O58413 (VORA_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketoisovalerate oxidoreductase subunit vorA
Short name=VOR
EC=1.2.7.7

Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit alpha
2-oxoisovalerate oxidoreductase alpha chain

Gene names

Name:	vorA
Ordered Locus Names:	PH0680

Organism

Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]

Taxonomic identifier

70601 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity.
Sequence caution	The sequence BAA29771.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Ketoisovalerate oxidoreductase subunit vorA		PRO_0000099953

Sequences

	Sequence		Length	Mass (Da)
	O58413 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 68E5038B32D63FD3	FASTA	394	44,126
	10 20 30 40 50 60 MEYNPIKKVV SGNYAAAYAA LHARVQVVAA YPITPQTSII EKIAEFIANG EADIQYIPVE 70 80 90 100 110 120 SEHSAMAACI GASATGARVF TATSAQGLAL MHEMLHWAAG SRLPIVMVNV NRAMAPPWSV 130 140 150 160 170 180 WDDQTDSLSQ RDTGWMQFYA ENNQEVYDGV LMAYKVAETV NIPTMIIESA FILSHTYEVV 190 200 210 220 230 240 NMIPQELVDE FLPPRKPLYT LTDFENPIAV GALATPADYY EFRYKIAKAH EEAKKVIKSV 250 260 270 280 290 300 GKEFGERFGR DYSKMIETGY IEDADFVFMG MGSLMGTVKE AVDLLRKEGY KVGYAKVRWF 310 320 330 340 350 360 RPFPKEELLE IAESVKGIAV LDRNFSFGQE GILFTEAKGA LYNTGVRPIM KDYIVGLGGR 370 380 390 DFTVRDVKAI AEDMKKVVES GKLDKEIEWY HLKR

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000001 Genomic DNA. Translation: BAA29771.1. Different initiation.
PIR	A71114.
RefSeq	NP_142630.1. NC_000961.1.
3D structure databases
ProteinModelPortal	O58413.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1501510.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000001151; EBPYRP00000001151; EBPYRG00000001151.
GeneID	1443008.
GenomeReviews	Gene locus PH0680 in contig BA000001_GR.
KEGG	pho:PH0680.
NMPDR	fig|70601.1.peg.661.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000022252.
HOGENOM	HBG313202.
OMA	EADIQYI.
ProtClustDB	PRK08366.
Enzyme and pathway databases
BioCyc	PHOR70601:PH0680-MONOMER.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K00186.
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VORA_PYRHO

Accession

Primary (citable) accession number: O58413

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 16, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program