ID   NIKR_PYRHO              Reviewed;         138 AA.
AC   O58316;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-NOV-2009, entry version 58.
DE   RecName: Full=Putative nickel-responsive regulator;
GN   OrderedLocusNames=PH0601;
OS   Pyrococcus horikoshii.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=53953;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT3;
RX   MEDLINE=98344137; PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y.,
RA   Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y.,
RA   Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K.,
RA   Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Transcriptional regulator (Potential).
CC   -!- COFACTOR: Binds 1 nickel ion per subunit (By similarity).
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory copG/nikR
CC       family.
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DR   EMBL; BA000001; BAA29690.1; -; Genomic_DNA.
DR   PIR; E71175; E71175.
DR   RefSeq; NP_142565.1; -.
DR   PDB; 2BJ1; X-ray; 3.00 A; A/B=1-138.
DR   PDB; 2BJ3; X-ray; 2.20 A; A/B/C/D=1-138.
DR   PDB; 2BJ7; X-ray; 2.10 A; A/B=1-138.
DR   PDB; 2BJ8; X-ray; 2.10 A; A/B=1-138.
DR   PDB; 2BJ9; X-ray; 3.00 A; A/B=1-138.
DR   PDBsum; 2BJ1; -.
DR   PDBsum; 2BJ3; -.
DR   PDBsum; 2BJ7; -.
DR   PDBsum; 2BJ8; -.
DR   PDBsum; 2BJ9; -.
DR   GeneID; 1442936; -.
DR   GenomeReviews; BA000001_GR; PH0601.
DR   KEGG; pho:PH0601; -.
DR   NMPDR; fig|70601.1.peg.589; -.
DR   HOGENOM; O58316; -.
DR   OMA; DEHNCLE; -.
DR   GO; GO:0016151; F:nickel ion binding; IEA:HAMAP.
DR   GO; GO:0003700; F:transcription factor activity; IEA:HAMAP.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:HAMAP.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   HAMAP; MF_00476; -; 1.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG_DNA_bd.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Gene3D; G3DSA:1.10.1220.10; Arc_rbn_hlx_hlx; 1.
DR   Gene3D; G3DSA:3.30.70.1150; NikR_bd_C; 1.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; DNA-binding; Metal-binding; Nickel;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    138       Putative nickel-responsive regulator.
FT                                /FTId=PRO_0000139312.
FT   METAL        78     78       Nickel (By similarity).
FT   METAL        89     89       Nickel (By similarity).
FT   METAL        91     91       Nickel (By similarity).
FT   METAL        97     97       Nickel (By similarity).
FT   STRAND        3     11
FT   HELIX        12     25
FT   HELIX        30     45
FT   HELIX        46     48
FT   STRAND       53     63
FT   HELIX        69     79
FT   TURN         80     83
FT   STRAND       84     91
FT   STRAND       93    106
FT   HELIX       107    119
FT   STRAND      123    133
SQ   SEQUENCE   138 AA;  15806 MW;  A4B8715636C019FE CRC64;
     MELIRFSISI PSKLLEKFDQ IIEEIGYENR SEAIRDLIRD FIIRHEWEVG NEEVAGTITI
     VYNHDEGDVV KALLDLQHEY LDEIISSLHV HMDEHNCLEV IVVKGEAKKI KMIADKLLSL
     KGVKHGKLVM TSTGKELV
//