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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76By similarity1
Active sitei139By similarity1
Active sitei163By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.19.3 5244

Protein family/group databases

MEROPSiC15.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:PH0596
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847561 – 206Pyrrolidone-carboxylate peptidaseAdd BLAST206

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

MINTiO58321
STRINGi70601.PH0596

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi18 – 29Combined sources12
Beta strandi33 – 38Combined sources6
Helixi42 – 56Combined sources15
Beta strandi59 – 66Combined sources8
Beta strandi71 – 76Combined sources6
Beta strandi78 – 81Combined sources4
Beta strandi96 – 98Combined sources3
Beta strandi106 – 109Combined sources4
Helixi114 – 123Combined sources10
Beta strandi128 – 132Combined sources5
Helixi138 – 153Combined sources16
Beta strandi156 – 164Combined sources9
Helixi168 – 170Combined sources3
Helixi182 – 202Combined sources21
Turni203 – 205Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IU8X-ray1.60A/B1-206[»]
ProteinModelPortaliO58321
SMRiO58321
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58321

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

eggNOGiarCOG05850 Archaea
COG2039 LUCA
HOGENOMiHOG000242641
KOiK01304
OMAiVCNHVFY
OrthoDBiPOG093Z0BJN

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
TIGRFAMsiTIGR00504 pyro_pdase, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

O58321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLTGFEP FGGDDKNPTM DIVEALSERI PEVVGEILPV SFKRAREKLL
60 70 80 90 100
KVLDDVRPDI TINLGLAPGR THISVERVAV NMIDARIPDN DGEQPKDEPI
110 120 130 140 150
VEGGPAAYFA TIPTREIVEE MKKNGIPAVL SYTAGTYLCN FAMYLTLHTS
160 170 180 190 200
ATKGYPKIAG FIHVPYTPDQ VLEKKNTPSM SLDLEIKGVE IAIRVAQSAL

HSSQLR
Length:206
Mass (Da):22,640
Last modified:August 1, 1998 - v1
Checksum:iCA16F1009BDB1766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29685.1
PIRiH71174

Genome annotation databases

EnsemblBacteriaiBAA29685; BAA29685; BAA29685
KEGGipho:PH0596

Similar proteinsi

Entry informationi

Entry nameiPCP_PYRHO
AccessioniPrimary (citable) accession number: O58321
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health