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Protein

Endonuclease V

Gene

nfi

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi31MagnesiumUniRule annotation1
Metal bindingi95MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-643-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:PH0661
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596921 – 211Endonuclease VAdd BLAST211

Proteomic databases

PRIDEiO58394

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei67Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi70601.PH0661

Structurei

3D structure databases

ProteinModelPortaliO58394
SMRiO58394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00929 Archaea
COG1515 LUCA
HOGENOMiHOG000229135
KOiK05982
OMAiVKVGKYY
OrthoDBiPOG093Z0CUB

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 2 hits
PfamiView protein in Pfam
PF04493 Endonuclease_5, 2 hits

Sequencei

Sequence statusi: Complete.

O58394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERIANIQK KLSKSIVERK INEVRKVAAV DVSYKEEKAR AALVITTFPE
60 70 80 90 100
GEVLKTKVIE TTVSFPYIPT FFFLRETKPI LIATKGETFD VLIVEGHGKA
110 120 130 140 150
HPRGYGLASH IGVVLRKPTI GVAKRLLKNT PKDTYKKVGK VYVSVGNLIT
160 170 180 190 200
LEDATKIIRA ILDESGYPKP LKLADKLSKG RIYEVKNTPS PNRSRKKRGN
210
RGKDNNNSQG N
Length:211
Mass (Da):23,540
Last modified:August 1, 1998 - v1
Checksum:i552B8BDCB488A81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29752.1
PIRiF71111
RefSeqiWP_010884755.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29752; BAA29752; BAA29752
GeneIDi1442990
KEGGipho:PH0661

Similar proteinsi

Entry informationi

Entry nameiNFI_PYRHO
AccessioniPrimary (citable) accession number: O58394
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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