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O58403

- O58403_PYRHO

UniProt

O58403 - O58403_PYRHO

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Protein
Submitted name: 228aa long hypothetical aspartate racemase
Gene
PH0670
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Citrate 1; via carbonyl oxygen
Active sitei82 – 821Proton donor/acceptorImported
Binding sitei160 – 1601Citrate 1
Binding sitei164 – 1641Citrate 1
Binding sitei188 – 1881Citrate 2
Active sitei194 – 1941Proton donor/acceptorImported
Binding sitei195 – 1951Citrate 1; via amide nitrogen

GO - Molecular functioni

  1. racemase activity, acting on amino acids and derivatives Source: InterPro

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-661-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
228aa long hypothetical aspartate racemaseImported
Gene namesi
Ordered Locus Names:PH0670Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0670.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IU9X-ray2.04A103-213[»]
1JFLX-ray1.90A/B1-228[»]
2DX7X-ray2.00A/B1-228[»]
ProteinModelPortaliO58403.
SMRiO58403. Positions 1-228.

Miscellaneous databases

EvolutionaryTraceiO58403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni47 – 493Citrate 1 binding
Regioni83 – 853Citrate 1 binding
Regioni115 – 1173Citrate 2 binding

Phylogenomic databases

eggNOGiCOG1794.
HOGENOMiHOG000262147.
KOiK01779.
OMAiCNVILLG.

Family and domain databases

Gene3Di3.40.50.1860. 2 hits.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS.
IPR004380. Asp_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00035. asp_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58403-1 [UniParc]FASTAAdd to Basket

« Hide

MKTIGILGGM GPLATAELFR RIVIKTPAKR DQEHPKVIIF NNPQIPDRTA    50
YILGKGEDPR PQLIWTAKRL EECGADFIIM PCNTAHAFVE DIRKAIKIPI 100
ISMIEETAKK VKELGFKKAG LLATTGTIVS GVYEKEFSKY GVEIMTPTED 150
EQKDVMRGIY EGVKAGNLKL GRELLLKTAK ILEERGAECI IAGCTEVSVV 200
LKQDDLKVPL IDPMDVIAEV AVKVALEK 228
Length:228
Mass (Da):25,158
Last modified:August 1, 1998 - v1
Checksum:iDDAA2CBEB39682CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA29761.1.
PIRiG71112.
RefSeqiNP_142620.1. NC_000961.1.
WP_010884762.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29761; BAA29761; BAA29761.
GeneIDi1442997.
KEGGipho:PH0670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA29761.1 .
PIRi G71112.
RefSeqi NP_142620.1. NC_000961.1.
WP_010884762.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IU9 X-ray 2.04 A 103-213 [» ]
1JFL X-ray 1.90 A/B 1-228 [» ]
2DX7 X-ray 2.00 A/B 1-228 [» ]
ProteinModelPortali O58403.
SMRi O58403. Positions 1-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA29761 ; BAA29761 ; BAA29761 .
GeneIDi 1442997.
KEGGi pho:PH0670.

Phylogenomic databases

eggNOGi COG1794.
HOGENOMi HOG000262147.
KOi K01779.
OMAi CNVILLG.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-661-MONOMER.

Miscellaneous databases

EvolutionaryTracei O58403.

Family and domain databases

Gene3Di 3.40.50.1860. 2 hits.
InterProi IPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS.
IPR004380. Asp_race.
[Graphical view ]
Pfami PF01177. Asp_Glu_race. 1 hit.
[Graphical view ]
SUPFAMi SSF53681. SSF53681. 2 hits.
TIGRFAMsi TIGR00035. asp_race. 1 hit.
PROSITEi PS00923. ASP_GLU_RACEMASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.
  2. "Structural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemases."
    Liu L., Iwata K., Yohda M., Miki K.
    FEBS Lett. 528:114-118(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 103-213.
  3. "Crystal structure of aspartate racemase from Pyrococcus horikoshii OT3 and its implications for molecular mechanism of PLP-independent racemization."
    Liu L., Iwata K., Kita A., Kawarabayasi Y., Yohda M., Miki K.
    J. Mol. Biol. 319:479-489(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS), ACTIVE SITE.
  4. "Structure of aspartate racemase complexed with a dual substrate analogue, citric acid, and implications for the reaction mechanism."
    Ohtaki A., Nakano Y., Iizuka R., Arakawa T., Yamada K., Odaka M., Yohda M.
    Proteins 70:1167-1174(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).

Entry informationi

Entry nameiO58403_PYRHO
AccessioniPrimary (citable) accession number: O58403
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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