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O58403

- O58403_PYRHO

UniProt

O58403 - O58403_PYRHO

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Protein
Submitted name:

228aa long hypothetical aspartate racemase

Gene

PH0670

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. racemase activity, acting on amino acids and derivatives Source: InterPro

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-661-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
228aa long hypothetical aspartate racemaseImported
Gene namesi
Ordered Locus Names:PH0670Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0670.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IU9X-ray2.04A103-213[»]
1JFLX-ray1.90A/B1-228[»]
2DX7X-ray2.00A/B1-228[»]
ProteinModelPortaliO58403.
SMRiO58403. Positions 1-228.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58403.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1794.
HOGENOMiHOG000262147.
KOiK01779.
OMAiCNVILLG.

Family and domain databases

Gene3Di3.40.50.1860. 2 hits.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS.
IPR004380. Asp_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00035. asp_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58403-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTIGILGGM GPLATAELFR RIVIKTPAKR DQEHPKVIIF NNPQIPDRTA
60 70 80 90 100
YILGKGEDPR PQLIWTAKRL EECGADFIIM PCNTAHAFVE DIRKAIKIPI
110 120 130 140 150
ISMIEETAKK VKELGFKKAG LLATTGTIVS GVYEKEFSKY GVEIMTPTED
160 170 180 190 200
EQKDVMRGIY EGVKAGNLKL GRELLLKTAK ILEERGAECI IAGCTEVSVV
210 220
LKQDDLKVPL IDPMDVIAEV AVKVALEK
Length:228
Mass (Da):25,158
Last modified:August 1, 1998 - v1
Checksum:iDDAA2CBEB39682CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29761.1.
PIRiG71112.
RefSeqiNP_142620.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29761; BAA29761; BAA29761.
GeneIDi1442997.
KEGGipho:PH0670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29761.1 .
PIRi G71112.
RefSeqi NP_142620.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IU9 X-ray 2.04 A 103-213 [» ]
1JFL X-ray 1.90 A/B 1-228 [» ]
2DX7 X-ray 2.00 A/B 1-228 [» ]
ProteinModelPortali O58403.
SMRi O58403. Positions 1-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA29761 ; BAA29761 ; BAA29761 .
GeneIDi 1442997.
KEGGi pho:PH0670.

Phylogenomic databases

eggNOGi COG1794.
HOGENOMi HOG000262147.
KOi K01779.
OMAi CNVILLG.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-661-MONOMER.

Miscellaneous databases

EvolutionaryTracei O58403.

Family and domain databases

Gene3Di 3.40.50.1860. 2 hits.
InterProi IPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS.
IPR004380. Asp_race.
[Graphical view ]
Pfami PF01177. Asp_Glu_race. 1 hit.
[Graphical view ]
SUPFAMi SSF53681. SSF53681. 2 hits.
TIGRFAMsi TIGR00035. asp_race. 1 hit.
PROSITEi PS00923. ASP_GLU_RACEMASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3Imported.
  2. "Structural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemases."
    Liu L., Iwata K., Yohda M., Miki K.
    FEBS Lett. 528:114-118(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 103-213.
  3. "Crystal structure of aspartate racemase from Pyrococcus horikoshii OT3 and its implications for molecular mechanism of PLP-independent racemization."
    Liu L., Iwata K., Kita A., Kawarabayasi Y., Yohda M., Miki K.
    J. Mol. Biol. 319:479-489(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS), ACTIVE SITE.
  4. "Structure of aspartate racemase complexed with a dual substrate analogue, citric acid, and implications for the reaction mechanism."
    Ohtaki A., Nakano Y., Iizuka R., Arakawa T., Yamada K., Odaka M., Yohda M.
    Proteins 70:1167-1174(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS), ACTIVE SITE.

Entry informationi

Entry nameiO58403_PYRHO
AccessioniPrimary (citable) accession number: O58403
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3