ID   VORA_PYRHO              Reviewed;         394 AA.
AC   O58413;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   05-MAY-2009, entry version 47.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit vorA;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate oxidoreductase alpha chain;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit alpha;
GN   Name=vorA; OrderedLocusNames=PH0680;
OS   Pyrococcus horikoshii.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=53953;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT3;
RX   MEDLINE=98344137; PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y.,
RA   Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y.,
RA   Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K.,
RA   Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one
CC       gamma chain (By similarity).
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DR   EMBL; BA000001; BAA29771.1; ALT_INIT; Genomic_DNA.
DR   PIR; A71114; A71114.
DR   RefSeq; NP_142630.1; -.
DR   GeneID; 1443008; -.
DR   GenomeReviews; BA000001_GR; PH0680.
DR   KEGG; pho:PH0680; -.
DR   NMPDR; fig|70601.1.peg.661; -.
DR   HOGENOM; O58413; -.
DR   OMA; O58413; AFILSHT.
DR   BRENDA; 1.2.7.7; 74679.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR015941; Transketolase_C-like.
DR   Gene3D; G3DSA:3.40.50.920; Transketo_C_like; 1.
DR   Pfam; PF01855; POR_N; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase.
FT   CHAIN         1    394       Ketoisovalerate oxidoreductase subunit
FT                                vorA.
FT                                /FTId=PRO_0000099953.
SQ   SEQUENCE   394 AA;  44126 MW;  68E5038B32D63FD3 CRC64;
     MEYNPIKKVV SGNYAAAYAA LHARVQVVAA YPITPQTSII EKIAEFIANG EADIQYIPVE
     SEHSAMAACI GASATGARVF TATSAQGLAL MHEMLHWAAG SRLPIVMVNV NRAMAPPWSV
     WDDQTDSLSQ RDTGWMQFYA ENNQEVYDGV LMAYKVAETV NIPTMIIESA FILSHTYEVV
     NMIPQELVDE FLPPRKPLYT LTDFENPIAV GALATPADYY EFRYKIAKAH EEAKKVIKSV
     GKEFGERFGR DYSKMIETGY IEDADFVFMG MGSLMGTVKE AVDLLRKEGY KVGYAKVRWF
     RPFPKEELLE IAESVKGIAV LDRNFSFGQE GILFTEAKGA LYNTGVRPIM KDYIVGLGGR
     DFTVRDVKAI AEDMKKVVES GKLDKEIEWY HLKR
//