O58412 (VORD_PYRHO) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ketoisovalerate oxidoreductase subunit vorD Short name=VOR EC=1.2.7.7 Alternative name(s): 2-oxoisovalerate ferredoxin reductase subunit delta 2-oxoisovalerate oxidoreductase delta chain | ||||
| Gene names |
| ||||
| Organism | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 70601 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 105 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+. |
| Cofactor | Binds 2 4Fe-4S clusters By similarity. |
| Subunit structure | Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity. |
| Sequence similarities | Contains 2 4Fe-4S ferredoxin-type domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Domain | Repeat |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC 4 iron, 4 sulfur cluster bindingInferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 105 | 105 | Ketoisovalerate oxidoreductase subunit vorD | PRO_0000099963 | |||||
Regions | |||||||||
| Domain | 44 – 73 | 30 | 4Fe-4S ferredoxin-type 1 | ||||||
| Domain | 74 – 103 | 30 | 4Fe-4S ferredoxin-type 2 | ||||||
Sites | |||||||||
| Metal binding | 53 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 56 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 59 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 63 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 83 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 86 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 89 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 93 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
Sequences
References
| [1] | "Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. Kikuchi H.DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000001 Genomic DNA. Translation: BAA29770.1. |
| PIR | H71113. |
| RefSeq | NP_142629.1. NC_000961.1. |
3D structure databases | |
| ProteinModelPortal | O58412. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBPYRT00000000083; EBPYRP00000000083; EBPYRG00000000083. |
| GeneID | 1443007. |
| GenomeReviews | Gene locus PH0679 in contig BA000001_GR. |
| KEGG | pho:PH0679. |
| NMPDR | fig|70601.1.peg.660. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000022662. |
| HOGENOM | HBG734156. |
| OMA | KCYICWK. |
| ProtClustDB | PRK09623. |
Enzyme and pathway databases | |
| BioCyc | PHOR70601:PH0679-MONOMER. |
Family and domain databases | |
| InterPro | IPR001450. 4Fe4S-bd_dom. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR011898. PorD_KorD. [Graphical view] |
| KO | K00188. |
| Pfam | PF00037. Fer4. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR02179. PorD_KorD. 1 hit. |
| PROSITE | PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | VORD_PYRHO | ||||||||
| Accession | Primary (citable) accession number: O58412 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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