Reviewed,
UniProtKB/Swiss-Prot O58221 (LONH_PYRHO)
Last modified
December 15, 2009.
Version 68.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative protease La homolog EC=3.4.21.- Cleaved into the following chain: 1- Recommended name: Pho lon intein | ||
| Gene names |
| ||
| Organism | Pyrococcus horikoshii [Complete proteome] [HAMAP] | ||
| Taxonomic identifier | 53953 [NCBI] | ||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 1127 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Post-translational modification | This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential. |
| Sequence similarities | Belongs to the peptidase S16 family. Contains 1 DOD-type homing endonuclease domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 210 | 210 | Putative protease La homolog, 1st part Potential | PRO_0000026729 | |||||
| Chain | 211 – 684 | 474 | Pho lon intein Potential | PRO_0000026730 | |||||
| Chain | 685 – 1127 | 443 | Putative protease La homolog, 2nd part Potential | PRO_0000026731 | |||||
Regions | |||||||||
| Domain | 417 – 572 | 156 | DOD-type homing endonuclease | ||||||
| Nucleotide binding | 59 – 66 | 8 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 990 | 1 | By similarity | ||||||
| Active site | 1033 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. Kikuchi H.DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3. |
Cross-references
Sequence databases | |
|---|---|
| BA000001 Genomic DNA. Translation: BAA29538.1. | |
| PIR | E71156. |
| RefSeq | NP_142432.1. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S16.005. |
Genome annotation databases | |
| GeneID | 1444348. |
| GenomeReviews | Gene locus PH0452 in contig BA000001_GR. |
| KEGG | pho:PH0452. |
| NMPDR | fig|70601.1.peg.448. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG194441. |
| OMA | ELSSGAM. |
Enzyme and pathway databases | |
| BioCyc | PHOR70601:PH0452-MON. |
Family and domain databases | |
| InterPro | IPR011704. ATPase_AAA-5. IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splicing_site. IPR004663. Pept_S16_Archaea. IPR008269. Pept_S16_C. IPR001984. Peptidase_S16_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR002078. RNA_pol_sigma_54_int. [Graphical view] |
| Pfam | PF07728. AAA_5. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view] |
| PRINTS | PR00830. ENDOLAPTASE. PR00379. INTEIN. |
| SMART | SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] |
| PROSITE | PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. PS01046. LON_SER. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LONH_PYRHO | ||||||||
| Accession | Primary (citable) accession number: O58221 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


