O58001 (RADA_PYRHO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 89.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA repair and recombination protein radA Cleaved into the following chain: | ||||
| Gene names |
| ||||
| Organism | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 70601 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus |
Protein attributes
| Sequence length | 529 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules By similarity. HAMAP MF_00348 |
| Post-translational modification | This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential. HAMAP MF_00348 |
| Miscellaneous | The intein interrupts the ATP-binding site. HAMAP MF_00348 |
| Sequence similarities | Belongs to the eukaryotic recA-like protein family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA recombination |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| PTM | Autocatalytic cleavage Protein splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA repairInferred from electronic annotation. Source: InterPro intein-mediated protein splicingInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-dependent ATPase activityInferred from electronic annotation. Source: InterPro damaged DNA bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 152 | 152 | DNA repair and recombination protein radA, 1st part Potential | PRO_0000030161 | |||||
| Chain | 153 – 324 | 172 | Pho radA intein Potential | PRO_0000030162 | |||||
| Chain | 325 – 529 | 205 | DNA repair and recombination protein radA, 2nd part Potential | PRO_0000030163 | |||||
Sequences
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References
| [1] | "Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. Kikuchi H.DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000001 Genomic DNA. Translation: BAA29335.1. |
| PIR | H71450. |
| RefSeq | NP_142255.1. NC_000961.1. |
3D structure databases | |
| ProteinModelPortal | O58001. |
| SMR | O58001. Positions 43-152, 325-529. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBPYRT00000000605; EBPYRP00000000605; EBPYRG00000000605. |
| GeneID | 1444149. |
| GenomeReviews | Gene locus PH0263 in contig BA000001_GR. |
| KEGG | pho:PH0263. |
| NMPDR | fig|70601.1.peg.249. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000022155. |
| HOGENOM | HBG413235. |
| OMA | MESIEEM. |
| PhylomeDB | O58001. |
| ProtClustDB | CLSK2561163. |
Enzyme and pathway databases | |
| BioCyc | PHOR70601:PH0263-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00348. RadA. [Tree] |
| InterPro | IPR013632. DNA_recomb/repair_Rad51_C. IPR011938. DNA_recomb/repair_RadA. IPR020588. DNA_recomb_RecA/RadB_ATP-bd. IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx. IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR006141. Intein_splice_site. IPR020587. RecA_monomer-monomer_interface. [Graphical view] |
| KO | K04483. |
| PANTHER | PTHR22942:SF11. PTHR22942:SF11. 1 hit. |
| Pfam | PF08423. Rad51. 2 hits. [Graphical view] |
| SMART | SM00278. HhH1. 2 hits. SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] |
| SUPFAM | SSF47794. Rad51_N. 1 hit. |
| TIGRFAMs | TIGR01443. Intein_Cterm. 1 hit. TIGR01445. Intein_Nterm. 1 hit. TIGR02236. Recomb_radA. 1 hit. |
| PROSITE | PS50818. INTEIN_C_TER. 1 hit. PS50817. INTEIN_N_TER. 1 hit. PS50162. RECA_2. 2 hits. PS50163. RECA_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RADA_PYRHO | ||||||||
| Accession | Primary (citable) accession number: O58001 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with