O58417 (PORB_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate synthase subunit porB
EC=1.2.7.1

Alternative name(s):
Pyruvate oxidoreductase beta chain
Short name=POR
Pyruvic-ferredoxin oxidoreductase subunit beta

Gene names

Name:	porB
Ordered Locus Names:	PH0685

Organism

Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]

Taxonomic identifier

70601 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity.
Sequence caution	The sequence BAA29776.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 331	330	Pyruvate synthase subunit porB		PRO_0000099908

Sequences

	Sequence		Length	Mass (Da)
	O58417 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2E5FDCE5B6791C25	FASTA	331	36,119
	10 20 30 40 50 60 MAVRKPPITT REYWAPGHAA CAGCGCAIAL KLATKAFSEA MEEKYGDPNA FAIAQATGCM 70 80 90 100 110 120 EVVSAVFPYT AWKVPWIHVA FENAAAAASG VEAAWKKLGI KGKILAIGGD GGTADIGLQA 130 140 150 160 170 180 LSGMLERGHN VVYLMYDNEA YMNTGIQRSS STPYGAWTTT SPPGKYSIGE DRPKKWVALI 190 200 210 220 230 240 AAAHQIPYAA TASIGNPFDL VKKVKKAAKV DGPAFIQVHC TCPTGWRTPL EKGVEIARLA 250 260 270 280 290 300 IETGMWPLFE IENGDIWNIK IQPPGGGAKV YKEGGRVVRI EFKKPIEEYL KYQGRFKHLF 310 320 330 KRPEAIEELR NQIKAMWKVL GVEAILPRPE E

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA29776.1. Different initiation.
PIR	F71114.
RefSeq	NP_142634.1. NC_000961.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000000365; EBPYRP00000000365; EBPYRG00000000365.
GeneID	1443012.
GenomeReviews	Gene locus PH0685 in contig BA000001_GR.
KEGG	pho:PH0685.
NMPDR	fig|70601.1.peg.665.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022253.
HOGENOM	HBG313203.
OMA	SPCTTEW.
ProtClustDB	PRK11865.
Enzyme and pathway databases
BioCyc	PHOR70601:PH0685-MONOMER.
Family and domain databases
InterPro	IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K00170.
Pfam	PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORB_PYRHO

Accession

Primary (citable) accession number: O58417

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program