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O58489

- AAT_PYRHO

UniProt

O58489 - AAT_PYRHO

Protein

Aspartate aminotransferase

Gene

aspC

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401Aspartate; via amide nitrogenBy similarity
    Binding sitei176 – 1761AspartateBy similarity
    Binding sitei366 – 3661AspartateBy similarity

    GO - Molecular functioni

    1. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-765-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate aminotransferase (EC:2.6.1.1)
    Short name:
    AspAT
    Alternative name(s):
    Transaminase A
    Gene namesi
    Name:aspC
    Ordered Locus Names:PH0771
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Aspartate aminotransferasePRO_0000123861Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei236 – 2361N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi70601.PH0771.

    Structurei

    3D structure databases

    ProteinModelPortaliO58489.
    SMRiO58489. Positions 21-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223062.
    KOiK00812.
    OMAiMIVINYP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O58489-1 [UniParc]FASTAAdd to Basket

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    MREKRKYFIA ERVLLIKRSK IRELFERASK MEDVISLGIG EPDFDTPKNI    50
    KEAAKRALDE GWTHYTPNAG IPELREAVVE YYKKFYGIDI EVENVIITAG 100
    AYEGTYLAFE SLLERGDEVI IPDPAFVSYA EDAKVAEAKP VRIPLREENN 150
    FLPDPNELLE KISKNTRMIV INYPNNPTGA TLDKELAKTI ADIAEDYNIY 200
    ILSDEPYEHF IYEDAKHYPM IKFAPENTIL ANSFSKTFAM TGWRLGFVVA 250
    PSQVIKEMTK LHAYVIGNVA SFVQIAGIEA LRSEESWKAV EEMKKEYNER 300
    RKIVVKRLKN MPGIKVKEPK GAFYVFPNIS GTGMSSEKFS EWLLEKARVV 350
    VIPGTAFGRM GEGYVRISYA TSKEKLIEAM NRIEKALEGE K 391
    Length:391
    Mass (Da):44,565
    Last modified:August 1, 1998 - v1
    Checksum:iC35FD73BD08FE4C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29863.1.
    PIRiE71125.
    RefSeqiNP_142708.1. NC_000961.1.
    WP_010884863.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA29863; BAA29863; BAA29863.
    GeneIDi1443098.
    KEGGipho:PH0771.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29863.1 .
    PIRi E71125.
    RefSeqi NP_142708.1. NC_000961.1.
    WP_010884863.1. NC_000961.1.

    3D structure databases

    ProteinModelPortali O58489.
    SMRi O58489. Positions 21-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH0771.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA29863 ; BAA29863 ; BAA29863 .
    GeneIDi 1443098.
    KEGGi pho:PH0771.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223062.
    KOi K00812.
    OMAi MIVINYP.

    Enzyme and pathway databases

    BioCyci PHOR70601:GJWR-765-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiAAT_PYRHO
    AccessioniPrimary (citable) accession number: O58489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3