Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29ZincBy similarity1
Metal bindingi209ZincBy similarity1
Metal bindingi234ZincBy similarity1
Metal bindingi238ZincBy similarity1
Binding sitei269ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-623-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:PH0636
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595431 – 476Cysteine--tRNA ligaseAdd BLAST476

Proteomic databases

PRIDEiO58370

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0636

Structurei

3D structure databases

ProteinModelPortaliO58370
SMRiO58370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 41"HIGH" regionAdd BLAST11
Motifi266 – 270"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00486 Archaea
COG0215 LUCA
HOGENOMiHOG000245250
KOiK01883
OMAiHECEIAQ
OrthoDBiPOG093Z01UF

Family and domain databases

CDDicd00672 CysRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00041 Cys_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR015803 Cys-tRNA-ligase
IPR015273 Cys-tRNA-synt_Ia_DALR
IPR024909 Cys-tRNA/MSH_ligase
IPR014729 Rossmann-like_a/b/a_fold
IPR032678 tRNA-synt_1_cat_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR10890 PTHR10890, 1 hit
PfamiView protein in Pfam
PF09190 DALR_2, 1 hit
PF01406 tRNA-synt_1e, 1 hit
PRINTSiPR00983 TRNASYNTHCYS
SMARTiView protein in SMART
SM00840 DALR_2, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
TIGRFAMsiTIGR00435 cysS, 1 hit

Sequencei

Sequence statusi: Complete.

O58370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRIYNTLT KQKEEFKPIN EGEVRMYVCG PTVYDYPHLG HARTYIAFDV
60 70 80 90 100
IRRYLEHKGY SVLMVMNFTD IDDKIIRRAK ETGEDPAKLA EKFIKVFLED
110 120 130 140 150
MKALKVKPAD IYPRVTEHIE DIIQFIERLK EKGYAYEGSD GVYFEVQKFK
160 170 180 190 200
EYGKLSGVKL EELRKGARVE PGEGKKNPED FALWKKAKPG EPKWESPWGE
210 220 230 240 250
GRPGWHIECS VMSSKYLGES FDIHGGGNDL IFPHHENEIA QSEACFGHEW
260 270 280 290 300
VHYWLHTGFV MVKGEKMSKS LGNFVTVREL LQRYSPEVIR FFVLQKHYRS
310 320 330 340 350
PLDYSEEGLQ HAKNNLERLY NTLENIRIAM ENAELAYTWD ENDFKAYNSI
360 370 380 390 400
KEARRKFYEA MDDDFNTAEA LKAVFEVSNA INKYITEAEK PKESVLRKAW
410 420 430 440 450
EFFRTVGEIF GIFEEYFKEE KAKEEEKLIE LLIQVRAELR KERKFELADK
460 470
IREELRKLGI QLEDKGKETI WKRIKV
Length:476
Mass (Da):56,044
Last modified:August 1, 1998 - v1
Checksum:i0AC0289CBC5ED450
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29726.1
PIRiD71108
RefSeqiWP_010884735.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29726; BAA29726; BAA29726
GeneIDi1442970
KEGGipho:PH0636

Similar proteinsi

Entry informationi

Entry nameiSYC_PYRHO
AccessioniPrimary (citable) accession number: O58370
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health