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Protein

Homoserine kinase

Gene

thrB

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (PH0858)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homoserine kinase (thrB)
  5. Threonine synthase (PH0857)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 9311ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1079-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:PH1087
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Homoserine kinasePRO_0000156647Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1087.

Structurei

3D structure databases

ProteinModelPortaliO58814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01027. Archaea.
COG0083. LUCA.
HOGENOMiHOG000247197.
KOiK00872.
OMAiVVEPCRA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.

Sequencei

Sequence statusi: Complete.

O58814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKVRAPAT IANFGPGFDV FGMAIDKPFD EVVVEEFNEF EIISSGYPVP
60 70 80 90 100
NGEDNIALFS AKTLFKMLNI EGGLRIKLKK GIRPKSGLGS SGASAVAGAL
110 120 130 140 150
GAAKLLGVSN DELILKAAMK GEEKASGEPH PDNVVPSYYG GFTVIESKSP
160 170 180 190 200
LRVHFVDAKL RGVVVLPEVE IPTAKARKIL PSMVPLKDAV KNIAMASSLI
210 220 230 240 250
LALKEGDLET IGRLLDDNLA LPYRKKLMPW FDEIRRVALE TGAYGITVSG
260 270 280 290
SGPALFAIGE NLKDIGKTIV EKFEELGIKA EYWVTKTGRG AKT
Length:293
Mass (Da):31,485
Last modified:June 1, 2001 - v2
Checksum:i33148C4B26232F63
GO

Sequence cautioni

The sequence BAA30186 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30186.1. Different initiation.
PIRiD71103.

Genome annotation databases

EnsemblBacteriaiBAA30186; BAA30186; BAA30186.
KEGGipho:PH1087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30186.1. Different initiation.
PIRiD71103.

3D structure databases

ProteinModelPortaliO58814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30186; BAA30186; BAA30186.
KEGGipho:PH1087.

Phylogenomic databases

eggNOGiarCOG01027. Archaea.
COG0083. LUCA.
HOGENOMiHOG000247197.
KOiK00872.
OMAiVVEPCRA.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.
BioCyciPHOR70601:GJWR-1079-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKHSE_PYRHO
AccessioniPrimary (citable) accession number: O58814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.