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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.6. 5244.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)
Alternative name(s):
SAICAR synthetase
Gene namesi
Name:purC
Ordered Locus Names:PH0239
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001009161 – 238Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST238

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0239.

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 17Combined sources5
Beta strandi19 – 27Combined sources9
Beta strandi29 – 33Combined sources5
Turni34 – 37Combined sources4
Beta strandi38 – 41Combined sources4
Helixi45 – 62Combined sources18
Beta strandi67 – 72Combined sources6
Beta strandi77 – 81Combined sources5
Beta strandi87 – 95Combined sources9
Helixi98 – 102Combined sources5
Beta strandi111 – 121Combined sources11
Turni124 – 127Combined sources4
Helixi133 – 138Combined sources6
Helixi143 – 165Combined sources23
Turni166 – 168Combined sources3
Beta strandi169 – 176Combined sources8
Beta strandi178 – 180Combined sources3
Beta strandi186 – 188Combined sources3
Turni194 – 196Combined sources3
Beta strandi197 – 201Combined sources5
Turni202 – 204Combined sources3
Helixi211 – 214Combined sources4
Helixi220 – 232Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U54X-ray2.35A/B1-238[»]
3U55X-ray1.90A1-238[»]
4O7LX-ray2.10A1-238[»]
4O7NX-ray2.16A1-238[»]
4O7RX-ray2.35A1-238[»]
4O7SX-ray2.24A1-238[»]
4O7TX-ray2.10A1-238[»]
4O7VX-ray2.30A1-238[»]
4O7WX-ray2.20A1-238[»]
4O7YX-ray2.00A1-238[»]
4O7ZX-ray2.30A1-238[»]
4O81X-ray2.10A/B1-238[»]
4O82X-ray2.16A/B1-238[»]
4O83X-ray2.05A/B1-238[»]
4O84X-ray2.09A/B1-238[»]
4O86X-ray2.20A1-238[»]
ProteinModelPortaliO57978.
SMRiO57978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.Curated

Phylogenomic databases

eggNOGiarCOG04421. Archaea.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLMEVYEG KAKKMIPIDD DKLIMEFKDD ATAFDGTKKA RFKGKGWLNA
60 70 80 90 100
QLSVIFFKLL EEHGIKTHFI GVAGGNRLIV EKLDMYPLEV VVRNVVAGSL
110 120 130 140 150
KKRLPLPEGY ELPEPIVELY YKNDELHDPM INYYHAKVLG ISLDEIKKIE
160 170 180 190 200
EIALKVNEIL KDYLAKKGII LVDFKLEFGK DKNGDIVLAD EISPDTCRFW
210 220 230
DAKTKRSLDK DVFRFDKGDL IEAYKEIYER ITGEKPEF
Length:238
Mass (Da):27,436
Last modified:August 1, 1998 - v1
Checksum:i2C161C59792486E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29311.1.
PIRiH71247.

Genome annotation databases

EnsemblBacteriaiBAA29311; BAA29311; BAA29311.
KEGGipho:PH0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29311.1.
PIRiH71247.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U54X-ray2.35A/B1-238[»]
3U55X-ray1.90A1-238[»]
4O7LX-ray2.10A1-238[»]
4O7NX-ray2.16A1-238[»]
4O7RX-ray2.35A1-238[»]
4O7SX-ray2.24A1-238[»]
4O7TX-ray2.10A1-238[»]
4O7VX-ray2.30A1-238[»]
4O7WX-ray2.20A1-238[»]
4O7YX-ray2.00A1-238[»]
4O7ZX-ray2.30A1-238[»]
4O81X-ray2.10A/B1-238[»]
4O82X-ray2.16A/B1-238[»]
4O83X-ray2.05A/B1-238[»]
4O84X-ray2.09A/B1-238[»]
4O86X-ray2.20A1-238[»]
ProteinModelPortaliO57978.
SMRiO57978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29311; BAA29311; BAA29311.
KEGGipho:PH0239.

Phylogenomic databases

eggNOGiarCOG04421. Archaea.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BRENDAi6.3.2.6. 5244.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUR7_PYRHO
AccessioniPrimary (citable) accession number: O57978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.