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O57981

- GLMS_PYRHO

UniProt

O57981 - GLMS_PYRHO

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei593 – 5931For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-234-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:PH0243
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135431Add
    BLAST

    Proteomic databases

    PRIDEiO57981.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi70601.PH0243.

    Structurei

    3D structure databases

    ProteinModelPortaliO57981.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini280 – 420141SIS 1UniRule annotationAdd
    BLAST
    Domaini449 – 588140SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258898.
    KOiK00820.
    OMAiFYTHAGP.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O57981-1 [UniParc]FASTAAdd to Basket

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    MCGIIGYIGP RKASDVIVEG LKRLEYRGYD SAGIATCYEG KIFIKKGAGK    50
    IDELVKKLNF LELPGNIGIG HTRWATHGIP NDTNAHPHTD CTGKIVVVHN 100
    GIIENFQELK RELLKRGHVF RSDTDTEVIA HLIEENLRIT GNFEDAFRMS 150
    LLRLRGSYAL VVLFADDPER LYIARKDSPL IIGIGKGEMF MASDIPAFLA 200
    YTRRAVFLDD GEYGIVSKDW FTIKDIITGA VKTKEIHEIQ WTLEMAEKGG 250
    YEHFMLKEIF EQPKAIKDAI YGNVKEAPKV AELLMKYDRI IITGMGTSYH 300
    AALVGKYLIQ RFGKVPVIVE EASELRYEYE DILDNRSLLI AITQSGETAD 350
    TVAAMKLAKS KGVEVVGIVN VVGSLATRIA DETLYTHAGP EIGVAATKTY 400
    TTQLVVLTLL AKELGKLVGI DVSQIEGTIP RLPELVDSSL KINDKIREIA 450
    VKLNDKRDFF YIGRGINYPT ALEGALKIKE IAYVHAEGLS AGELKHGPLA 500
    LIEDGIPVVG IAPTGKTFEK MLSNIEEAKA RGGFIISLGD DVRLHQVSDI 550
    FIRLPKVPEE LAPITYIVPL QLLAYHLAVL KGHNPDRPRN LAKSVTVE 598
    Length:598
    Mass (Da):66,110
    Last modified:January 23, 2007 - v3
    Checksum:i3A8DD0466416544D
    GO

    Sequence cautioni

    The sequence BAA29315.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29315.1. Different initiation.
    PIRiD71248.
    RefSeqiNP_142239.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA29315; BAA29315; BAA29315.
    GeneIDi1444133.
    KEGGipho:PH0243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29315.1 . Different initiation.
    PIRi D71248.
    RefSeqi NP_142239.1. NC_000961.1.

    3D structure databases

    ProteinModelPortali O57981.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH0243.

    Protein family/group databases

    MEROPSi C44.971.

    Proteomic databases

    PRIDEi O57981.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA29315 ; BAA29315 ; BAA29315 .
    GeneIDi 1444133.
    KEGGi pho:PH0243.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258898.
    KOi K00820.
    OMAi FYTHAGP.

    Enzyme and pathway databases

    BioCyci PHOR70601:GJWR-234-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiGLMS_PYRHO
    AccessioniPrimary (citable) accession number: O57981
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3