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Protein

Homoserine kinase

Gene

thrB

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (PH0858)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homoserine kinase (thrB)
  5. Threonine synthase (PH0857)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 93ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:PH1087
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566471 – 293Homoserine kinaseAdd BLAST293

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1087

Structurei

3D structure databases

ProteinModelPortaliO58814
SMRiO58814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01027 Archaea
COG0083 LUCA
HOGENOMiHOG000247197
KOiK00872
OMAiPDNVAPC
OrthoDBiPOG093Z0AGJ

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00384 Homoser_kinase, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR000870 Homoserine_kinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000676 Homoser_kin, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00191 thrB, 1 hit

Sequencei

Sequence statusi: Complete.

O58814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKVRAPAT IANFGPGFDV FGMAIDKPFD EVVVEEFNEF EIISSGYPVP
60 70 80 90 100
NGEDNIALFS AKTLFKMLNI EGGLRIKLKK GIRPKSGLGS SGASAVAGAL
110 120 130 140 150
GAAKLLGVSN DELILKAAMK GEEKASGEPH PDNVVPSYYG GFTVIESKSP
160 170 180 190 200
LRVHFVDAKL RGVVVLPEVE IPTAKARKIL PSMVPLKDAV KNIAMASSLI
210 220 230 240 250
LALKEGDLET IGRLLDDNLA LPYRKKLMPW FDEIRRVALE TGAYGITVSG
260 270 280 290
SGPALFAIGE NLKDIGKTIV EKFEELGIKA EYWVTKTGRG AKT
Length:293
Mass (Da):31,485
Last modified:June 1, 2001 - v2
Checksum:i33148C4B26232F63
GO

Sequence cautioni

The sequence BAA30186 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30186.1 Different initiation.
PIRiD71103

Genome annotation databases

EnsemblBacteriaiBAA30186; BAA30186; BAA30186
KEGGipho:PH1087

Similar proteinsi

Entry informationi

Entry nameiKHSE_PYRHO
AccessioniPrimary (citable) accession number: O58814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health