ID   AOR_PYRHO               Reviewed;         607 AA.
AC   O58778;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Tungsten-containing aldehyde ferredoxin oxidoreductase;
DE            EC=1.2.7.5;
GN   Name=aor; OrderedLocusNames=PH1019;
OS   Pyrococcus horikoshii.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=53953;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT3;
RX   MEDLINE=98344137; PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y.,
RA   Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y.,
RA   Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K.,
RA   Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + H(2)O + 2 oxidized ferredoxin =
CC       an acid + 2 H(+) + 2 reduced ferredoxin.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).
CC   -!- COFACTOR: Binds 1 tungstopterin cofactor per subunit (By
CC       similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the AOR/FOR family.
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DR   EMBL; BA000001; BAA30116.1; -; Genomic_DNA.
DR   PIR; F71094; F71094.
DR   RefSeq; NP_142931.1; -.
DR   HSSP; Q51739; 1AOR.
DR   SMR; O58778; 1-606.
DR   GeneID; 1443341; -.
DR   GenomeReviews; BA000001_GR; PH1019.
DR   KEGG; pho:PH1019; -.
DR   NMPDR; fig|70601.1.peg.994; -.
DR   HOGENOM; O58778; -.
DR   OMA; O58778; CTIACGR.
DR   BRENDA; 1.2.7.5; 74679.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   Gene3D; G3DSA:1.10.599.10; Oxred_Ald_Fedxn_3; 1.
DR   Gene3D; G3DSA:3.60.9.10; Oxred_Ald_Fedxn_N; 1.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Oxidoreductase; Tungsten.
FT   CHAIN         1    607       Tungsten-containing aldehyde ferredoxin
FT                                oxidoreductase.
FT                                /FTId=PRO_0000064607.
SQ   SEQUENCE   607 AA;  67537 MW;  978039536AA58FBE CRC64;
     MFGYWGKILR VNLSDGTIKE ETFNEEFAKK WLGTRGFGIY FLLKEMDPKI DPFSPENKLI
     FATGPLTGTS APTGGRYMVI TKSPLTGYIA MANSGGYFGA ELKFAGWDAI IVEGKADHPV
     YIYINDENVE IRDASKVWGK LVSETERMLK EEVGDKHVQI ASIGPAGENK VRFAAVMNNG
     HRAAGRGGVG AVMGSKNLKA IVVRGHKRVE VADKGKFMEV IREKIEKLRK DPVAGGGLPK
     YGTAVLVNII NEHGLYPTRN FQTGVFKYAY EQSGEAMAAK YLVRNKPCFA CPIGCGRVNY
     LPSIGETEGP EYESTWALGA NLGINDLASI IEANHFADEY GMDTISLGGT LATAMELYER
     GLIKQEDIGG ENEPPFRFGN TEVLHYWIHK IAKREGFGDI LAEGGYRLAE KFNGLEYFMG
     VKKQELPAYD PRGAEGHGLG YATNNRGGCH IKQYMISPEI LGYPYKMDPH DISDEKVKMV
     ILFQDLTAVI DAAGLCIFTT FGLGADDYTD MLNAALGWDF STDDYLKIGE RIWNAERLFN
     LKAGLDPLKE DTLPKRFLEE PMPEGPNKGH VVRLKEMLPR YYKLRGWTED GRIPEEKLKE
     LGLEEFM
//