Reviewed,
UniProtKB/Swiss-Prot O58412 (VORD_PYRHO)
Last modified
February 9, 2010.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ketoisovalerate oxidoreductase subunit vorD Short name=VOR EC=1.2.7.7 Alternative name(s): 2-oxoisovalerate oxidoreductase delta chain 2-oxoisovalerate ferredoxin reductase subunit delta | ||||
| Gene names |
| ||||
| Organism | Pyrococcus horikoshii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 53953 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 105 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+. |
| Cofactor | Binds 2 4Fe-4S clusters By similarity. |
| Subunit structure | Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity. |
| Sequence similarities | Contains 2 4Fe-4S ferredoxin-type domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Domain | Repeat |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC 4 iron, 4 sulfur cluster bindingInferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 105 | 105 | Ketoisovalerate oxidoreductase subunit vorD | PRO_0000099963 | |||||
Regions | |||||||||
| Domain | 44 – 73 | 30 | 4Fe-4S ferredoxin-type 1 | ||||||
| Domain | 74 – 103 | 30 | 4Fe-4S ferredoxin-type 2 | ||||||
Sites | |||||||||
| Metal binding | 53 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 56 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 59 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 63 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 83 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 86 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 89 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 93 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
Sequences
References
| [1] | "Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. Kikuchi H.DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000001 Genomic DNA. Translation: BAA29770.1. |
| PIR | H71113. |
| RefSeq | NP_142629.1. |
3D structure databases | |
| SMR | O58412. Positions 40-102. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1443007. |
| GenomeReviews | Gene locus PH0679 in contig BA000001_GR. |
| KEGG | pho:PH0679. |
| NMPDR | fig|70601.1.peg.660. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG734156. |
| OMA | VDYEYCK. |
Enzyme and pathway databases | |
| BioCyc | PHOR70601:PH0679-MONOMER. |
| BRENDA | 1.2.7.7. 74679. |
Family and domain databases | |
| InterPro | IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR011898. PorD_KorD. [Graphical view] |
| TIGRFAMs | TIGR02179. PorD_KorD. 1 hit. |
| PROSITE | PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | VORD_PYRHO | ||||||||
| Accession | Primary (citable) accession number: O58412 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


