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Protein

Glyoxylate reductase

Gene

gyaR

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241By similarity1
Active sitei270By similarity1
Active sitei288Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADP1 Publication4
Nucleotide bindingi180 – 182NADP1 Publication3
Nucleotide bindingi239 – 241NADP1 Publication3
Nucleotide bindingi288 – 290NADP1 Publication3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase (EC:1.1.1.26)
Gene namesi
Name:gyaR
Ordered Locus Names:PH0597
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759491 – 334Glyoxylate reductaseAdd BLAST334

Proteomic databases

PRIDEiO58320.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0597.

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi13 – 20Combined sources8
Beta strandi23 – 27Combined sources5
Beta strandi30 – 32Combined sources3
Helixi36 – 42Combined sources7
Turni43 – 45Combined sources3
Beta strandi47 – 51Combined sources5
Helixi59 – 63Combined sources5
Beta strandi70 – 76Combined sources7
Helixi83 – 88Combined sources6
Beta strandi92 – 94Combined sources3
Beta strandi98 – 100Combined sources3
Helixi101 – 117Combined sources17
Helixi119 – 127Combined sources9
Helixi130 – 133Combined sources4
Turni140 – 143Combined sources4
Beta strandi152 – 156Combined sources5
Helixi160 – 171Combined sources12
Beta strandi175 – 179Combined sources5
Beta strandi181 – 184Combined sources4
Helixi185 – 191Combined sources7
Beta strandi193 – 195Combined sources3
Helixi198 – 204Combined sources7
Beta strandi206 – 210Combined sources5
Turni216 – 220Combined sources5
Helixi224 – 229Combined sources6
Beta strandi235 – 238Combined sources4
Helixi242 – 244Combined sources3
Helixi247 – 255Combined sources9
Beta strandi258 – 265Combined sources8
Beta strandi268 – 271Combined sources4
Helixi275 – 279Combined sources5
Beta strandi283 – 285Combined sources3
Helixi294 – 312Combined sources19
Helixi325 – 328Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBQX-ray1.70A1-334[»]
2DBRX-ray2.61A/B/C/D/E/F1-334[»]
2DBZX-ray2.45A/B1-334[»]
ProteinModelPortaliO58320.
SMRiO58320.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58320.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
KOiK00015.
OMAiKSIGPDW.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O58320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKVFITRE IPEVGIKMLE DEFEVEVWGD EKEIPREILL KKVKEVDALV
60 70 80 90 100
TMLSERIDKE VFENAPKLRI VANYAVGYDN IDIEEATKRG IYVTNTPDVL
110 120 130 140 150
TDATADLAFA LLLATARHVV KGDRFVRSGE WKKRGVAWHP KWFLGYDVYG
160 170 180 190 200
KTIGIIGLGR IGQAIAKRAK GFNMRILYYS RTRKEEVERE LNAEFKPLED
210 220 230 240 250
LLRESDFVVL AVPLTRETYH LINEERLKLM KKTAILINIA RGKVVDTNAL
260 270 280 290 300
VKALKEGWIA GAGLDVFEEE PYYNEELFKL DNVVLTPHIG SASFGAREGM
310 320 330
AELVAKNLIA FKRGEIPPTL VNREVIKIRK PGFE
Length:334
Mass (Da):38,000
Last modified:May 10, 2004 - v2
Checksum:iC0056A354ECBE202
GO

Sequence cautioni

The sequence BAA29686 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29686.1. Different initiation.
PIRiA71175.
RefSeqiWP_010884698.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29686; BAA29686; BAA29686.
GeneIDi1442932.
KEGGipho:PH0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29686.1. Different initiation.
PIRiA71175.
RefSeqiWP_010884698.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBQX-ray1.70A1-334[»]
2DBRX-ray2.61A/B/C/D/E/F1-334[»]
2DBZX-ray2.45A/B1-334[»]
ProteinModelPortaliO58320.
SMRiO58320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0597.

Proteomic databases

PRIDEiO58320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29686; BAA29686; BAA29686.
GeneIDi1442932.
KEGGipho:PH0597.

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
KOiK00015.
OMAiKSIGPDW.

Miscellaneous databases

EvolutionaryTraceiO58320.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGYAR_PYRHO
AccessioniPrimary (citable) accession number: O58320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.