336aa long hypothetical dTDP-glucose 4,6-dehydratase - Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

Preferred order of sections

Names and origin

Protein names

Submitted name:
336aa long hypothetical dTDP-glucose 4,6-dehydratase EMBL BAA29500.1

Gene names

Ordered Locus Names:

PH0414

Organism

Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]

Taxonomic identifier

70601 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the sugar epimerase family. RuleBase RU003508

Ontologies

Keywords
Ligand	NAD RuleBase RU003508 PDB 2HUN Nucleotide-binding PDB 2HUN
Technical term	3D-structure PDB 2HUN Complete proteome
Gene Ontology (GO)
Biological process	nucleotide-sugar metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro dTDP-glucose 4,6-dehydratase activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

13 – 15

3

NAD PDB 2HUN

Nucleotide binding

36 – 39

4

NAD PDB 2HUN

Nucleotide binding

62 – 63

2

NAD PDB 2HUN

Nucleotide binding

82 – 86

5

NAD PDB 2HUN

Sites

Binding site

101

1

NAD PDB 2HUN

Binding site

125

1

NAD; via carbonyl oxygen PDB 2HUN

Binding site

151

1

NAD PDB 2HUN

Binding site

155

1

NAD PDB 2HUN

Binding site

181

1

NAD; via amide nitrogen PDB 2HUN

Sequences

Sequence

Length

Mass (Da)

Tools

O58151 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: FEA88AD528DDBE86
Show »

FASTA

336

38,928

        10         20         30         40         50         60 
MHSMKLLVTG GMGFIGSNFI RYILEKHPDW EVINIDKLGY GSNPANLKDL EDDPRYTFVK 

        70         80         90        100        110        120 
GDVADYELVK ELVRKVDGVV HLAAESHVDR SISSPEIFLH SNVIGTYTLL ESIRRENPEV 

       130        140        150        160        170        180 
RFVHVSTDEV YGDILKGSFT ENDRLMPSSP YSATKAASDM LVLGWTRTYN LNASITRCTN 

       190        200        210        220        230        240 
NYGPYQFPEK LIPKTIIRAS LGLKIPIYGT GKNVRDWLYV EDHVRAIELV LLKGESREIY 

       250        260        270        280        290        300 
NISAGEEKTN LEVVKIILRL MGKGEELIEL VEDRPGHDLR YSLDSWKITR DLKWRPKYTF 

       310        320        330 
DEGIKKTIDW YLKNEWWWKP LVDERILHPT PWKLKW

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 and OT3.
[2]	"Crystal structure of hypothetical protein PH0414 from Pyrococcus horikoshii OT3." Yamamoto H., Kunishima N. Submitted (JUL-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) IN COMPLEX WITH NAD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000001 Genomic DNA. Translation: BAA29500.1.

PIR

G71151.

RefSeq

NP_142398.1. NC_000961.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HUN	X-ray	2.07	A/B	1-336	[»]

ProteinModelPortal

O58151.

SMR

O58151. Positions 1-325.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBPYRT00000001946; EBPYRP00000001946; EBPYRG00000001946.

GeneID

1444312.

GenomeReviews

Gene locus PH0414 in contig BA000001_GR.

KEGG

pho:PH0414.

NMPDR

fig|70601.1.peg.412.

Organism-specific databases

CMR

Search...

Phylogenomic databases

GeneTree

EBGT00050000022750.

HOGENOM

HBG755066.

OMA

HFVRAYG.

PhylomeDB

O58151.

ProtClustDB

CLSK541405.

Enzyme and pathway databases

BioCyc

PHOR70601:PH0414-MONOMER.

Family and domain databases

InterPro

IPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

K01710.

PANTHER

PTHR10366:SF41. PTHR10366:SF41. 1 hit.

Pfam

PF01370. Epimerase. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01181. DTDP_gluc_dehyt. 1 hit.

ProtoNet

Search...

Entry information

Entry name

O58151_PYRHO

Accession

Primary (citable) accession number: O58151

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)