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Protein

Ribonuclease Z

Gene

rnz

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc 1; catalyticUniRule annotation1
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Active sitei65Proton acceptorUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi138Zinc 1; catalyticUniRule annotation1
Metal bindingi208Zinc 1; catalyticUniRule annotation1
Metal bindingi208Zinc 2; catalyticUniRule annotation1
Metal bindingi264Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1113-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:PH1151
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559341 – 307Ribonuclease ZAdd BLAST307

Proteomic databases

PRIDEiO58883

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH1151

Structurei

3D structure databases

ProteinModelPortaliO58883
SMRiO58883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501 Archaea
COG1234 LUCA
HOGENOMiHOG000272419
KOiK00784
OMAiGTQRQMM
OrthoDBiPOG093Z04VY

Family and domain databases

CDDicd07717 RNaseZ_ZiPD-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01818 RNase_Z_BN, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR013471 RNase_Z/BN
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
PF12706 Lactamase_B_2, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR02651 RNase_Z, 1 hit

Sequencei

Sequence statusi: Complete.

O58883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVIFLGTG GIKPTPERNV PSIAIKIGGE IILFDVGEGT LRQMEIARIS
60 70 80 90 100
PMKIKRVFIT HFHGDHYLGL PALIQTMSLW KRKDPLHIYG PEGSSTFLQN
110 120 130 140 150
LLNSGYFAPS FDILVHEISG KSRLKFKEYE VWAFEVSHGV PALGYVFKEK
160 170 180 190 200
DKRGNFNLKK IKELGLEPGP WMKELERQKI IEINGKIVRL LEVTGPKKRG
210 220 230 240 250
AKVVYSGDTE PCDEVIEFSR RGTLLIHEAT YVNEEDRKDS YHTTIEEACE
260 270 280 290 300
IWKKSKARKL VLFHRSPRYS FKEYKEKALS ICPQAIIPRD FDRIAIEGAG

DVLFKIR
Length:307
Mass (Da):35,131
Last modified:August 1, 1998 - v1
Checksum:i602F289A2739BD04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30251.1
PIRiA71057
RefSeqiWP_010885235.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30251; BAA30251; BAA30251
GeneIDi1443470
KEGGipho:PH1151

Similar proteinsi

Entry informationi

Entry nameiRNZ_PYRHO
AccessioniPrimary (citable) accession number: O58883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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