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Protein

Uncharacterized DapA-like lyase PH0847

Gene

dapAL

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Charge relay systemBy similarity
Active sitei104 – 1041Charge relay systemBy similarity
Active sitei130 – 1301Proton donorBy similarity
Active sitei158 – 1581Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-843-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized DapA-like lyase PH0847 (EC:4.-.-.-)
Gene namesi
Name:dapAL
Ordered Locus Names:PH0847
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Uncharacterized DapA-like lyase PH0847PRO_0000103205Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0847.

Structurei

3D structure databases

ProteinModelPortaliO58577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.Curated

Phylogenomic databases

eggNOGiarCOG04172. Archaea.
COG0329. LUCA.
HOGENOMiHOG000173604.
KOiK01714.
OMAiHGIDMGP.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Schiff_base-form_aldolases_AS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
PROSITEiPS00666. DHDPS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVIVPLIT PFKEDHSIDF EALEWLIKFL EEKGVHGIFI NSTTGEFTSL
60 70 80 90 100
SLEERKILAE KGREVTSRTY LVGTGSTSTF EVIELTKHAK EIGADGVVIV
110 120 130 140 150
SPYYCRLKED AIFKHFSMVA EKVDIPIILY AIPSCANPIS LEVVRKLALE
160 170 180 190 200
YSNVIGVKAS VDSLTYLSGL IEIKEERKDF KVFTGLDQYF LPNLILGGDG
210 220 230 240 250
GIMACANFVP EIHLEVWNAF KKGNLEKAMN SARKLVKITK IYSIASSFAS
260 270 280
AVKLAMVARG FPIKPILRPP YMMDGEEVFK KIKEIVS
Length:287
Mass (Da):31,960
Last modified:August 1, 1998 - v1
Checksum:iB33D7F2D33180223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29941.1.
PIRiC71135.
RefSeqiWP_010884940.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29941; BAA29941; BAA29941.
GeneIDi1443175.
KEGGipho:PH0847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29941.1.
PIRiC71135.
RefSeqiWP_010884940.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO58577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29941; BAA29941; BAA29941.
GeneIDi1443175.
KEGGipho:PH0847.

Phylogenomic databases

eggNOGiarCOG04172. Archaea.
COG0329. LUCA.
HOGENOMiHOG000173604.
KOiK01714.
OMAiHGIDMGP.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-843-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR020625. Schiff_base-form_aldolases_AS.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
PROSITEiPS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiDAPAL_PYRHO
AccessioniPrimary (citable) accession number: O58577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.