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Protein

Glyoxylate reductase

Gene

gyaR

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241By similarity1
Active sitei270By similarity1
Active sitei288Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADP1 Publication4
Nucleotide bindingi180 – 182NADP1 Publication3
Nucleotide bindingi239 – 241NADP1 Publication3
Nucleotide bindingi288 – 290NADP1 Publication3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-586-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase (EC:1.1.1.26)
Gene namesi
Name:gyaR
Ordered Locus Names:PH0597
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759491 – 334Glyoxylate reductaseAdd BLAST334

Proteomic databases

PRIDEiO58320

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0597

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi13 – 20Combined sources8
Beta strandi23 – 27Combined sources5
Beta strandi30 – 32Combined sources3
Helixi36 – 42Combined sources7
Turni43 – 45Combined sources3
Beta strandi47 – 51Combined sources5
Helixi59 – 63Combined sources5
Beta strandi70 – 76Combined sources7
Helixi83 – 88Combined sources6
Beta strandi92 – 94Combined sources3
Beta strandi98 – 100Combined sources3
Helixi101 – 117Combined sources17
Helixi119 – 127Combined sources9
Helixi130 – 133Combined sources4
Turni140 – 143Combined sources4
Beta strandi152 – 156Combined sources5
Helixi160 – 171Combined sources12
Beta strandi175 – 179Combined sources5
Beta strandi181 – 184Combined sources4
Helixi185 – 191Combined sources7
Beta strandi193 – 195Combined sources3
Helixi198 – 204Combined sources7
Beta strandi206 – 210Combined sources5
Turni216 – 220Combined sources5
Helixi224 – 229Combined sources6
Beta strandi235 – 238Combined sources4
Helixi242 – 244Combined sources3
Helixi247 – 255Combined sources9
Beta strandi258 – 265Combined sources8
Beta strandi268 – 271Combined sources4
Helixi275 – 279Combined sources5
Beta strandi283 – 285Combined sources3
Helixi294 – 312Combined sources19
Helixi325 – 328Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBQX-ray1.70A1-334[»]
2DBRX-ray2.61A/B/C/D/E/F1-334[»]
2DBZX-ray2.45A/B1-334[»]
ProteinModelPortaliO58320
SMRiO58320
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58320

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01755 Archaea
COG1052 LUCA
HOGENOMiHOG000136700
KOiK00015
OMAiKWIAHNG
OrthoDBiPOG093Z0DW1

Family and domain databases

HAMAPiMF_00776 GyaR, 1 hit
InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR023519 Glyoxylate_reductase_GyaR
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

O58320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKVFITRE IPEVGIKMLE DEFEVEVWGD EKEIPREILL KKVKEVDALV
60 70 80 90 100
TMLSERIDKE VFENAPKLRI VANYAVGYDN IDIEEATKRG IYVTNTPDVL
110 120 130 140 150
TDATADLAFA LLLATARHVV KGDRFVRSGE WKKRGVAWHP KWFLGYDVYG
160 170 180 190 200
KTIGIIGLGR IGQAIAKRAK GFNMRILYYS RTRKEEVERE LNAEFKPLED
210 220 230 240 250
LLRESDFVVL AVPLTRETYH LINEERLKLM KKTAILINIA RGKVVDTNAL
260 270 280 290 300
VKALKEGWIA GAGLDVFEEE PYYNEELFKL DNVVLTPHIG SASFGAREGM
310 320 330
AELVAKNLIA FKRGEIPPTL VNREVIKIRK PGFE
Length:334
Mass (Da):38,000
Last modified:May 10, 2004 - v2
Checksum:iC0056A354ECBE202
GO

Sequence cautioni

The sequence BAA29686 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29686.1 Different initiation.
PIRiA71175
RefSeqiWP_010884698.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29686; BAA29686; BAA29686
GeneIDi1442932
KEGGipho:PH0597

Similar proteinsi

Entry informationi

Entry nameiGYAR_PYRHO
AccessioniPrimary (citable) accession number: O58320
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 25, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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