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Protein

Trehalose synthase

Gene

treT

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes trehalose from ADP-, UDP- or GDP-glucose and glucose.1 Publication

Catalytic activityi

NDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + NDP.1 Publication

Cofactori

Mg2+By similarity

pH dependencei

Optimum pH is 5.5. Stable from pH 5 to pH 8.1 Publication

Temperature dependencei

Not thermostable. Approximately 25% of maximum activity remains after 1 hour incubation at 55 degrees Celsius.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1029-MONOMER.
BRENDAi2.4.1.245. 5244.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose synthaseBy similarity (EC:2.4.1.245)
Alternative name(s):
Trehalose-synthesizing glycosyltransferase1 Publication
Gene namesi
Name:treTBy similarity
Ordered Locus Names:PH1035
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Trehalose synthasePRO_0000405300Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1035.

Structurei

Secondary structure

1
415
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Helixi15 – 184Combined sources
Helixi19 – 3517Combined sources
Turni36 – 394Combined sources
Beta strandi41 – 477Combined sources
Beta strandi49 – 524Combined sources
Helixi54 – 6714Combined sources
Beta strandi71 – 766Combined sources
Helixi81 – 9414Combined sources
Helixi104 – 11916Combined sources
Helixi123 – 1253Combined sources
Beta strandi126 – 1349Combined sources
Helixi137 – 1426Combined sources
Beta strandi149 – 1524Combined sources
Helixi162 – 17211Combined sources
Beta strandi175 – 1828Combined sources
Helixi183 – 1853Combined sources
Turni192 – 1943Combined sources
Beta strandi195 – 1973Combined sources
Turni207 – 2093Combined sources
Helixi214 – 22310Combined sources
Beta strandi232 – 2365Combined sources
Helixi245 – 25814Combined sources
Beta strandi263 – 2686Combined sources
Helixi275 – 28814Combined sources
Beta strandi294 – 2985Combined sources
Helixi299 – 3013Combined sources
Helixi305 – 31410Combined sources
Beta strandi316 – 3205Combined sources
Helixi329 – 3368Combined sources
Beta strandi341 – 3455Combined sources
Helixi347 – 3526Combined sources
Turni355 – 3573Combined sources
Beta strandi358 – 3647Combined sources
Helixi365 – 37713Combined sources
Helixi379 – 39618Combined sources
Helixi399 – 41113Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X6QX-ray2.20A/B2-415[»]
2X6RX-ray2.20A/B2-415[»]
2XA1X-ray2.47A/B2-415[»]
2XA2X-ray2.50A/B2-415[»]
2XA9X-ray2.50A/B2-415[»]
2XMPX-ray2.50A/B2-415[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58762.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01407. Archaea.
COG0438. LUCA.
HOGENOMiHOG000227006.
KOiK13057.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYEVKEFSS GKRKLEDYKS IIGEEEVSKI QEKAEKLKGR SFVHVNSTSF
60 70 80 90 100
GGGVAEILHS LVPLLRSIGI EARWFVIEGP TEFFNVTKTF HNALQGNESL
110 120 130 140 150
KLTEEMKELY LNVNRENSKF IDLSSFDYVL VHDPQPAALI EFYEKKSPWL
160 170 180 190 200
WRCHIDLSSP NREFWEFLRR FVEKYDRYIF HLPEYVQPEL DRNKAVIMPP
210 220 230 240 250
SIDPLSEKNV ELKQTEILRI LERFDVDPEK PIITQVSRFD PWKGIFDVIE
260 270 280 290 300
IYRKVKEKIP GVQLLLVGVM AHDDPEGWIY FEKTLRKIGE DYDVKVLTNL
310 320 330 340 350
IGVHAREVNA FQRASDVILQ MSIREGFGLT VTEAMWKGKP VIGRAVGGIK
360 370 380 390 400
FQIVDGETGF LVRDANEAVE KVLYLLKHPE VSKEMGAKAK ERVRKNFIIT
410
KHMERYLDIL NSLGG
Length:415
Mass (Da):48,069
Last modified:March 8, 2011 - v2
Checksum:i5ED5B806043842FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30133.1.
PIRiG71096.

Genome annotation databases

EnsemblBacteriaiBAA30133; BAA30133; BAA30133.
KEGGipho:PH1035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30133.1.
PIRiG71096.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X6QX-ray2.20A/B2-415[»]
2X6RX-ray2.20A/B2-415[»]
2XA1X-ray2.47A/B2-415[»]
2XA2X-ray2.50A/B2-415[»]
2XA9X-ray2.50A/B2-415[»]
2XMPX-ray2.50A/B2-415[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1035.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

DNASUi1443358.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30133; BAA30133; BAA30133.
KEGGipho:PH1035.

Phylogenomic databases

eggNOGiarCOG01407. Archaea.
COG0438. LUCA.
HOGENOMiHOG000227006.
KOiK13057.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-1029-MONOMER.
BRENDAi2.4.1.245. 5244.

Miscellaneous databases

EvolutionaryTraceiO58762.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRET_PYRHO
AccessioniPrimary (citable) accession number: O58762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 11, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.