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Protein

Xaa-Pro dipeptidase

Gene

pepQ

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position.By similarity

Catalytic activityi

Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.

Cofactori

Co2+1 PublicationNote: Binds 2 cobalt ions per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi212 – 2121Cobalt 2
Metal bindingi223 – 2231Cobalt 1
Metal bindingi223 – 2231Cobalt 2
Metal bindingi287 – 2871Cobalt 1
Metal bindingi316 – 3161Cobalt 1
Metal bindingi330 – 3301Cobalt 1
Metal bindingi330 – 3301Cobalt 2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Cobalt, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1140-MONOMER.
BRENDAi3.4.13.9. 5244.

Protein family/group databases

MEROPSiM24.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Xaa-Pro dipeptidase (EC:3.4.13.9)
Short name:
X-Pro dipeptidase
Alternative name(s):
Imidodipeptidase
Proline dipeptidase
Short name:
Prolidase
Gene namesi
Name:pepQ
Ordered Locus Names:PH1149
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Xaa-Pro dipeptidasePRO_0000185094Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi70601.PH1149.

Structurei

Secondary structure

1
351
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712Combined sources
Beta strandi21 – 255Combined sources
Helixi28 – 358Combined sources
Beta strandi44 – 485Combined sources
Beta strandi51 – 577Combined sources
Helixi58 – 6710Combined sources
Beta strandi72 – 776Combined sources
Helixi78 – 858Combined sources
Beta strandi89 – 935Combined sources
Helixi99 – 10810Combined sources
Beta strandi113 – 1164Combined sources
Helixi118 – 1258Combined sources
Helixi130 – 15324Combined sources
Helixi160 – 17314Combined sources
Beta strandi177 – 1815Combined sources
Beta strandi184 – 1874Combined sources
Helixi188 – 1925Combined sources
Beta strandi208 – 2136Combined sources
Beta strandi215 – 2173Combined sources
Beta strandi224 – 2318Combined sources
Helixi235 – 25420Combined sources
Helixi261 – 27414Combined sources
Helixi278 – 2803Combined sources
Beta strandi285 – 2884Combined sources
Beta strandi290 – 30011Combined sources
Beta strandi312 – 3154Combined sources
Beta strandi318 – 3214Combined sources
Turni322 – 3243Combined sources
Beta strandi325 – 3284Combined sources
Beta strandi330 – 3367Combined sources
Beta strandi339 – 3435Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WY2X-ray1.70A/B1-351[»]
ProteinModelPortaliO58885.
SMRiO58885. Positions 1-351.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58885.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01000. Archaea.
COG0006. LUCA.
HOGENOMiHOG000008760.
KOiK01271.
OMAiENMAIVT.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIMNEKVKK IIEFMDKNSI DAVLIAKNPN VYYISGASPL AGGYILITGE
60 70 80 90 100
SATLYVPELE YEMAKEESNI PVEKFKKMDE FYKALEGIKS LGIESSLPYG
110 120 130 140 150
FIEELKKKAN IKEFKKVDDV IRDMRIIKSE KEIKIIEKAC EIADKAVMAA
160 170 180 190 200
IEEITEGKKE REVAAKVEYL MKMNGAEKPA FDTIIASGYR SALPHGVASD
210 220 230 240 250
KRIERGDLVV IDLGALYQHY NSDITRTIVV GSPNEKQKEI YEIVLEAQKK
260 270 280 290 300
AVESAKPGIT AKELDSIARN IIAEYGYGEY FNHSLGHGVG LEVHEWPRVS
310 320 330 340 350
QYDETVLREG MVITIEPGIY IPKIGGVRIE DTILITKNGS KRLTKTEREL

I
Length:351
Mass (Da):39,401
Last modified:August 1, 1998 - v1
Checksum:i38CB76FFFB766A7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30249.1.
PIRiG71056.

Genome annotation databases

EnsemblBacteriaiBAA30249; BAA30249; BAA30249.
KEGGipho:PH1149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30249.1.
PIRiG71056.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WY2X-ray1.70A/B1-351[»]
ProteinModelPortaliO58885.
SMRiO58885. Positions 1-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1149.

Protein family/group databases

MEROPSiM24.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30249; BAA30249; BAA30249.
KEGGipho:PH1149.

Phylogenomic databases

eggNOGiarCOG01000. Archaea.
COG0006. LUCA.
HOGENOMiHOG000008760.
KOiK01271.
OMAiENMAIVT.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1140-MONOMER.
BRENDAi3.4.13.9. 5244.

Miscellaneous databases

EvolutionaryTraceiO58885.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPQ_PYRHO
AccessioniPrimary (citable) accession number: O58885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.