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Protein

Adenosylcobinamide-GDP ribazoletransferase

Gene

cobS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.UniRule annotation

Catalytic activityi

Adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin.UniRule annotation
Adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate = GMP + adenosylcobalamin 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Adenosylcobinamide-GDP ribazoletransferase (cobS)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCobalamin biosynthesis
LigandMagnesium

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-348-MONOMER
UniPathwayiUPA00148; UER00238

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobinamide-GDP ribazoletransferaseUniRule annotation (EC:2.7.8.26UniRule annotation)
Alternative name(s):
Cobalamin synthaseUniRule annotation
Cobalamin-5'-phosphate synthaseUniRule annotation
Gene namesi
Name:cobSUniRule annotation
Ordered Locus Names:PH0373
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalUniRule annotationAdd BLAST21
Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei184 – 204HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469181 – 230Adenosylcobinamide-GDP ribazoletransferaseAdd BLAST230

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0373

Family & Domainsi

Sequence similaritiesi

Belongs to the CobS family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG04338 Archaea
COG0368 LUCA
HOGENOMiHOG000228087
KOiK02233
OMAiRRELWAF
OrthoDBiPOG093Z09DJ

Family and domain databases

HAMAPiMF_00719 CobS, 1 hit
InterProiView protein in InterPro
IPR003805 CobS
PANTHERiPTHR34148 PTHR34148, 1 hit
PfamiView protein in Pfam
PF02654 CobS, 1 hit
TIGRFAMsiTIGR00317 cobS, 1 hit

Sequencei

Sequence statusi: Complete.

O58111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNILPFLTR IPIKGDFEKA RRELWAFPLV SVFTSPLPAL ILYLKVPLAS
60 70 80 90 100
ILALLSLYFT IGLLHLDGLA DWADGIMVKG DREKKIKAMK DINVGVAGIF
110 120 130 140 150
AVVTVLMLQI YSLQLVPFYA IFLAELNSKF AMLLAMATKK PLGKGLGAYF
160 170 180 190 200
MEALDRNQLL YGTLIYLLLY IPVIIAEPRN LVSFLGLFIG LYAVKISLDN
210 220 230
FGGLNGDCIG AVAEITRVGT LVVITLGWRI
Length:230
Mass (Da):25,366
Last modified:August 1, 1998 - v1
Checksum:iB08468A094AFE23A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29447.1
PIRiB71145
RefSeqiWP_010884460.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29447; BAA29447; BAA29447
GeneIDi1444247
KEGGipho:PH0373

Similar proteinsi

Entry informationi

Entry nameiCOBS_PYRHO
AccessioniPrimary (citable) accession number: O58111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health