Reviewed, UniProtKB/Swiss-Prot O58778 (AOR_PYRHO)

Names and originHide

Protein names

Recommended name:
Tungsten-containing aldehyde ferredoxin oxidoreductase
EC=1.2.7.5

Gene names

Name:	aor
Ordered Locus Names:	PH1019

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributesHide

Sequence length	607 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Catalytic activity	An aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin.
Cofactor	Binds 1 4Fe-4S cluster per subunit By similarity. Binds 1 tungstopterin cofactor per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the AOR/FOR family.

OntologiesHide

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding Tungsten
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW aldehyde ferredoxin oxidoreductase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 607	607	Tungsten-containing aldehyde ferredoxin oxidoreductase		PRO_0000064607

SequencesHide

	Sequence		Length	Mass (Da)
	O58778-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 978039536AA58FBE	FASTA	607	67,537
	10 20 30 40 50 60 MFGYWGKILR VNLSDGTIKE ETFNEEFAKK WLGTRGFGIY FLLKEMDPKI DPFSPENKLI 70 80 90 100 110 120 FATGPLTGTS APTGGRYMVI TKSPLTGYIA MANSGGYFGA ELKFAGWDAI IVEGKADHPV 130 140 150 160 170 180 YIYINDENVE IRDASKVWGK LVSETERMLK EEVGDKHVQI ASIGPAGENK VRFAAVMNNG 190 200 210 220 230 240 HRAAGRGGVG AVMGSKNLKA IVVRGHKRVE VADKGKFMEV IREKIEKLRK DPVAGGGLPK 250 260 270 280 290 300 YGTAVLVNII NEHGLYPTRN FQTGVFKYAY EQSGEAMAAK YLVRNKPCFA CPIGCGRVNY 310 320 330 340 350 360 LPSIGETEGP EYESTWALGA NLGINDLASI IEANHFADEY GMDTISLGGT LATAMELYER 370 380 390 400 410 420 GLIKQEDIGG ENEPPFRFGN TEVLHYWIHK IAKREGFGDI LAEGGYRLAE KFNGLEYFMG 430 440 450 460 470 480 VKKQELPAYD PRGAEGHGLG YATNNRGGCH IKQYMISPEI LGYPYKMDPH DISDEKVKMV 490 500 510 520 530 540 ILFQDLTAVI DAAGLCIFTT FGLGADDYTD MLNAALGWDF STDDYLKIGE RIWNAERLFN 550 560 570 580 590 600 LKAGLDPLKE DTLPKRFLEE PMPEGPNKGH VVRLKEMLPR YYKLRGWTED GRIPEEKLKE LGLEEFM

ReferencesHide

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA30116.1.
PIR	F71094.
RefSeq	NP_142931.1.
3D structure databases
SMR	O58778. Positions 1-606.
ModBase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000002042; EBPYRP00000002042; EBPYRG00000002042.
GeneID	1443341.
GenomeReviews	Gene locus PH1019 in contig BA000001_GR.
KEGG	pho:PH1019.
NMPDR	fig|70601.1.peg.994.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG496827.
OMA	FGCTIAC.
ProtClustDB	CLSK253319.
Enzyme and pathway databases
BioCyc	PHOR70601:PH1019-MONOMER.
BRENDA	1.2.7.5. 74679.
Family and domain databases
InterPro	IPR013985. Ald_Fedxn_OxRdtase_3. IPR013983. Ald_Fedxn_OxRdtase_N. IPR001203. OxRdtase_Ald_Fedxn_C. [Graphical view]
Gene3D	G3DSA:1.10.599.10. Oxred_Ald_Fedxn_3. 1 hit. G3DSA:3.60.9.10. Oxred_Ald_Fedxn_N. 1 hit.
Pfam	PF01314. AFOR_C. 1 hit. PF02730. AFOR_N. 1 hit. [Graphical view]
SMART	SM00790. AFOR_N. 1 hit. [Graphical view]
SUPFAM	SSF48310. Oxred_Ald_Fedxn_C. 1 hit. SSF56228. Oxred_Ald_Fedxn_N. 1 hit.
ProtoNet	Search...

Entry informationHide

Entry name

AOR_PYRHO

Accession

Primary (citable) accession number: O58778

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	July 13, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)