Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metal-dependent carboxypeptidase

Gene

PH0465

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.UniRule annotation

Catalytic activityi

Release of a C-terminal amino acid with broad specificity, except for -Pro.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi285Zinc; catalyticUniRule annotation1
Metal bindingi289Zinc; catalyticUniRule annotation1
Metal bindingi315Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotationImported, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM32.002

Names & Taxonomyi

Protein namesi
Recommended name:
Metal-dependent carboxypeptidaseUniRule annotation (EC:3.4.17.19UniRule annotation)
Gene namesi
Ordered Locus Names:PH0465Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0465

Structurei

3D structure databases

ProteinModelPortaliO58210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M32 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04247 Archaea
COG2317 LUCA
HOGENOMiHOG000040803
KOiK01299
OMAiEFGHALY
OrthoDBiPOG093Z01FT

Family and domain databases

CDDicd06460 M32_Taq, 1 hit
InterProiView protein in InterPro
IPR001333 Peptidase_M32_Taq
PANTHERiPTHR34217 PTHR34217, 1 hit
PfamiView protein in Pfam
PF02074 Peptidase_M32, 1 hit
PIRSFiPIRSF006615 Zn_crbxpep_Taq, 1 hit
PRINTSiPR00998 CRBOXYPTASET

Sequencei

Sequence statusi: Complete.

O58210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVLRRLHL EKSGETMEEV FRNDTIKEIL QKYRRIWALG HAQSVLGWDL
60 70 80 90 100
EVNMPKEGIL ERSVAQGELS VLSQELLLKP EFVELVEKAK GIEDLNEYER
110 120 130 140 150
GVVRVLDRQI RIMKSFPPEF LKEVSETTSK ATKAWEEAKA KDDFSKFEPW
160 170 180 190 200
LDKIISLAKR AAEYLGYEEE PYDALLDLYE EGLRTRDVVK MFDVLEKELR
210 220 230 240 250
PLLEKILEED KVPREHPLEK EKYEREWMEK VNLWVLEKFG YPLGTRARLD
260 270 280 290 300
VSAHPFTTEF GIRDVRITTR YEGFDFRRAL LSTIHEFGHA LYELQQDERF
310 320 330 340 350
MFTPIAGGVS LGIHESQSRF WENIIGRSKE FVEFIYPVLK ENLPFMEKYT
360 370 380 390 400
QEDVYLYFNM VRPDFIRTEA DVVTYNFHVL LRFKLERMMV SEDVKAKDLP
410 420 430 440 450
EMWNDEMERL LGIRPKTYRE GILQDIHWAH GSIGYFPTYS IGTILSAQLY
460 470 480 490 500
YHIKKDIPDF EEKVAKGEFE PIKSWLREKI HRWGSIYPPK ELLKKAIGED
510
VNAEYFVRWI KERYL
Length:515
Mass (Da):61,196
Last modified:August 1, 1998 - v1
Checksum:i4BDA599969DF4E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29552.1
PIRiC71158

Genome annotation databases

EnsemblBacteriaiBAA29552; BAA29552; BAA29552
KEGGipho:PH0465

Similar proteinsi

Entry informationi

Entry nameiO58210_PYRHO
AccessioniPrimary (citable) accession number: O58210
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health