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O58054

- PUR5_PYRHO

UniProt

O58054 - PUR5_PYRHO

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, PH0316
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-296-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:PH0316
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000148287Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0316.

Structurei

3D structure databases

ProteinModelPortaliO58054.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiPDMYGAD.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_A. AIRS_A.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

O58054-1 [UniParc]FASTAAdd to Basket

« Hide

MLTYAQAGVD EEKTAKALRA IIDAARRTFK FRMNKIGEPG DIGHYSALLD    50
FKDFYLAITT DGVGTKILVA EAVNKFDTIG IDMIAMNVND LICVGAEPVA 100
LVDYLAVKEP NEDVFQQIAK GLYEGAKEAG IAIVGGETAV MPDLINGYDL 150
AGTAVGIVEK DKVVTGEKIK PDDIVIGISS SGIHSNGLTL ARKLLIPKYG 200
LDYEYNGKKL WEWLLEPTRI YVKPILKLIN EVEVHGLAHI TGGGLLNLKR 250
LTKYGFELEM PPIDGIFKLI YENGVPLEEM FRVFNMGVGF MVIVPQEEKE 300
NALQILNKYY ESFELGKVIK EPEKIKVKNY GITL 334
Length:334
Mass (Da):36,919
Last modified:August 1, 1998 - v1
Checksum:i89C3B45DFC8CDBA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA29389.1.
PIRiF71457.
RefSeqiNP_142299.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29389; BAA29389; BAA29389.
GeneIDi1444194.
KEGGipho:PH0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000001 Genomic DNA. Translation: BAA29389.1 .
PIRi F71457.
RefSeqi NP_142299.1. NC_000961.1.

3D structure databases

ProteinModelPortali O58054.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA29389 ; BAA29389 ; BAA29389 .
GeneIDi 1444194.
KEGGi pho:PH0316.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi PDMYGAD.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci PHOR70601:GJWR-296-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_A. AIRS_A.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiPUR5_PYRHO
AccessioniPrimary (citable) accession number: O58054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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