O58452 (PYRI_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase regulatory chain

Gene names

Name:	pyrI
Ordered Locus Names:	PH0721

Organism

Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]

Taxonomic identifier

70601 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in allosteric regulation of aspartate carbamoyltransferase By similarity. HAMAP MF_00002
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00002
Subunit structure	Contains catalytic and regulatory chains.
Sequence similarities	Belongs to the pyrI family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	aspartate carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	Aspartate carbamoyltransferase regulatory chain HAMAP MF_00002		PRO_0000142340
Sites
	Metal binding	108	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity
	Metal binding	136	1	Zinc By similarity
	Metal binding	139	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	O58452 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: BBE0CDC082894378	FASTA	152	16,872
	10 20 30 40 50 60 MPELKVSAIK EGTVIDHIPA GKGLKVIEIL GLSKLSNGGS VLLAMNVPSK KLGRKDIVKV 70 80 90 100 110 120 EGKFLSEEEV NKIALVAPTA TVNIIRNYKV VEKFKVEVPE VIEGILKCGN PNCITNYEYV 130 140 150 TTKFYVISKN PLKVRCHYCE RTMEEEEILA NL

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA29812.1.
PIR	B71119.
RefSeq	NP_142666.1. NC_000961.1.
3D structure databases
ProteinModelPortal	O58452.
SMR	O58452. Positions 5-146.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000000032; EBPYRP00000000032; EBPYRG00000000032.
GeneID	1443054.
GenomeReviews	Gene locus PH0721 in contig BA000001_GR.
KEGG	pho:PH0721.
NMPDR	fig|70601.1.peg.707.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000023132.
HOGENOM	HBG305327.
OMA	TVIDHIT.
PhylomeDB	O58452.
ProtClustDB	PRK00893.
Enzyme and pathway databases
BioCyc	PHOR70601:PH0721-MONOMER.
Family and domain databases
HAMAP	MF_00002. Asp_carb_tr_reg. [Tree]
InterPro	IPR020545. Asp_carbamoyltransf_reg_N. IPR002801. Asp_carbamoylTrfase_reg. IPR020542. Asp_carbamoyltrfase_reg_C. [Graphical view]
Gene3D	G3DSA:2.30.30.20. PyrI. 1 hit. G3DSA:3.30.70.140. PyrI. 1 hit.
KO	K00610.
Pfam	PF01948. PyrI. 1 hit. PF02748. PyrI_C. 1 hit. [Graphical view]
ProDom	PD006194. Asp_carbamoylTrfase_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54893. Asp_carbamoylTrfase_reg. 1 hit. SSF57825. Asp_transf_reg_C. 1 hit.
TIGRFAMs	TIGR00240. ATCase_reg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRI_PYRHO

Accession

Primary (citable) accession number: O58452

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program