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Protein

Digeranylgeranylglycerophospholipid reductase

Gene

PH0181

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.UniRule annotation

Miscellaneous

Reduction reaction proceeds via syn addition of hydrogen for double bonds.UniRule annotation

Catalytic activityi

A 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95FADUniRule annotation1
Binding sitei274FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 13FADUniRule annotation5
Nucleotide bindingi32 – 34FADUniRule annotation3
Nucleotide bindingi43 – 46FADUniRule annotation4
Nucleotide bindingi286 – 287FADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-171-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglycerophospholipid reductaseUniRule annotation (EC:1.3.7.11UniRule annotation)
Short name:
DGGGPL reductaseUniRule annotation
Alternative name(s):
2,3-bis-O-geranylgeranylglyceryl phosphate reductaseUniRule annotation
Geranylgeranyl reductaseUniRule annotation
Short name:
GGRUniRule annotation
Gene namesi
Ordered Locus Names:PH0181
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003514771 – 393Digeranylgeranylglycerophospholipid reductaseAdd BLAST393

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0181

Structurei

3D structure databases

ProteinModelPortaliO57920
SMRiO57920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 209Substrate bindingUniRule annotation7
Regioni282 – 285Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00570 Archaea
COG0644 LUCA
HOGENOMiHOG000226367
KOiK17830
OMAiWITSHLE
OrthoDBiPOG093Z0344

Family and domain databases

Gene3Di3.50.50.60, 3 hits
HAMAPiMF_01287 DGGGPL_reductase, 1 hit
InterProiView protein in InterPro
IPR023590 DGGGPL_reductase
IPR036188 FAD/NAD-bd_sf
IPR011777 Geranylgeranyl_Rdtase_fam
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR02032 GG-red-SF, 1 hit

Sequencei

Sequence statusi: Complete.

O57920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYDVVVVGS GVAGPIVARN VAKAGFSVLL VDKKPAIGAP KQCAEGLTIN
60 70 80 90 100
AFKQFDIPYD KRFINREIYG AKIYSPSGYT AELRYKEVSG VILERKVFDK
110 120 130 140 150
MLAYYAAKAG AEVLARTEVV DVIRREGKIV GVKAKHEGEP MEIEAKVIVA
160 170 180 190 200
ADGVESTIAR KAGIDTYAPP HEFDSGYEYE MIIEGFDPDL IHLFFGNEVA
210 220 230 240 250
PRGYVWVFPK DEDRANVGIG INSDNEKTAK YYLDKWLKEN NIPRNKILEV
260 270 280 290 300
NVGLIPVGGF VKELVKENVL VVGDAARQVN PIHGGGMAEA MKASTIASKW
310 320 330 340 350
IIKALEEENL ELLKNYKEEW WKTEGPRMEK LLRLRRAMEK LTDEDLDVFV
360 370 380 390
QLVSGTDLEK IAGGNYIEVV KALMKHPKVL MSRRRLEILK ALL
Length:393
Mass (Da):43,929
Last modified:August 1, 1998 - v1
Checksum:i6BEC7E0B71C0D48C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29250.1
PIRiC71240
RefSeqiWP_010884290.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29250; BAA29250; BAA29250
GeneIDi1444072
KEGGipho:PH0181

Similar proteinsi

Entry informationi

Entry nameiGGR_PYRHO
AccessioniPrimary (citable) accession number: O57920
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health