Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-295-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:PH0316
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482871 – 334Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0316

Structurei

3D structure databases

ProteinModelPortaliO58054
SMRiO58054
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00639 Archaea
COG0150 LUCA
HOGENOMiHOG000229091
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG093Z0833

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

O58054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTYAQAGVD EEKTAKALRA IIDAARRTFK FRMNKIGEPG DIGHYSALLD
60 70 80 90 100
FKDFYLAITT DGVGTKILVA EAVNKFDTIG IDMIAMNVND LICVGAEPVA
110 120 130 140 150
LVDYLAVKEP NEDVFQQIAK GLYEGAKEAG IAIVGGETAV MPDLINGYDL
160 170 180 190 200
AGTAVGIVEK DKVVTGEKIK PDDIVIGISS SGIHSNGLTL ARKLLIPKYG
210 220 230 240 250
LDYEYNGKKL WEWLLEPTRI YVKPILKLIN EVEVHGLAHI TGGGLLNLKR
260 270 280 290 300
LTKYGFELEM PPIDGIFKLI YENGVPLEEM FRVFNMGVGF MVIVPQEEKE
310 320 330
NALQILNKYY ESFELGKVIK EPEKIKVKNY GITL
Length:334
Mass (Da):36,919
Last modified:August 1, 1998 - v1
Checksum:i89C3B45DFC8CDBA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29389.1
PIRiF71457
RefSeqiWP_010884407.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29389; BAA29389; BAA29389
GeneIDi1444194
KEGGipho:PH0316

Similar proteinsi

Entry informationi

Entry nameiPUR5_PYRHO
AccessioniPrimary (citable) accession number: O58054
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health