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O58727

- O58727_PYRHO

UniProt

O58727 - O58727_PYRHO

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Protein
Submitted name:

180aa long hypothetical pyrazinamidase/nicotinamidase

Gene
PH0999
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Proton donor/acceptorImported
Metal bindingi52 – 521ZincImported
Metal bindingi54 – 541Zinc; via tele nitrogenImported
Metal bindingi71 – 711Zinc; via tele nitrogenImported
Sitei94 – 941Important for catalytic activityImported
Binding sitei129 – 1291Substrate; via amide nitrogenImported
Active sitei133 – 1331NucleophileImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, ZincImported

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-991-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
180aa long hypothetical pyrazinamidase/nicotinamidaseImported
Gene namesi
Ordered Locus Names:PH0999Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0999.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ILWX-ray2.05A1-180[»]
1IM5X-ray1.65A1-180[»]
ProteinModelPortaliO58727.
SMRiO58727. Positions 2-180.

Miscellaneous databases

EvolutionaryTraceiO58727.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1335.
HOGENOMiHOG000078666.
KOiK08281.
OMAiERSEACI.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.

Sequencei

Sequence statusi: Complete.

O58727-1 [UniParc]FASTAAdd to Basket

« Hide

MPEEALIVVD MQRDFMPGGA LPVPEGDKII PKVNEYIRKF KEKGALIVAT    50
RDWHPENHIS FRERGGPWPR HCVQNTPGAE FVVDLPEDAV IISKATEPDK 100
EAYSGFEGTD LAKILRGNGV KRVYICGVAT EYCVRATALD ALKHGFEVYL 150
LRDAVKGIKP EDEERALEEM KSRGIKIVQF 180
Length:180
Mass (Da):20,192
Last modified:August 1, 1998 - v1
Checksum:i7FFEE8E90C0EE89C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA30096.1.
PIRiB71092.
RefSeqiNP_142913.1. NC_000961.1.
WP_010885086.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30096; BAA30096; BAA30096.
GeneIDi1443321.
KEGGipho:PH0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA30096.1 .
PIRi B71092.
RefSeqi NP_142913.1. NC_000961.1.
WP_010885086.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ILW X-ray 2.05 A 1-180 [» ]
1IM5 X-ray 1.65 A 1-180 [» ]
ProteinModelPortali O58727.
SMRi O58727. Positions 2-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA30096 ; BAA30096 ; BAA30096 .
GeneIDi 1443321.
KEGGi pho:PH0999.

Phylogenomic databases

eggNOGi COG1335.
HOGENOMi HOG000078666.
KOi K08281.
OMAi ERSEACI.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-991-MONOMER.

Miscellaneous databases

EvolutionaryTracei O58727.

Family and domain databases

Gene3Di 3.40.50.850. 1 hit.
InterProi IPR000868. Isochorismatase-like.
[Graphical view ]
Pfami PF00857. Isochorismatase. 1 hit.
[Graphical view ]
SUPFAMi SSF52499. SSF52499. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.
  2. "Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii."
    Du X., Wang W., Kim R., Yakota H., Nguyen H., Kim S.H.
    Biochemistry 40:14166-14172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH ZINC, ACTIVE SITE.

Entry informationi

Entry nameiO58727_PYRHO
AccessioniPrimary (citable) accession number: O58727
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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