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Protein

Ketoisovalerate oxidoreductase subunit VorD

Gene

vorD

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron-sulfur 1 (4Fe-4S)Sequence analysis
Metal bindingi56 – 561Iron-sulfur 1 (4Fe-4S)Sequence analysis
Metal bindingi59 – 591Iron-sulfur 1 (4Fe-4S)Sequence analysis
Metal bindingi63 – 631Iron-sulfur 2 (4Fe-4S)Sequence analysis
Metal bindingi83 – 831Iron-sulfur 2 (4Fe-4S)Sequence analysis
Metal bindingi86 – 861Iron-sulfur 2 (4Fe-4S)Sequence analysis
Metal bindingi89 – 891Iron-sulfur 2 (4Fe-4S)Sequence analysis
Metal bindingi93 – 931Iron-sulfur 1 (4Fe-4S)Sequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketoisovalerate oxidoreductase subunit VorD (EC:1.2.7.7)
Short name:
VOR
Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit delta
2-oxoisovalerate oxidoreductase delta chain
Gene namesi
Name:vorD
Ordered Locus Names:PH0679
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Ketoisovalerate oxidoreductase subunit VorDPRO_0000099963Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of one alpha, one beta, one delta and one gamma chain.By similarity

Protein-protein interaction databases

STRINGi70601.PH0679.

Structurei

3D structure databases

ProteinModelPortaliO58412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 73304Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini74 – 103304Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01605. Archaea.
COG1144. LUCA.
HOGENOMiHOG000044614.
KOiK00188.
OMAiKSVDEYP.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011898. PorD_KorD.
[Graphical view]
TIGRFAMsiTIGR02179. PorD_KorD. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLFGKAKE EAKPITPKSV DEYPEAPVSL GITLVNFTGD WRTFMPVIDE
60 70 80 90 100
SKCVKCYICW KYCPEPAIYI KEDGFVAIDY DYCKGCGICA NECPTKAITM

VREEK
Length:105
Mass (Da):11,861
Last modified:August 1, 1998 - v1
Checksum:i954AA31F09653FA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29770.1.
PIRiH71113.
RefSeqiWP_010884772.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29770; BAA29770; BAA29770.
GeneIDi1443007.
KEGGipho:PH0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29770.1.
PIRiH71113.
RefSeqiWP_010884772.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO58412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29770; BAA29770; BAA29770.
GeneIDi1443007.
KEGGipho:PH0679.

Phylogenomic databases

eggNOGiarCOG01605. Archaea.
COG1144. LUCA.
HOGENOMiHOG000044614.
KOiK00188.
OMAiKSVDEYP.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-671-MONOMER.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011898. PorD_KorD.
[Graphical view]
TIGRFAMsiTIGR02179. PorD_KorD. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiVORD_PYRHO
AccessioniPrimary (citable) accession number: O58412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: December 9, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.