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Protein
Submitted name:

235aa long hypothetical biotin--[acetyl-CoA-carboxylase] ligase

Gene

PH0147

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Biotin 1Combined sources
Metal bindingi103 – 1031MagnesiumCombined sources
Metal bindingi103 – 1031ManganeseCombined sources
Metal bindingi104 – 1041MagnesiumCombined sources
Metal bindingi104 – 1041ManganeseCombined sources
Binding sitei111 – 1111ADPCombined sources
Binding sitei111 – 1111ATPCombined sources
Binding sitei111 – 1111Biotin 1Combined sources
Binding sitei115 – 1151Biotin 1Combined sources
Binding sitei131 – 1311ADPCombined sources
Binding sitei131 – 1311ATPCombined sources
Binding sitei211 – 2111Biotin 2Combined sources
Binding sitei227 – 2271ATPCombined sources
Binding sitei227 – 2271Biotin 2; via amide nitrogenCombined sources
Binding sitei233 – 2331ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 547ADPCombined sources
Nucleotide bindingi48 – 547ATPCombined sources
Nucleotide bindingi100 – 1045ATPCombined sources
Nucleotide bindingi103 – 1042ADPCombined sources
Nucleotide bindingi231 – 2333ATPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Keywords - Ligandi

ATP-bindingCombined sources, BiotinCombined sources, MagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-144-MONOMER.
BRENDAi6.3.4.15. 5244.

Names & Taxonomyi

Protein namesi
Submitted name:
235aa long hypothetical biotin--[acetyl-CoA-carboxylase] ligaseImported
Gene namesi
Ordered Locus Names:PH0147Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0147.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WNLX-ray1.60A/B1-235[»]
1WPYX-ray1.60A/B1-235[»]
1WQ7X-ray1.60A/B1-235[»]
1WQWX-ray1.45A/B1-235[»]
1X01X-ray2.00A/B1-235[»]
2DEQX-ray1.85A/B1-235[»]
2DJZX-ray1.85A/B1-235[»]
2DKGX-ray2.00A/B1-235[»]
2DTHX-ray1.95A/B1-235[»]
2DTIX-ray2.20A/B1-235[»]
2DTOX-ray1.50A/B1-235[»]
2DVEX-ray1.60A/B1-235[»]
2DXTX-ray1.60A/B1-235[»]
2DXUX-ray1.28A/B1-235[»]
2DZ9X-ray1.84A/B1-235[»]
2DZCX-ray1.45A/B1-235[»]
2E10X-ray1.35A/B1-235[»]
2E1HX-ray1.40A/B1-235[»]
2E41X-ray1.75A/B1-235[»]
2E64X-ray1.50A/B1-235[»]
2E65X-ray1.65A/B1-235[»]
2EJFX-ray2.00A/B1-235[»]
2EJGX-ray2.71A/B1-235[»]
2FYKX-ray1.60A/B1-235[»]
2HNIX-ray1.90A/B1-235[»]
2ZGWX-ray1.50A/B1-235[»]
ProteinModelPortaliO57883.
SMRiO57883. Positions 1-235.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO57883.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 173173BPL/LPL catalyticInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Biotin 1 bindingCombined sources
Regioni46 – 538Biotin 1 bindingCombined sources
Regioni103 – 1042Biotin 1 bindingCombined sources

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
HOGENOMiHOG000041811.
KOiK03524.
OMAiRKWESPE.

Family and domain databases

InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
IPR008988. Transcriptional_repressor_C.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLKTSIIG RRVIYFQEIT STNEFAKTSY LEEGTVIVAD KQTMGHGRLN
60 70 80 90 100
RKWESPEGGL WLSIVLSPKV PQKDLPKIVF LGAVGVVETL KEFSIDGRIK
110 120 130 140 150
WPNDVLVNYK KIAGVLVEGK GDKIVLGIGL NVNNKVPNGA TSMKLELGSE
160 170 180 190 200
VPLLSVFRSL ITNLDRLYLN FLKNPMDILN LVRDNMILGV RVKILGDGSF
210 220 230
EGIAEDIDDF GRLIIRLDSG EVKKVIYGDV SLRFL
Length:235
Mass (Da):26,072
Last modified:August 1, 1998 - v1
Checksum:i65C77DFB16A3F029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29216.1.
PIRiA71236.
RefSeqiWP_010884259.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29216; BAA29216; BAA29216.
GeneIDi1444041.
KEGGipho:PH0147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29216.1.
PIRiA71236.
RefSeqiWP_010884259.1. NC_000961.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WNLX-ray1.60A/B1-235[»]
1WPYX-ray1.60A/B1-235[»]
1WQ7X-ray1.60A/B1-235[»]
1WQWX-ray1.45A/B1-235[»]
1X01X-ray2.00A/B1-235[»]
2DEQX-ray1.85A/B1-235[»]
2DJZX-ray1.85A/B1-235[»]
2DKGX-ray2.00A/B1-235[»]
2DTHX-ray1.95A/B1-235[»]
2DTIX-ray2.20A/B1-235[»]
2DTOX-ray1.50A/B1-235[»]
2DVEX-ray1.60A/B1-235[»]
2DXTX-ray1.60A/B1-235[»]
2DXUX-ray1.28A/B1-235[»]
2DZ9X-ray1.84A/B1-235[»]
2DZCX-ray1.45A/B1-235[»]
2E10X-ray1.35A/B1-235[»]
2E1HX-ray1.40A/B1-235[»]
2E41X-ray1.75A/B1-235[»]
2E64X-ray1.50A/B1-235[»]
2E65X-ray1.65A/B1-235[»]
2EJFX-ray2.00A/B1-235[»]
2EJGX-ray2.71A/B1-235[»]
2FYKX-ray1.60A/B1-235[»]
2HNIX-ray1.90A/B1-235[»]
2ZGWX-ray1.50A/B1-235[»]
ProteinModelPortaliO57883.
SMRiO57883. Positions 1-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29216; BAA29216; BAA29216.
GeneIDi1444041.
KEGGipho:PH0147.

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
HOGENOMiHOG000041811.
KOiK03524.
OMAiRKWESPE.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-144-MONOMER.
BRENDAi6.3.4.15. 5244.

Miscellaneous databases

EvolutionaryTraceiO57883.

Family and domain databases

InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
IPR008988. Transcriptional_repressor_C.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO57883_PYRHO
AccessioniPrimary (citable) accession number: O57883
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.