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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84Carbamoyl phosphateUniRule annotation1
Binding sitei108Carbamoyl phosphateUniRule annotation1
Binding sitei166OrnithineUniRule annotation1
Binding sitei230OrnithineUniRule annotation1
Binding sitei298Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-712-MONOMER
UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argFUniRule annotation
Ordered Locus Names:PH0726
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001130742 – 317Ornithine carbamoyltransferaseAdd BLAST316

Interactioni

Subunit structurei

Homododecamer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0726

Structurei

3D structure databases

ProteinModelPortaliO58457
SMRiO58457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 60Carbamoyl phosphate bindingUniRule annotation4
Regioni135 – 138Carbamoyl phosphate bindingUniRule annotation4
Regioni234 – 235Ornithine bindingUniRule annotation2
Regioni270 – 271Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00912 Archaea
COG0078 LUCA
HOGENOMiHOG000022686
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG093Z05BF

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O58457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSLKGRDL LCLQDYTPEE IWTILETAKM FKIWQKIGKP HRLLEGKTLA
60 70 80 90 100
MIFQKPSTRT RVSFEVAMAH LGGHALYLNA QDLQLRRGET IADTARVLSR
110 120 130 140 150
YVDAIMARVY AHKDVEDLAK YASVPVINGL SDFSHPCQAL ADYMTIWEKK
160 170 180 190 200
GTIKGVKVVY VGDGNNVCHS LMIAGTKLGA DVVVATPEGY EPDKKVIKWA
210 220 230 240 250
EQNAAESGGS FELLHDPVKA VKDADVIYTD VWASMGQEAE AEERRKIFRP
260 270 280 290 300
FQVNKDLVKH AKSDYMFMHC LPAHRGEEVT DDVIDSPNSV VWDEAENRLH
310
AQKAVLALLL GGVKTGF
Length:317
Mass (Da):35,369
Last modified:January 23, 2007 - v3
Checksum:iD949989E0E8F6B1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29817.1
PIRiG71119
RefSeqiWP_010884824.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29817; BAA29817; BAA29817
GeneIDi1443059
KEGGipho:PH0726

Similar proteinsi

Entry informationi

Entry nameiOTC_PYRHO
AccessioniPrimary (citable) accession number: O58457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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