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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

PH1124

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28MagnesiumUniRule annotation1
Metal bindingi57MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1112-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:PH1124
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001387411 – 254Geranylgeranylglyceryl phosphate synthaseAdd BLAST254

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1124.

Structurei

3D structure databases

ProteinModelPortaliO58851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 182Glycerol-1-phosphate bindingUniRule annotation7
Regioni207 – 208Glycerol-1-phosphate bindingUniRule annotation2
Regioni229 – 230Glycerol-1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Family and domain databases

CDDicd02812. PcrB_like. 1 hit.
Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.

Sequencei

Sequence statusi: Complete.

O58851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELRIGKVE KYIHEKLEKK KLHFVLIDPD DTSPEVAGKL ARVCEELGVD
60 70 80 90 100
AIMVGGSTGA EGEVLDNVVR SIKDNSSLPV ILFPGSHGGI SRYADAIFFM
110 120 130 140 150
SLLNSRNPFF ITGAQALGAF TVKKFGIEPI PMAYIVVEPG ETVGWVGDAR
160 170 180 190 200
PIPRHKPKLA AAYALAGQYL GMRLVYLEAG SGAPEPVPEE MVRVVKSVID
210 220 230 240 250
VPLIVGGGIK SGEQAKKLIK SGADIIVTGT AIEKAKSLEE ARKRLEAIRN

GVFV
Length:254
Mass (Da):27,219
Last modified:August 1, 1998 - v1
Checksum:i893138F62E3A096E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30223.1.
PIRiE71053.
RefSeqiWP_010885207.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30223; BAA30223; BAA30223.
GeneIDi1443442.
KEGGipho:PH1124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30223.1.
PIRiE71053.
RefSeqiWP_010885207.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO58851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30223; BAA30223; BAA30223.
GeneIDi1443442.
KEGGipho:PH1124.

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciPHOR70601:GJWR-1112-MONOMER.

Family and domain databases

CDDicd02812. PcrB_like. 1 hit.
Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGGPS_PYRHO
AccessioniPrimary (citable) accession number: O58851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.