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Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit alpha
Alternative name(s):
aIF2-alpha
eIF-2-alpha
Gene namesi
Name:eif2a
Ordered Locus Names:PH0961
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374001 – 275Translation initiation factor 2 subunit alphaAdd BLAST275

Proteomic databases

PRIDEiO58655.

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi70601.PH0961.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 23Combined sources10
Beta strandi26 – 31Combined sources6
Beta strandi38 – 42Combined sources5
Helixi43 – 45Combined sources3
Helixi54 – 56Combined sources3
Beta strandi63 – 72Combined sources10
Turni73 – 76Combined sources4
Beta strandi77 – 82Combined sources6
Helixi87 – 114Combined sources28
Helixi118 – 124Combined sources7
Helixi126 – 133Combined sources8
Helixi136 – 146Combined sources11
Helixi148 – 151Combined sources4
Helixi157 – 159Combined sources3
Helixi160 – 170Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AEVX-ray2.80A1-275[»]
ProteinModelPortaliO58655.
SMRiO58655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58655.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83S1 motifAdd BLAST72

Sequence similaritiesi

Belongs to the eIF-2-alpha family.Curated
Contains 1 S1 motif domain.Curated

Phylogenomic databases

eggNOGiarCOG04107. Archaea.
COG1093. LUCA.
HOGENOMiHOG000224965.
KOiK03237.
OMAiSIQHTIE.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
3.30.70.1130. 1 hit.
HAMAPiMF_00231. eIF_2_alpha. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PANTHERiPTHR10602. PTHR10602. 1 hit.
PfamiPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKAREYPE EGEFVVATVK RIHNYGAFLE LDEYPGKEAF MHISEVASTW
60 70 80 90 100
VRNIRDYLKE GQKVVAKVIR VDPRKGHIDL SLRRVTQQQR KAKLQEFKRA
110 120 130 140 150
QKAENLLRLA AEKLGKDFEA AWREVWVPLE EEWGEVYAAF EDAAKDGIEV
160 170 180 190 200
LKGHVPDEWL PVLKEIVENY VEVPTVTIDA EFEITVPKPN GVEIIKEALI
210 220 230 240 250
RARDRANKEK DIEVKFTYQG APRYRIDITA PDYYKAEEVL EDIAEEILRV
260 270
IKQAGGEATL LRKEKRIRKV KKRKK
Length:275
Mass (Da):31,980
Last modified:August 1, 1998 - v1
Checksum:i6AAAD15F10FFB436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30058.1.
PIRiD71087.
RefSeqiWP_010885052.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA30058; BAA30058; BAA30058.
GeneIDi1443287.
KEGGipho:PH0961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30058.1.
PIRiD71087.
RefSeqiWP_010885052.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AEVX-ray2.80A1-275[»]
ProteinModelPortaliO58655.
SMRiO58655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0961.

Proteomic databases

PRIDEiO58655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30058; BAA30058; BAA30058.
GeneIDi1443287.
KEGGipho:PH0961.

Phylogenomic databases

eggNOGiarCOG04107. Archaea.
COG1093. LUCA.
HOGENOMiHOG000224965.
KOiK03237.
OMAiSIQHTIE.

Miscellaneous databases

EvolutionaryTraceiO58655.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
3.30.70.1130. 1 hit.
HAMAPiMF_00231. eIF_2_alpha. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PANTHERiPTHR10602. PTHR10602. 1 hit.
PfamiPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2A_PYRHO
AccessioniPrimary (citable) accession number: O58655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.