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Protein

FAD synthase

Gene

ribL

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. FAD synthase (ribL)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 15ATPUniRule annotation2
Nucleotide bindingi19 – 22ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-719-MONOMER
UniPathwayiUPA00277; UER00407

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
Alternative name(s):
FMN adenylyltransferaseUniRule annotation
Flavin adenine dinucleotide synthaseUniRule annotation
Gene namesi
Name:ribLUniRule annotation
Ordered Locus Names:PH0735
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004062811 – 148FAD synthaseAdd BLAST148

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0735

Structurei

3D structure databases

ProteinModelPortaliO58466
SMRiO58466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal FAD synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01222 Archaea
COG0615 LUCA
HOGENOMiHOG000284153
KOiK14656
OMAiVAHDETV
OrthoDBiPOG093Z0AQ4

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_02115 FAD_synth_arch, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR024902 FAD_synth_RibL
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

O58466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSDRKIRVV VGGVFDIIHA GHVHFLKMAK ELGDELIVIV AHDETVKKRK
60 70 80 90 100
GRPPINPAED RAEVLKAIRY VDDVVIGKPG EISLDLIKRL KPDVIALGPD
110 120 130 140
QDFDCEDLKR KLKSIGLNVE VIRLPYLYKK DRAKTSKIIE RITEIFCD
Length:148
Mass (Da):16,737
Last modified:August 1, 1998 - v1
Checksum:i07F566C19188FE38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29826.1
PIRiH71120
RefSeqiWP_010884831.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29826; BAA29826; BAA29826
GeneIDi1443066
KEGGipho:PH0735

Similar proteinsi

Entry informationi

Entry nameiRIBL_PYRHO
AccessioniPrimary (citable) accession number: O58466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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