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Protein

Xaa-Pro dipeptidase

Gene

pepQ

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position.By similarity

Catalytic activityi

Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.

Cofactori

Co2+1 PublicationNote: Binds 2 cobalt ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi212Cobalt 21
Metal bindingi223Cobalt 11
Metal bindingi223Cobalt 21
Metal bindingi287Cobalt 11
Metal bindingi316Cobalt 11
Metal bindingi330Cobalt 11
Metal bindingi330Cobalt 21

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Cobalt, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.13.9. 5244.

Protein family/group databases

MEROPSiM24.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Xaa-Pro dipeptidase (EC:3.4.13.9)
Short name:
X-Pro dipeptidase
Alternative name(s):
Imidodipeptidase
Proline dipeptidase
Short name:
Prolidase
Gene namesi
Name:pepQ
Ordered Locus Names:PH1149
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850941 – 351Xaa-Pro dipeptidaseAdd BLAST351

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi70601.PH1149.

Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Beta strandi21 – 25Combined sources5
Helixi28 – 35Combined sources8
Beta strandi44 – 48Combined sources5
Beta strandi51 – 57Combined sources7
Helixi58 – 67Combined sources10
Beta strandi72 – 77Combined sources6
Helixi78 – 85Combined sources8
Beta strandi89 – 93Combined sources5
Helixi99 – 108Combined sources10
Beta strandi113 – 116Combined sources4
Helixi118 – 125Combined sources8
Helixi130 – 153Combined sources24
Helixi160 – 173Combined sources14
Beta strandi177 – 181Combined sources5
Beta strandi184 – 187Combined sources4
Helixi188 – 192Combined sources5
Beta strandi208 – 213Combined sources6
Beta strandi215 – 217Combined sources3
Beta strandi224 – 231Combined sources8
Helixi235 – 254Combined sources20
Helixi261 – 274Combined sources14
Helixi278 – 280Combined sources3
Beta strandi285 – 288Combined sources4
Beta strandi290 – 300Combined sources11
Beta strandi312 – 315Combined sources4
Beta strandi318 – 321Combined sources4
Turni322 – 324Combined sources3
Beta strandi325 – 328Combined sources4
Beta strandi330 – 336Combined sources7
Beta strandi339 – 343Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WY2X-ray1.70A/B1-351[»]
ProteinModelPortaliO58885.
SMRiO58885.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58885.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01000. Archaea.
COG0006. LUCA.
HOGENOMiHOG000008760.
KOiK01271.
OMAiENMAIVT.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR000994. Pept_M24.
IPR001714. Pept_M24_MAP.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIMNEKVKK IIEFMDKNSI DAVLIAKNPN VYYISGASPL AGGYILITGE
60 70 80 90 100
SATLYVPELE YEMAKEESNI PVEKFKKMDE FYKALEGIKS LGIESSLPYG
110 120 130 140 150
FIEELKKKAN IKEFKKVDDV IRDMRIIKSE KEIKIIEKAC EIADKAVMAA
160 170 180 190 200
IEEITEGKKE REVAAKVEYL MKMNGAEKPA FDTIIASGYR SALPHGVASD
210 220 230 240 250
KRIERGDLVV IDLGALYQHY NSDITRTIVV GSPNEKQKEI YEIVLEAQKK
260 270 280 290 300
AVESAKPGIT AKELDSIARN IIAEYGYGEY FNHSLGHGVG LEVHEWPRVS
310 320 330 340 350
QYDETVLREG MVITIEPGIY IPKIGGVRIE DTILITKNGS KRLTKTEREL

I
Length:351
Mass (Da):39,401
Last modified:August 1, 1998 - v1
Checksum:i38CB76FFFB766A7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30249.1.
PIRiG71056.

Genome annotation databases

EnsemblBacteriaiBAA30249; BAA30249; BAA30249.
KEGGipho:PH1149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30249.1.
PIRiG71056.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WY2X-ray1.70A/B1-351[»]
ProteinModelPortaliO58885.
SMRiO58885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1149.

Protein family/group databases

MEROPSiM24.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30249; BAA30249; BAA30249.
KEGGipho:PH1149.

Phylogenomic databases

eggNOGiarCOG01000. Archaea.
COG0006. LUCA.
HOGENOMiHOG000008760.
KOiK01271.
OMAiENMAIVT.

Enzyme and pathway databases

BRENDAi3.4.13.9. 5244.

Miscellaneous databases

EvolutionaryTraceiO58885.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR000994. Pept_M24.
IPR001714. Pept_M24_MAP.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPQ_PYRHO
AccessioniPrimary (citable) accession number: O58885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.