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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76By similarity1
Active sitei139By similarity1
Active sitei163By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.19.3. 5244.

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:PH0596
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847561 – 206Pyrrolidone-carboxylate peptidaseAdd BLAST206

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

MINTiMINT-1500810.
STRINGi70601.PH0596.

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi18 – 29Combined sources12
Beta strandi33 – 38Combined sources6
Helixi42 – 56Combined sources15
Beta strandi59 – 66Combined sources8
Beta strandi71 – 76Combined sources6
Beta strandi78 – 81Combined sources4
Beta strandi96 – 98Combined sources3
Beta strandi106 – 109Combined sources4
Helixi114 – 123Combined sources10
Beta strandi128 – 132Combined sources5
Helixi138 – 153Combined sources16
Beta strandi156 – 164Combined sources9
Helixi168 – 170Combined sources3
Helixi182 – 202Combined sources21
Turni203 – 205Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IU8X-ray1.60A/B1-206[»]
ProteinModelPortaliO58321.
SMRiO58321.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58321.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

eggNOGiarCOG05850. Archaea.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLTGFEP FGGDDKNPTM DIVEALSERI PEVVGEILPV SFKRAREKLL
60 70 80 90 100
KVLDDVRPDI TINLGLAPGR THISVERVAV NMIDARIPDN DGEQPKDEPI
110 120 130 140 150
VEGGPAAYFA TIPTREIVEE MKKNGIPAVL SYTAGTYLCN FAMYLTLHTS
160 170 180 190 200
ATKGYPKIAG FIHVPYTPDQ VLEKKNTPSM SLDLEIKGVE IAIRVAQSAL

HSSQLR
Length:206
Mass (Da):22,640
Last modified:August 1, 1998 - v1
Checksum:iCA16F1009BDB1766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29685.1.
PIRiH71174.
RefSeqiWP_010884697.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29685; BAA29685; BAA29685.
GeneIDi1442931.
KEGGipho:PH0596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29685.1.
PIRiH71174.
RefSeqiWP_010884697.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IU8X-ray1.60A/B1-206[»]
ProteinModelPortaliO58321.
SMRiO58321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1500810.
STRINGi70601.PH0596.

Protein family/group databases

MEROPSiC15.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29685; BAA29685; BAA29685.
GeneIDi1442931.
KEGGipho:PH0596.

Phylogenomic databases

eggNOGiarCOG05850. Archaea.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.

Enzyme and pathway databases

BRENDAi3.4.19.3. 5244.

Miscellaneous databases

EvolutionaryTraceiO58321.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCP_PYRHO
AccessioniPrimary (citable) accession number: O58321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.