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O58727

- O58727_PYRHO

UniProt

O58727 - O58727_PYRHO

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Protein
Submitted name:

180aa long hypothetical pyrazinamidase/nicotinamidase

Gene

PH0999

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Proton donor/acceptorImported
Metal bindingi52 – 521ZincImported
Metal bindingi54 – 541Zinc; via tele nitrogenImported
Metal bindingi71 – 711Zinc; via tele nitrogenImported
Sitei94 – 941Important for catalytic activityImported
Binding sitei129 – 1291Substrate; via amide nitrogenImported
Active sitei133 – 1331NucleophileImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, ZincImported

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-991-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
180aa long hypothetical pyrazinamidase/nicotinamidaseImported
Gene namesi
Ordered Locus Names:PH0999Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0999.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ILWX-ray2.05A1-180[»]
1IM5X-ray1.65A1-180[»]
ProteinModelPortaliO58727.
SMRiO58727. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58727.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1335.
HOGENOMiHOG000078666.
KOiK08281.
OMAiERSEACI.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.

Sequencei

Sequence statusi: Complete.

O58727 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEEALIVVD MQRDFMPGGA LPVPEGDKII PKVNEYIRKF KEKGALIVAT
60 70 80 90 100
RDWHPENHIS FRERGGPWPR HCVQNTPGAE FVVDLPEDAV IISKATEPDK
110 120 130 140 150
EAYSGFEGTD LAKILRGNGV KRVYICGVAT EYCVRATALD ALKHGFEVYL
160 170 180
LRDAVKGIKP EDEERALEEM KSRGIKIVQF
Length:180
Mass (Da):20,192
Last modified:August 1, 1998 - v1
Checksum:i7FFEE8E90C0EE89C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA30096.1.
PIRiB71092.
RefSeqiNP_142913.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30096; BAA30096; BAA30096.
GeneIDi1443321.
KEGGipho:PH0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA30096.1 .
PIRi B71092.
RefSeqi NP_142913.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ILW X-ray 2.05 A 1-180 [» ]
1IM5 X-ray 1.65 A 1-180 [» ]
ProteinModelPortali O58727.
SMRi O58727. Positions 2-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA30096 ; BAA30096 ; BAA30096 .
GeneIDi 1443321.
KEGGi pho:PH0999.

Phylogenomic databases

eggNOGi COG1335.
HOGENOMi HOG000078666.
KOi K08281.
OMAi ERSEACI.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-991-MONOMER.

Miscellaneous databases

EvolutionaryTracei O58727.

Family and domain databases

Gene3Di 3.40.50.850. 1 hit.
InterProi IPR000868. Isochorismatase-like.
[Graphical view ]
Pfami PF00857. Isochorismatase. 1 hit.
[Graphical view ]
SUPFAMi SSF52499. SSF52499. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3Imported.
  2. "Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii."
    Du X., Wang W., Kim R., Yakota H., Nguyen H., Kim S.H.
    Biochemistry 40:14166-14172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH ZINC, ACTIVE SITE.

Entry informationi

Entry nameiO58727_PYRHO
AccessioniPrimary (citable) accession number: O58727
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3