVT SGTLSPLLNV
360 370 380 390
GIGIAFVKEE YAKPGIEIEV EIRGQRKKAV TVTPPFYDPK KYGLFRET
Length:398
Mass (Da):45,799
Last modified:February 15, 2005 - v2
Checksum:iC05FE8A757346DFE
GO

Sequence cautioni

The sequence BAA30246.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30246.1. Different initiation.
PIRiD71056.
RefSeqiWP_048053320.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30246; BAA30246; BAA30246.
GeneIDi1443465.
KEGGipho:PH1146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30246.1. Different initiation.
PIRiD71056.
RefSeqiWP_048053320.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5VX-ray1.50A/B1-398[»]
ProteinModelPortaliO58888.
SMRiO58888. Positions 1-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30246; BAA30246; BAA30246.
GeneIDi1443465.
KEGGipho:PH1146.

Phylogenomic databases

eggNOGiarCOG00756. Archaea.
COG0404. LUCA.
HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1137-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO58888.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiGCST_PYRHO
AccessioniPrimary (citable) accession number: O58888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.