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Protein

Ketoisovalerate oxidoreductase subunit VorD

Gene

vorD

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi56Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi59Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi63Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi83Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi86Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi89Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi93Iron-sulfur 1 (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-661-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ketoisovalerate oxidoreductase subunit VorD (EC:1.2.7.7)
Short name:
VOR
Alternative name(s):
2-oxoisovalerate ferredoxin reductase subunit delta
2-oxoisovalerate oxidoreductase delta chain
Gene namesi
Name:vorD
Ordered Locus Names:PH0679
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000999631 – 105Ketoisovalerate oxidoreductase subunit VorDAdd BLAST105

Proteomic databases

PRIDEiO58412

Interactioni

Subunit structurei

Heterotetramer of one alpha, one beta, one delta and one gamma chain.By similarity

Protein-protein interaction databases

STRINGi70601.PH0679

Structurei

3D structure databases

ProteinModelPortaliO58412
SMRiO58412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 734Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini74 – 1034Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01605 Archaea
COG1144 LUCA
HOGENOMiHOG000044614
KOiK00188
OMAiLYCPESV
OrthoDBiPOG093Z033F

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR011898 PorD_KorD
PANTHERiPTHR43724 PTHR43724, 1 hit
TIGRFAMsiTIGR02179 PorD_KorD, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

O58412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLFGKAKE EAKPITPKSV DEYPEAPVSL GITLVNFTGD WRTFMPVIDE
60 70 80 90 100
SKCVKCYICW KYCPEPAIYI KEDGFVAIDY DYCKGCGICA NECPTKAITM

VREEK
Length:105
Mass (Da):11,861
Last modified:August 1, 1998 - v1
Checksum:i954AA31F09653FA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29770.1
PIRiH71113
RefSeqiWP_010884772.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29770; BAA29770; BAA29770
GeneIDi1443007
KEGGipho:PH0679

Similar proteinsi

Entry informationi

Entry nameiVORD_PYRHO
AccessioniPrimary (citable) accession number: O58412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health