ID   VORD_PYRHO              Reviewed;         105 AA.
AC   O58412;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit vorD;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate oxidoreductase delta chain;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit delta;
GN   Name=vorD; OrderedLocusNames=PH0679;
OS   Pyrococcus horikoshii.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=53953;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT3;
RX   MEDLINE=98344137; PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y.,
RA   Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y.,
RA   Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K.,
RA   Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 2 4Fe-4S clusters (By similarity).
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one
CC       gamma chain (By similarity).
CC   -!- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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DR   EMBL; BA000001; BAA29770.1; -; Genomic_DNA.
DR   PIR; H71113; H71113.
DR   RefSeq; NP_142629.1; -.
DR   HSSP; P00195; 1CLF.
DR   GeneID; 1443007; -.
DR   GenomeReviews; BA000001_GR; PH0679.
DR   KEGG; pho:PH0679; -.
DR   NMPDR; fig|70601.1.peg.660; -.
DR   HOGENOM; O58412; -.
DR   OMA; O58412; DEYPEAP.
DR   BRENDA; 1.2.7.7; 74679.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd_subgr.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR011898; PorD_KorD.
DR   Pfam; PF00037; Fer4; 2.
DR   TIGRFAMs; TIGR02179; PorD_KorD; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Oxidoreductase; Repeat; Transport.
FT   CHAIN         1    105       Ketoisovalerate oxidoreductase subunit
FT                                vorD.
FT                                /FTId=PRO_0000099963.
FT   DOMAIN       44     73       4Fe-4S ferredoxin-type 1.
FT   DOMAIN       74    103       4Fe-4S ferredoxin-type 2.
FT   METAL        53     53       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        56     56       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        59     59       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        63     63       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        83     83       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        86     86       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        89     89       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        93     93       Iron-sulfur 1 (4Fe-4S) (Potential).
SQ   SEQUENCE   105 AA;  11861 MW;  954AA31F09653FA1 CRC64;
     MNTLFGKAKE EAKPITPKSV DEYPEAPVSL GITLVNFTGD WRTFMPVIDE SKCVKCYICW
     KYCPEPAIYI KEDGFVAIDY DYCKGCGICA NECPTKAITM VREEK
//