Reviewed, UniProtKB/Swiss-Prot O58411 (PORC_PYRHO)

Names and origin

Protein names

Recommended name:
    Pyruvate/ketoisovalerate oxidoreductases common subunit gamma
Including the following 2 domains:
    1- Recommended name:
            Pyruvate synthase subunit porC
              EC=1.2.7.1
        Alternative name(s):
            Pyruvate oxidoreductase gamma chain
              Short name=POR
            Pyruvic-ferredoxin oxidoreductase subunit gamma
    2- Recommended name:
            Ketoisovalerate oxidoreductase subunit vorC
                Short name=VOR
              EC=1.2.7.7
        Alternative name(s):
            2-oxoisovalerate oxidoreductase gamma chain
            2-oxoisovalerate ferredoxin reductase subunit gamma

Gene names

Name:	porG
Ordered Locus Names:	PH0678

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+). 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Pyruvate/ketoisovalerate oxidoreductases common subunit gamma		PRO_0000099915

Sequences

	Sequence		Length	Mass (Da)
	O58411-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 99F746D9E801D0A6	FASTA	185	20,051
	10 20 30 40 50 60 MIEIRFHGRG GQGAVTAANI LAEAAFLEGK YVQAFPFFGV ERRGAPVTAF TRIDEKPIRI 70 80 90 100 110 120 KTQIYEPDIV VVLDPSLLET VDVTAGLKEE GIVIINTEKS KDEILEKLKK KPKKLALVDA 130 140 150 160 170 180 TTIALETLGL PITNTAILGA VAKATGLVNI ESVEKAIKDT FSGELGEKNA KAAREAFEKT EIFEV

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000001 Genomic DNA. Translation: BAA29769.1.
PIR	G71113.
RefSeq	NP_142628.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1443006.
GenomeReviews	Gene locus PH0678 in contig BA000001_GR.
KEGG	pho:PH0678.
NMPDR	fig|70601.1.peg.659.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O58411.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR002869. Pyrv_Fd/Flavodoxin_OxRdtase. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
Pfam	PF01558. POR. 1 hit. [Graphical view]
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_PYRHO

Accession

Primary (citable) accession number: O58411

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 25, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)