ID   IORA_PYRHO              Reviewed;         648 AA.
AC   O58495;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=Indolepyruvate oxidoreductase subunit iorA;
DE            Short=IOR;
DE            EC=1.2.7.8;
DE   AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit alpha;
GN   Name=iorA; OrderedLocusNames=PH0765;
OS   Pyrococcus horikoshii.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=53953;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT3;
RX   MEDLINE=98344137; PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y.,
RA   Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y.,
RA   Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K.,
RA   Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative
CC       decarboxylation of arylpyruvates (By similarity).
CC   -!- CATALYTIC ACTIVITY: (Indol-3-yl)pyruvate + CoA + 2 oxidized
CC       ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster.
CC   -!- SUBUNIT: Heterodimer of the iorA and iorB subunits.
CC   -!- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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DR   EMBL; BA000001; BAA29856.1; -; Genomic_DNA.
DR   PIR; F71124; F71124.
DR   RefSeq; NP_142702.1; -.
DR   HSSP; O28604; 1JNR.
DR   GeneID; 1443091; -.
DR   GenomeReviews; BA000001_GR; PH0765.
DR   KEGG; pho:PH0765; -.
DR   NMPDR; fig|70601.1.peg.744; -.
DR   HOGENOM; O58495; -.
DR   OMA; O58495; VADDPSM.
DR   BRENDA; 1.2.7.8; 74679.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase ac...; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamin pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd_subgr.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017721; Indolepyruvate_Fd_OxRdtase_asu.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR011766; TPP_enzyme_bd_C.
DR   Pfam; PF00037; Fer4; 2.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   TIGRFAMs; TIGR03336; IOR_alpha; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Oxidoreductase; Repeat; Transport.
FT   CHAIN         1    648       Indolepyruvate oxidoreductase subunit
FT                                iorA.
FT                                /FTId=PRO_0000099929.
FT   DOMAIN      585    614       4Fe-4S ferredoxin-type 1.
FT   DOMAIN      616    645       4Fe-4S ferredoxin-type 2.
FT   METAL       625    625       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       628    628       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       631    631       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       635    635       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   648 AA;  71532 MW;  75A843815FCE08B1 CRC64;
     MVKVTDIVLW DKPGEKVLLL GNQAIVRGAL EGNIGVYAAY PGTPSSEITD TMAMVAKKAG
     VYMEYSTNEK VAFETALSAS WAGLRAMTAM KHVGLNVAMD SFMTVSYMGI NGGLIVVVAD
     DPSMWSSQNE QDTRAIAKFA NIPVLEPSSV QEAKDMVKYA FEISEKYGQM VILRTTTRSS
     HMRGDVVLGE LPQEIKEGKR KFGNFKKNPE KYVDIPAFQR PKHPWLLETI EKFREEFNTS
     PFNWIEGPED AKVGIIAPGL SYAYVKEALA WLGIDNVKIL KLGTPFPVPY GLLEKFFNGL
     ERVLIVEELE PVVEEQVKVW AFDNNINIEI HGKDLVPRVY EMTTRRAVEA VAKFLGVETP
     INFQEIDEKY KKVQEMVPPR PPSLCPACPH RNTFFAIRKA ATPRAIFPSD IGCYTLGVLP
     PLKTVDTTIA MGGSIGVAHG LSIALNGALG EEQRKTGKEK KIIVATIGDS TFFHTGLPAL
     ANAIYNRSNV LIVVMDNMVT AMTGDQPNPG TGETPHGPGK RILIEEVARA MGADFVAVVD
     PYDIKETYET IKKALEVEGV SVVVSRRACA LYRIGQLRRE GKQWPIYQVN EEKCTGCKIC
     INAYGCPAIY WDAEKKKARV DPLMCWGCGG CAQVCPFGAF EKVREGEL
//