ID   O58181_PYRHO            Unreviewed;       428 AA.
AC   O58181;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=428aa long hypothetical methyl-accepting chemotaxis protein {ECO:0000313|EMBL:BAA29529.1};
GN   OrderedLocusNames=PH0443 {ECO:0000313|EMBL:BAA29529.1};
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA29529.1, ECO:0000313|Proteomes:UP000000752};
RN   [1] {ECO:0000313|EMBL:BAA29529.1, ECO:0000313|Proteomes:UP000000752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
RC   {ECO:0000313|Proteomes:UP000000752};
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y.,
RA   Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000001; BAA29529.1; -; Genomic_DNA.
DR   PIR; D71155; D71155.
DR   RefSeq; WP_010884553.1; NC_000961.1.
DR   AlphaFoldDB; O58181; -.
DR   STRING; 70601.gene:9377374; -.
DR   EnsemblBacteria; BAA29529; BAA29529; BAA29529.
DR   GeneID; 1444340; -.
DR   KEGG; pho:PH0443; -.
DR   eggNOG; arCOG02320; Archaea.
DR   OrthoDB; 86140at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}.
FT   DOMAIN          60..111
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          130..387
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   COILED          127..165
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          327..410
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   428 AA;  46920 MW;  02298BC1DF9E59EA CRC64;
     MKVSVITPIL PFLFTIVPAA IDSLPGAVIG GVIGLGIASY INYRTEGKAE LPMELEEYKK
     NLEKRIEEIS VILERIAHGD LSVEDSEISG ELAKIREGIE KLRQSISGLV LNVKNAAIDV
     KNHAKVMKDN IEQIAEAVAQ VAEAINQVSA EAQREQENIS KMTETMRYIN DISKETVSTM
     EEFEASMREM AQLAKEGGEK GRMAATQIEE ISRMMQMIEE TVRGVADMGK NIENITNVIS
     SIAEQTNLLA LNAAIEAARA GEAGKGFAVV ADEIRKLAEE SKKAAEDIRE LIKQIGDKIS
     ESVEVTKQGA EVVGTSTEVI KESVNYLTQV AEMMEEMEAK ASELREKVIQ EGEKIEEGLK
     FLENLAASAE ETTAAAEEVS AAAEEQSSAL QELKESVKEL DRLVDVLMEH IGKFKLSKDH
     EAKVKEIK
//