Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei188NADUniRule annotation1
Binding sitei240NADUniRule annotation1
Binding sitei343NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 156NADUniRule annotation3
Nucleotide bindingi217 – 222NADUniRule annotation6
Nucleotide bindingi296 – 298NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:PH0540
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

O58275:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170121 – 421AdenosylhomocysteinaseAdd BLAST421

Interactioni

Protein-protein interaction databases

MINTiMINT-1502222.
STRINGi70601.PH0540.

Structurei

3D structure databases

ProteinModelPortaliO58275.
SMRiO58275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137. Archaea.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG093Z03XF.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O58275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCGRDYCVK DLSLADEGWK KIDWVSRFMP VLQHIRREFE EKKPFKGVRI
60 70 80 90 100
AATLHLEMKT AFLLLTLKAG GAEVSAAASN PLSTQDDVVA ALAKAGVKVY
110 120 130 140 150
AIRGESKEQY YEFMHKALDI RPNIIIDDGA DMISLVHKER QELLDEIWGG
160 170 180 190 200
SEETTTGVIR LRAMERDGVL RFSVIAVNDS YMKYLFDNRY GTGQSTWDGV
210 220 230 240 250
MRATNLLIAG KNVVVVGYGW CGRGIAMRAR GLGATVIVVE VDPIKALEAR
260 270 280 290 300
MDGFLVMNMK EAAKIGDIFI TATGDIKCIR REHFELMKDG AIMANAGHFD
310 320 330 340 350
VEIWKPDLEE LAVEISNPRP NVTEYKLKDG RRLYLLADGR LVNLVAADGH
360 370 380 390 400
PAEIMDMSFA LQAKAAEYIK DNHGKLEPRV YILPREIDEM VARIKLASMG
410 420
IEIEELTEEQ KKYLESWEHG T
Length:421
Mass (Da):47,274
Last modified:December 15, 1998 - v2
Checksum:i6BEE049F5E5D951E
GO

Sequence cautioni

O58275: The sequence BAA29629 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29629.1. Different initiation.
PIRiH71167.
RefSeqiWP_048053154.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29629; BAA29629; BAA29629.
GeneIDi1444429.
KEGGipho:PH0540.

Similar proteinsi

Entry informationi

Entry nameiSAHH_PYRHO
AccessioniPrimary (citable) accession number: O58275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 25, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families