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Protein

Putative nickel-responsive regulator

Gene

PH0601

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator.UniRule annotation

Cofactori

Ni2+UniRule annotationNote: Binds 1 nickel ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781NickelUniRule annotation
Metal bindingi89 – 891NickelUniRule annotation
Metal bindingi91 – 911NickelUniRule annotation
Metal bindingi97 – 971NickelUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-597-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nickel-responsive regulatorUniRule annotation
Gene namesi
Ordered Locus Names:PH0601
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Putative nickel-responsive regulatorPRO_0000139312Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0601.

Structurei

Secondary structure

1
138
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 119Combined sources
Helixi12 – 2514Combined sources
Helixi30 – 4415Combined sources
Helixi46 – 483Combined sources
Beta strandi51 – 6313Combined sources
Helixi69 – 7911Combined sources
Turni80 – 834Combined sources
Beta strandi84 – 918Combined sources
Beta strandi93 – 10614Combined sources
Helixi107 – 11812Combined sources
Beta strandi123 – 1319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BJ1X-ray3.00A/B1-138[»]
2BJ3X-ray2.20A/B/C/D1-138[»]
2BJ7X-ray2.10A/B1-138[»]
2BJ8X-ray2.10A/B1-138[»]
2BJ9X-ray3.00A/B1-138[»]
ProteinModelPortaliO58316.
SMRiO58316. Positions 1-138.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58316.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcriptional regulatory CopG/NikR family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01008. Archaea.
COG0864. LUCA.
HOGENOMiHOG000102781.
KOiK07722.
OMAiITIVYNH.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR. 1 hit.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.

Sequencei

Sequence statusi: Complete.

O58316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIRFSISI PSKLLEKFDQ IIEEIGYENR SEAIRDLIRD FIIRHEWEVG
60 70 80 90 100
NEEVAGTITI VYNHDEGDVV KALLDLQHEY LDEIISSLHV HMDEHNCLEV
110 120 130
IVVKGEAKKI KMIADKLLSL KGVKHGKLVM TSTGKELV
Length:138
Mass (Da):15,806
Last modified:August 1, 1998 - v1
Checksum:iA4B8715636C019FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29690.1.
PIRiE71175.
RefSeqiWP_010884702.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29690; BAA29690; BAA29690.
GeneIDi1442936.
KEGGipho:PH0601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29690.1.
PIRiE71175.
RefSeqiWP_010884702.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BJ1X-ray3.00A/B1-138[»]
2BJ3X-ray2.20A/B/C/D1-138[»]
2BJ7X-ray2.10A/B1-138[»]
2BJ8X-ray2.10A/B1-138[»]
2BJ9X-ray3.00A/B1-138[»]
ProteinModelPortaliO58316.
SMRiO58316. Positions 1-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29690; BAA29690; BAA29690.
GeneIDi1442936.
KEGGipho:PH0601.

Phylogenomic databases

eggNOGiarCOG01008. Archaea.
COG0864. LUCA.
HOGENOMiHOG000102781.
KOiK07722.
OMAiITIVYNH.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-597-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO58316.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
HAMAPiMF_00476. NikR. 1 hit.
InterProiIPR013321. Arc_rbn_hlx_hlx.
IPR002145. CopG.
IPR022988. Ni_resp_reg_NikR.
IPR010985. Ribbon_hlx_hlx.
IPR014864. TF_NikR_Ni-bd_C.
[Graphical view]
PfamiPF08753. NikR_C. 1 hit.
PF01402. RHH_1. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIKR_PYRHO
AccessioniPrimary (citable) accession number: O58316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.