Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O58489 (AAT_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate aminotransferase

Short name=AspAT
EC=2.6.1.1
Alternative name(s):
Transaminase A
Gene names
Name:aspC
Ordered Locus Names:PH0771
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Aspartate aminotransferase
PRO_0000123861

Sites

Binding site401Aspartate; via amide nitrogen By similarity
Binding site1761Aspartate By similarity
Binding site3661Aspartate By similarity

Amino acid modifications

Modified residue2361N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O58489 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: C35FD73BD08FE4C1

FASTA39144,565
        10         20         30         40         50         60 
MREKRKYFIA ERVLLIKRSK IRELFERASK MEDVISLGIG EPDFDTPKNI KEAAKRALDE 

        70         80         90        100        110        120 
GWTHYTPNAG IPELREAVVE YYKKFYGIDI EVENVIITAG AYEGTYLAFE SLLERGDEVI 

       130        140        150        160        170        180 
IPDPAFVSYA EDAKVAEAKP VRIPLREENN FLPDPNELLE KISKNTRMIV INYPNNPTGA 

       190        200        210        220        230        240 
TLDKELAKTI ADIAEDYNIY ILSDEPYEHF IYEDAKHYPM IKFAPENTIL ANSFSKTFAM 

       250        260        270        280        290        300 
TGWRLGFVVA PSQVIKEMTK LHAYVIGNVA SFVQIAGIEA LRSEESWKAV EEMKKEYNER 

       310        320        330        340        350        360 
RKIVVKRLKN MPGIKVKEPK GAFYVFPNIS GTGMSSEKFS EWLLEKARVV VIPGTAFGRM 

       370        380        390 
GEGYVRISYA TSKEKLIEAM NRIEKALEGE K 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000001 Genomic DNA. Translation: BAA29863.1.
PIRE71125.
RefSeqNP_142708.1. NC_000961.1.

3D structure databases

ProteinModelPortalO58489.
SMRO58489. Positions 21-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING70601.PH0771.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA29863; BAA29863; BAA29863.
GeneID1443098.
KEGGpho:PH0771.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0436.
HOGENOMHOG000223062.
KOK00812.
OMAMIVINYP.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-765-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAAT_PYRHO
AccessionPrimary (citable) accession number: O58489
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families