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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.6 5244
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)
Alternative name(s):
SAICAR synthetase
Gene namesi
Name:purC
Ordered Locus Names:PH0239
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001009161 – 238Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST238

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0239

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 17Combined sources5
Beta strandi19 – 27Combined sources9
Beta strandi29 – 33Combined sources5
Turni34 – 37Combined sources4
Beta strandi38 – 41Combined sources4
Helixi45 – 62Combined sources18
Beta strandi67 – 72Combined sources6
Beta strandi77 – 81Combined sources5
Beta strandi87 – 95Combined sources9
Helixi98 – 102Combined sources5
Beta strandi111 – 121Combined sources11
Turni124 – 127Combined sources4
Helixi133 – 138Combined sources6
Helixi143 – 165Combined sources23
Turni166 – 168Combined sources3
Beta strandi169 – 176Combined sources8
Beta strandi178 – 180Combined sources3
Beta strandi186 – 188Combined sources3
Turni194 – 196Combined sources3
Beta strandi197 – 201Combined sources5
Turni202 – 204Combined sources3
Helixi211 – 214Combined sources4
Helixi220 – 232Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U54X-ray2.35A/B1-238[»]
3U55X-ray1.90A1-238[»]
4O7LX-ray2.10A1-238[»]
4O7NX-ray2.16A1-238[»]
4O7RX-ray2.35A1-238[»]
4O7SX-ray2.24A1-238[»]
4O7TX-ray2.10A1-238[»]
4O7VX-ray2.30A1-238[»]
4O7WX-ray2.20A1-238[»]
4O7YX-ray2.00A1-238[»]
4O7ZX-ray2.30A1-238[»]
4O81X-ray2.10A/B1-238[»]
4O82X-ray2.16A/B1-238[»]
4O83X-ray2.05A/B1-238[»]
4O84X-ray2.09A/B1-238[»]
4O86X-ray2.20A1-238[»]
ProteinModelPortaliO57978
SMRiO57978
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.Curated

Phylogenomic databases

eggNOGiarCOG04421 Archaea
COG0152 LUCA
HOGENOMiHOG000082629
KOiK01923
OMAiFNAQKRG
OrthoDBiPOG093Z09AB

Family and domain databases

CDDicd01415 SAICAR_synt_PurC, 1 hit
HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR033934 SAICAR_synt_PurC
IPR001636 SAICAR_synth
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O57978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLMEVYEG KAKKMIPIDD DKLIMEFKDD ATAFDGTKKA RFKGKGWLNA
60 70 80 90 100
QLSVIFFKLL EEHGIKTHFI GVAGGNRLIV EKLDMYPLEV VVRNVVAGSL
110 120 130 140 150
KKRLPLPEGY ELPEPIVELY YKNDELHDPM INYYHAKVLG ISLDEIKKIE
160 170 180 190 200
EIALKVNEIL KDYLAKKGII LVDFKLEFGK DKNGDIVLAD EISPDTCRFW
210 220 230
DAKTKRSLDK DVFRFDKGDL IEAYKEIYER ITGEKPEF
Length:238
Mass (Da):27,436
Last modified:August 1, 1998 - v1
Checksum:i2C161C59792486E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29311.1
PIRiH71247

Genome annotation databases

EnsemblBacteriaiBAA29311; BAA29311; BAA29311
KEGGipho:PH0239

Similar proteinsi

Entry informationi

Entry nameiPUR7_PYRHO
AccessioniPrimary (citable) accession number: O57978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health