Reviewed,
UniProtKB/Swiss-Prot O58001 (RADA_PYRHO)
Last modified
December 15, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA repair and recombination protein radA Cleaved into the following chain: 1- Recommended name: Pho radA intein | ||||
| Gene names |
| ||||
| Organism | Pyrococcus horikoshii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 53953 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 529 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules By similarity. |
| Post-translational modification | This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential. |
| Miscellaneous | The intein interrupts the ATP-binding site. HAMAP MF_00348 |
| Sequence similarities | Belongs to the eukaryotic recA-like protein family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA recombination |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| PTM | Autocatalytic cleavage Protein splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repairInferred from electronic annotation. Source: HAMAP intein-mediated protein splicingInferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP DNA-dependent ATPase activityInferred from electronic annotation. Source: HAMAP damaged DNA bindingInferred from electronic annotation. Source: HAMAP protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 152 | 152 | DNA repair and recombination protein radA, 1st part Potential | PRO_0000030161 | |||||
| Chain | 153 – 324 | 172 | Pho radA intein Potential | PRO_0000030162 | |||||
| Chain | 325 – 529 | 205 | DNA repair and recombination protein radA, 2nd part Potential | PRO_0000030163 | |||||
Sequences
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References
| [1] | "Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. Kikuchi H.DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3. |
Cross-references
Sequence databases | |
|---|---|
| BA000001 Genomic DNA. Translation: BAA29335.1. | |
| PIR | H71450. |
| RefSeq | NP_142255.1. |
3D structure databases | |
| SMR | O58001. Positions 43-152, 325-529. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1444149. |
| GenomeReviews | Gene locus PH0263 in contig BA000001_GR. |
| KEGG | pho:PH0263. |
| NMPDR | fig|70601.1.peg.249. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG413235. |
| OMA | VIPETHN. |
Enzyme and pathway databases | |
| BioCyc | PHOR70601:PH0263-MON. |
Family and domain databases | |
| HAMAP | MF_00348. [Tree] |
| InterPro | IPR013632. DNA_recomb/repair_Rad51_C. IPR011938. DNA_recomb/repair_RadA. IPR020588. DNA_recomb_RecA/RadB_ATP-bd. IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx. IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR000445. HhH_motif. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR006141. Intein_splicing_site. IPR020587. RecA_monomer-monomer_interface. [Graphical view] |
| Pfam | PF00633. HHH. 2 hits. PF08423. Rad51. 2 hits. [Graphical view] |
| SMART | SM00278. HhH1. 2 hits. SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] |
| PROSITE | PS50818. INTEIN_C_TER. 1 hit. PS50817. INTEIN_N_TER. 1 hit. PS50162. RECA_2. 2 hits. PS50163. RECA_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RADA_PYRHO | ||||||||
| Accession | Primary (citable) accession number: O58001 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


