O58588 (O58588_PYRHO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartokinase RuleBase RU003448
EC=2.7.2.4 RuleBase RU003448

Gene names

Ordered Locus Names:

PH0858

Organism

Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]

Taxonomic identifier

70601 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate. RuleBase RU003448
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 1/4. RuleBase RU004249 Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. RuleBase RU004249 Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. RuleBase RU004249
Sequence similarities	Belongs to the aspartokinase family. RuleBase RU003448

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004249
Molecular function	Kinase RuleBase RU003448 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O58588 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 456F3A8C91B79682	FASTA	359	39,911
	10 20 30 40 50 60 MVEKPVVIKF GGTSVRYAFE EALELVAKLH ENMKIIVVVS ALAGVTDCLL RLAKGDKSAL 70 80 90 100 110 120 LEIDEIHEEL SQELNVQLEH LIHQLKKTIN SKSSFPSEKA FIDEIASFGE RFSAKLFSEG 130 140 150 160 170 180 LKILGITARP VDSKDVLFVK GEFGNAEVEF KKSAQGVDVL YRMLRRGIVP VVTGYYGNLN 190 200 210 220 230 240 GFRATFGRGG SDYSATSIAS LVNAKAVLIM SDVEGIYTAD PKLVPPARLI HYISYKEAKT 250 260 270 280 290 300 AAKLGMKVLH PRAIDPVEGK IPVILGKTRD LKFGTLISHE SQGIPIVTHK LLENHAEISV 310 320 330 340 350 VSVKTNIPLP YEVYEEGDLY FKIKTSKDQF LEVLRDVHRR VVENENLHSS HDGELWTWV

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 and OT3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA29952.1.
PIR	F71136.
RefSeq	NP_142788.1. NC_000961.1.
3D structure databases
ProteinModelPortal	O58588.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000001860; EBPYRP00000001860; EBPYRG00000001860.
GeneID	1443185.
GenomeReviews	Gene locus PH0858 in contig BA000001_GR.
KEGG	pho:PH0858.
NMPDR	fig|70601.1.peg.838.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022263.
HOGENOM	HBG645244.
OMA	GNLNGFR.
PhylomeDB	O58588.
ProtClustDB	PRK08373.
Enzyme and pathway databases
BioCyc	PHOR70601:PH0858-MONOMER.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. IPR011819. AspKin_pair. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 2 hits.
KO	K00928.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00657. Asp_kinases. 1 hit. TIGR02078. AspKin_pair. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O58588_PYRHO

Accession

Primary (citable) accession number: O58588

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)