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Protein
Submitted name:

235aa long hypothetical biotin--[acetyl-CoA-carboxylase] ligase

Gene

PH0147

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42Biotin 1Combined sources1
Metal bindingi103MagnesiumCombined sources1
Metal bindingi103ManganeseCombined sources1
Metal bindingi104MagnesiumCombined sources1
Metal bindingi104ManganeseCombined sources1
Binding sitei111ADPCombined sources1
Binding sitei111ATPCombined sources1
Binding sitei111Biotin 1Combined sources1
Binding sitei115Biotin 1Combined sources1
Binding sitei131ADPCombined sources1
Binding sitei131ATPCombined sources1
Binding sitei211Biotin 2Combined sources1
Binding sitei227ATPCombined sources1
Binding sitei227Biotin 2; via amide nitrogenCombined sources1
Binding sitei233ADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 54ADPCombined sources7
Nucleotide bindingi48 – 54ATPCombined sources7
Nucleotide bindingi100 – 104ATPCombined sources5
Nucleotide bindingi103 – 104ADPCombined sources2
Nucleotide bindingi231 – 233ATPCombined sources3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Keywords - Ligandi

ATP-bindingCombined sources, BiotinCombined sources, MagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-144-MONOMER.
BRENDAi6.3.4.15. 5244.

Names & Taxonomyi

Protein namesi
Submitted name:
235aa long hypothetical biotin--[acetyl-CoA-carboxylase] ligaseImported
Gene namesi
Ordered Locus Names:PH0147Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0147.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WNLX-ray1.60A/B1-235[»]
1WPYX-ray1.60A/B1-235[»]
1WQ7X-ray1.60A/B1-235[»]
1WQWX-ray1.45A/B1-235[»]
1X01X-ray2.00A/B1-235[»]
2DEQX-ray1.85A/B1-235[»]
2DJZX-ray1.85A/B1-235[»]
2DKGX-ray2.00A/B1-235[»]
2DTHX-ray1.95A/B1-235[»]
2DTIX-ray2.20A/B1-235[»]
2DTOX-ray1.50A/B1-235[»]
2DVEX-ray1.60A/B1-235[»]
2DXTX-ray1.60A/B1-235[»]
2DXUX-ray1.28A/B1-235[»]
2DZ9X-ray1.84A/B1-235[»]
2DZCX-ray1.45A/B1-235[»]
2E10X-ray1.35A/B1-235[»]
2E1HX-ray1.40A/B1-235[»]
2E41X-ray1.75A/B1-235[»]
2E64X-ray1.50A/B1-235[»]
2E65X-ray1.65A/B1-235[»]
2EJFX-ray2.00A/B1-235[»]
2EJGX-ray2.71A/B1-235[»]
2FYKX-ray1.60A/B1-235[»]
2HNIX-ray1.90A/B1-235[»]
2ZGWX-ray1.50A/B1-235[»]
ProteinModelPortaliO57883.
SMRiO57883.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO57883.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 173BPL/LPL catalyticInterPro annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Biotin 1 bindingCombined sources3
Regioni46 – 53Biotin 1 bindingCombined sources8
Regioni103 – 104Biotin 1 bindingCombined sources2

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
HOGENOMiHOG000041811.
KOiK03524.
OMAiRKWESPE.

Family and domain databases

InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
IPR008988. Transcriptional_repressor_C.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLKTSIIG RRVIYFQEIT STNEFAKTSY LEEGTVIVAD KQTMGHGRLN
60 70 80 90 100
RKWESPEGGL WLSIVLSPKV PQKDLPKIVF LGAVGVVETL KEFSIDGRIK
110 120 130 140 150
WPNDVLVNYK KIAGVLVEGK GDKIVLGIGL NVNNKVPNGA TSMKLELGSE
160 170 180 190 200
VPLLSVFRSL ITNLDRLYLN FLKNPMDILN LVRDNMILGV RVKILGDGSF
210 220 230
EGIAEDIDDF GRLIIRLDSG EVKKVIYGDV SLRFL
Length:235
Mass (Da):26,072
Last modified:August 1, 1998 - v1
Checksum:i65C77DFB16A3F029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29216.1.
PIRiA71236.
RefSeqiWP_010884259.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29216; BAA29216; BAA29216.
GeneIDi1444041.
KEGGipho:PH0147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29216.1.
PIRiA71236.
RefSeqiWP_010884259.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WNLX-ray1.60A/B1-235[»]
1WPYX-ray1.60A/B1-235[»]
1WQ7X-ray1.60A/B1-235[»]
1WQWX-ray1.45A/B1-235[»]
1X01X-ray2.00A/B1-235[»]
2DEQX-ray1.85A/B1-235[»]
2DJZX-ray1.85A/B1-235[»]
2DKGX-ray2.00A/B1-235[»]
2DTHX-ray1.95A/B1-235[»]
2DTIX-ray2.20A/B1-235[»]
2DTOX-ray1.50A/B1-235[»]
2DVEX-ray1.60A/B1-235[»]
2DXTX-ray1.60A/B1-235[»]
2DXUX-ray1.28A/B1-235[»]
2DZ9X-ray1.84A/B1-235[»]
2DZCX-ray1.45A/B1-235[»]
2E10X-ray1.35A/B1-235[»]
2E1HX-ray1.40A/B1-235[»]
2E41X-ray1.75A/B1-235[»]
2E64X-ray1.50A/B1-235[»]
2E65X-ray1.65A/B1-235[»]
2EJFX-ray2.00A/B1-235[»]
2EJGX-ray2.71A/B1-235[»]
2FYKX-ray1.60A/B1-235[»]
2HNIX-ray1.90A/B1-235[»]
2ZGWX-ray1.50A/B1-235[»]
ProteinModelPortaliO57883.
SMRiO57883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29216; BAA29216; BAA29216.
GeneIDi1444041.
KEGGipho:PH0147.

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
HOGENOMiHOG000041811.
KOiK03524.
OMAiRKWESPE.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-144-MONOMER.
BRENDAi6.3.4.15. 5244.

Miscellaneous databases

EvolutionaryTraceiO57883.

Family and domain databases

InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
IPR008988. Transcriptional_repressor_C.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO57883_PYRHO
AccessioniPrimary (citable) accession number: O57883
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.