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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40Aspartate; via amide nitrogenBy similarity1
Binding sitei176AspartateBy similarity1
Binding sitei366AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-751-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:PH0771
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238611 – 391Aspartate aminotransferaseAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0771

Structurei

3D structure databases

ProteinModelPortaliO58489
SMRiO58489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01130 Archaea
COG0436 LUCA
HOGENOMiHOG000223062
KOiK00812
OMAiFYLYADV
OrthoDBiPOG093Z02O6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

O58489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREKRKYFIA ERVLLIKRSK IRELFERASK MEDVISLGIG EPDFDTPKNI
60 70 80 90 100
KEAAKRALDE GWTHYTPNAG IPELREAVVE YYKKFYGIDI EVENVIITAG
110 120 130 140 150
AYEGTYLAFE SLLERGDEVI IPDPAFVSYA EDAKVAEAKP VRIPLREENN
160 170 180 190 200
FLPDPNELLE KISKNTRMIV INYPNNPTGA TLDKELAKTI ADIAEDYNIY
210 220 230 240 250
ILSDEPYEHF IYEDAKHYPM IKFAPENTIL ANSFSKTFAM TGWRLGFVVA
260 270 280 290 300
PSQVIKEMTK LHAYVIGNVA SFVQIAGIEA LRSEESWKAV EEMKKEYNER
310 320 330 340 350
RKIVVKRLKN MPGIKVKEPK GAFYVFPNIS GTGMSSEKFS EWLLEKARVV
360 370 380 390
VIPGTAFGRM GEGYVRISYA TSKEKLIEAM NRIEKALEGE K
Length:391
Mass (Da):44,565
Last modified:August 1, 1998 - v1
Checksum:iC35FD73BD08FE4C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29863.1
PIRiE71125
RefSeqiWP_010884863.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29863; BAA29863; BAA29863
GeneIDi1443098
KEGGipho:PH0771

Similar proteinsi

Entry informationi

Entry nameiAAT_PYRHO
AccessioniPrimary (citable) accession number: O58489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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