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O58888 (GCST_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable aminomethyltransferase
EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:PH1146
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Sequence caution

The sequence BAA30246.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionaminomethyltransferase activity

Inferred from electronic annotation. Source: EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Probable aminomethyltransferase HAMAP MF_00259
PRO_0000122625

Secondary structure

1 ............................................................................ 398
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O58888 [UniParc].

Last modified February 15, 2005. Version 2.
Checksum: C05FE8A757346DFE

FASTA39845,799
        10         20         30         40         50         60 
MVKRVHIFDW HKEHARKIEE FAGWEMPIWY SSIKEEHLAV RNAVGIFDVS HMGEIVFRGK 

        70         80         90        100        110        120 
DALKFLQYVT TNDISKPPAI SGTYTLVLNE RGAIKDETLV FNMGNNEYLM ICDSDAFEKL 

       130        140        150        160        170        180 
YAWFTYLKRT IEQFTKLDLE IELKTYDIAM FAVQGPKARD LAKDLFGIDI NEMWWFQARW 

       190        200        210        220        230        240 
VELDGIKMLL SRSGYTGENG FEVYIEDANP YHPDESKRGE PEKALHVWER ILEEGKKYGI 

       250        260        270        280        290        300 
KPCGLGARDT LRLEAGYTLY GNETKELQLL STDIDEVTPL QANLEFAIYW DKDFIGKDAL 

       310        320        330        340        350        360 
LKQKERGVGR KLVHFKMIDK GIPREGYKVY ANGEMIGEVT SGTLSPLLNV GIGIAFVKEE 

       370        380        390 
YAKPGIEIEV EIRGQRKKAV TVTPPFYDPK KYGLFRET

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000001 Genomic DNA. Translation: BAA30246.1. Different initiation.
PIRD71056.
RefSeqNP_143049.1. NC_000961.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1V5VX-ray1.50A/B1-398[»]
ProteinModelPortalO58888.
SMRO58888. Positions 1-398.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000000549; EBPYRP00000000549; EBPYRG00000000549.
GeneID1443465.
GenomeReviewsGene locus PH1146 in contig BA000001_GR.
KEGGpho:PH1146.
NMPDRfig|70601.1.peg.1118.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022939.
HOGENOMHBG299834.
OMAGYPLHGQ.
PhylomeDBO58888.
ProtClustDBPRK00389.

Enzyme and pathway databases

BioCycPHOR70601:PH1146-MONOMER.

Family and domain databases

HAMAPMF_00259. GcvT.
[Tree]
InterProIPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR022903. NH2_Me_Trfase.
[Graphical view]
KOK00605.
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. GcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_PYRHO
AccessionPrimary (citable) accession number: O58888
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 15, 2005
Last modified: December 14, 2011
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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