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O57863 (DP2S_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase II small subunit
Short name=Pol II
EC=2.7.7.7
Gene names
Name:polB
Ordered Locus Names:PH0123
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity. HAMAP MF_00325

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_00325

Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates. HAMAP MF_00325

Subunit structure

Heterodimer of a large subunit and a small subunit By similarity.

Sequence similarities

Belongs to the DNA polymerase delta/II small subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622DNA polymerase II small subunit HAMAP MF_00325
PRO_0000096181

Secondary structure

1 ............ 622
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O57863 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 28C4D84D9163274D

FASTA62270,283
        10         20         30         40         50         60 
MDEFVKGLMK NGYLITPSAY YLLVGHFNEG KFSLIELIKF AKSRETFIID DEIANEFLKS 

        70         80         90        100        110        120 
IGAEVELPQE IKEGYISTGE GSQKVPDHEE LEKITNESSV ESSISTGETP KTEELQPTLD 

       130        140        150        160        170        180 
ILEEEIGDIE GGESSISTGD EVPEVENNNG GTVVVFDKYG YPFTYVPEEI EEELEEYPKY 

       190        200        210        220        230        240 
EDVTIEINPN LEVVPIEKDY EIKFDVRRVK LKPPKVKSGS GKEGEIIVEA YASLFRSRLR 

       250        260        270        280        290        300 
KLRRILRENP EVSNVIDIKK LKYVKGDEEV TIIGLVNSKK ETSKGLIFEV EDQTDRVKVF 

       310        320        330        340        350        360 
LPKDSEDYRE ALKVLPDAVV AFKGVYSKRG IFFANRFYLP DVPLYRKQKP PLEEKVYAVL 

       370        380        390        400        410        420 
TSDIHVGSKE FCEKAFIKFL EWLNGYVESK EEEEIVSRIR YLIIAGDVVD GIGIYPGQYS 

       430        440        450        460        470        480 
DLIIPDIFDQ YEALANLLSN VPKHITIFIG PGNHDAARPA IPQPEFYEEY AKPLYKLKNT 

       490        500        510        520        530        540 
VIISNPAVIR LHGRDFLIAH GRGIEDVVSF VPGLTHHKPG LPMVELLKMR HLAPTFGGKV 

       550        560        570        580        590        600 
PIAPDPEDLL VIEEVPDLVQ MGHVHVYDTA VYRGVQLVNS ATWQAQTEFQ KMVNIVPTPG 

       610        620 
LVPIVDVESA RVIKVLDFSR WC

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000001 Genomic DNA. Translation: BAA29192.1.
PIRA71233.
RefSeqNP_142131.1. NC_000961.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KXENMR-A1-72[»]
ProteinModelPortalO57863.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1502431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000001346; EBPYRP00000001346; EBPYRG00000001346.
GeneID1444019.
GenomeReviewsGene locus PH0123 in contig BA000001_GR.
KEGGpho:PH0123.
NMPDRfig|70601.1.peg.119.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022734.
HOGENOMHBG726778.
OMAIPDIFDQ.
ProtClustDBPRK04036.

Enzyme and pathway databases

BioCycPHOR70601:PH0123-MONOMER.

Family and domain databases

HAMAPMF_00325. DNApol_II_A_arch.
[Tree]
InterProIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA-helicase.
IPR011149. Pol2_small_arc.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK02323.
PANTHERPTHR10416. PTHR10416. 1 hit.
PfamPF04042. DNA_pol_E_B. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PIRSFPIRSF000803. Arc_Pol2_small. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDP2S_PYRHO
AccessionPrimary (citable) accession number: O57863
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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