Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761By similarity
Active sitei139 – 1391By similarity
Active sitei163 – 1631By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-592-MONOMER.
BRENDAi3.4.19.3. 5244.

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:PH0596
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Pyrrolidone-carboxylate peptidasePRO_0000184756Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

MINTiMINT-1500810.
STRINGi70601.PH0596.

Structurei

Secondary structure

1
206
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi18 – 2912Combined sources
Beta strandi33 – 386Combined sources
Helixi42 – 5615Combined sources
Beta strandi59 – 668Combined sources
Beta strandi71 – 766Combined sources
Beta strandi78 – 814Combined sources
Beta strandi96 – 983Combined sources
Beta strandi106 – 1094Combined sources
Helixi114 – 12310Combined sources
Beta strandi128 – 1325Combined sources
Helixi138 – 15316Combined sources
Beta strandi156 – 1649Combined sources
Helixi168 – 1703Combined sources
Helixi182 – 20221Combined sources
Turni203 – 2053Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IU8X-ray1.60A/B1-206[»]
ProteinModelPortaliO58321.
SMRiO58321. Positions 1-206.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58321.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

eggNOGiarCOG05850. Archaea.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLTGFEP FGGDDKNPTM DIVEALSERI PEVVGEILPV SFKRAREKLL
60 70 80 90 100
KVLDDVRPDI TINLGLAPGR THISVERVAV NMIDARIPDN DGEQPKDEPI
110 120 130 140 150
VEGGPAAYFA TIPTREIVEE MKKNGIPAVL SYTAGTYLCN FAMYLTLHTS
160 170 180 190 200
ATKGYPKIAG FIHVPYTPDQ VLEKKNTPSM SLDLEIKGVE IAIRVAQSAL

HSSQLR
Length:206
Mass (Da):22,640
Last modified:August 1, 1998 - v1
Checksum:iCA16F1009BDB1766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29685.1.
PIRiH71174.
RefSeqiWP_010884697.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29685; BAA29685; BAA29685.
GeneIDi1442931.
KEGGipho:PH0596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29685.1.
PIRiH71174.
RefSeqiWP_010884697.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IU8X-ray1.60A/B1-206[»]
ProteinModelPortaliO58321.
SMRiO58321. Positions 1-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1500810.
STRINGi70601.PH0596.

Protein family/group databases

MEROPSiC15.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29685; BAA29685; BAA29685.
GeneIDi1442931.
KEGGipho:PH0596.

Phylogenomic databases

eggNOGiarCOG05850. Archaea.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-592-MONOMER.
BRENDAi3.4.19.3. 5244.

Miscellaneous databases

EvolutionaryTraceiO58321.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCP_PYRHO
AccessioniPrimary (citable) accession number: O58321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.