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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-647-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:PH0665
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492071 – 249DNA polymerase sliding clampAdd BLAST249

Proteomic databases

PRIDEiO58398

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0665

Structurei

3D structure databases

ProteinModelPortaliO58398
SMRiO58398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiSDGFDKY
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

O58398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFEIVFEGA KEFAQLIETA SRLIDEAAFK VTEEGISMRA MDPSRVVLID
60 70 80 90 100
LNLPSSIFSK YEVDGEETIG VNMDHLKKVL KRGKAKDTLI LRKGEENFLE
110 120 130 140 150
ISLQGTATRT FRLPLIDVEE IEVELPDLPY TAKVVVLGEV LKEAVKDASL
160 170 180 190 200
VSDSIKFMAK ENEFIMRAEG ETQEVEVKLT LEDEGLLDIE VQEETKSAYG
210 220 230 240
VSYLADMVKG IGKADEVTMR FGNEMPMQME YYIRDEGRLT FLLAPRVEE
Length:249
Mass (Da):28,097
Last modified:August 1, 1998 - v1
Checksum:i70188E05034620D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29756.1
PIRiB71112
RefSeqiWP_010884759.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29756; BAA29756; BAA29756
GeneIDi1442994
KEGGipho:PH0665

Similar proteinsi

Entry informationi

Entry nameiPCNA_PYRHO
AccessioniPrimary (citable) accession number: O58398
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health