ID   O58227_PYRHO            Unreviewed;       739 AA.
AC   O58227;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=739aa long hypothetical chemotaxis protein {ECO:0000313|EMBL:BAA29579.1};
GN   OrderedLocusNames=PH0491 {ECO:0000313|EMBL:BAA29579.1};
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA29579.1, ECO:0000313|Proteomes:UP000000752};
RN   [1] {ECO:0000313|EMBL:BAA29579.1, ECO:0000313|Proteomes:UP000000752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
RC   {ECO:0000313|Proteomes:UP000000752};
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y.,
RA   Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; BA000001; BAA29579.1; -; Genomic_DNA.
DR   PIR; F71161; F71161.
DR   RefSeq; WP_010884598.1; NC_000961.1.
DR   AlphaFoldDB; O58227; -.
DR   STRING; 70601.gene:9377425; -.
DR   EnsemblBacteria; BAA29579; BAA29579; BAA29579.
DR   GeneID; 1444385; -.
DR   KEGG; pho:PH0491; -.
DR   eggNOG; arCOG02320; Archaea.
DR   eggNOG; arCOG02362; Archaea.
DR   OrthoDB; 342253at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   CDD; cd12913; PDC1_MCP_like; 1.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 3.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 2.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          382..434
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          453..710
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   COILED          450..481
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          597..733
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   739 AA;  81992 MW;  B18376DCD5F7D535 CRC64;
     MQFKKKIILI MILAAVVSTA ILGGVTLYSF SKVDTMMREE LEKPAIEEGG YMALSAADLA
     TRMFEDFFAR VSDYGKMAND AVQEAYSRGL DLNEDMMRQF LLERFKKIKD LNEDVSYVYF
     GDEQGHMYMY PPDELPEGYD PRVRPWYKLA KEKNGPVITE PYRDAATGKW VITYSEPVYV
     NGEFKGVIGI DVFVSTLVKE TQSIKLGKTG YVAVLNPQGL VIIHPKEEYI NKLNIFQTPE
     LKDLANELRK GKERGYVVYT FEGIKKVAGY RRMKQTGWIV LATVPLEEIT EPTLKAADSV
     VKDVSEMIYK GFGIAIIAIV AMIVAMYKVA GSILAPLEKL KMAAQALANG KLREVTEYVK
     EIRYLENDEI GALIQAFEAV SKDLVGTLTA ITKRLERLAE GDLTNGLTVE AKGELRDLIE
     DIKSVTNTLR TSIGSLVDMA NELEKRANAL AQISNDVTEA INQVNEAIQQ VSVEAQRQQE
     TINEITEGMR LVAQTSEESV KAMEEFEGAV SEVVSIANEG SQKGDDALKR IEDIQHMMSR
     IEETVSKVSE MSRNIEEITN VITSIAEQTN LLALNAAIEA ARAGEAGRGF AVVAQEIRKL
     AEESKQAADN IKSIIDKITD EIKEAVEATK EGVNVIGQSS ETLRDTIGYL ANIATLLQET
     SERMSEVKDQ IVKTQEEVDK SLRALENLAA SAEETTASAE EVSSAVEEQT ASIEELRRAA
     QELRDIVEKM RGIIAKFKV
//