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Protein

Replication factor C large subunit

Gene

rfcL

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-112-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C large subunitUniRule annotation
Short name:
RFC large subunitUniRule annotation
Alternative name(s):
Clamp loader large subunitUniRule annotation
Gene namesi
Name:rfcLUniRule annotation
Ordered Locus Names:PH0113
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Replication factor C large subunitPRO_0000135963Add
BLAST

Interactioni

Subunit structurei

Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0113.

Structurei

3D structure databases

ProteinModelPortaliO57853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family. RfcL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00470. Archaea.
COG0470. LUCA.
HOGENOMiHOG000271062.
KOiK04800.
OMAiAQRTGNY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01508. RfcL. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
IPR023935. Rep_factor-C_lsu.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O57853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVPWIEKY RPRKLSEIVN QEQALEKVRA WIESWLHGNP PKKKALLLAG
60 70 80 90 100
PPGSGKTTTV YALAHEYNFE VIELNASDER TYNKIARYVQ AAYTMDIMGK
110 120 130 140 150
RRKIIFLDEA DNIEPSGAPE IAKLIDKARN PIIMAANHYW EVPKEIRDRA
160 170 180 190 200
ELVEYKRLNQ RDVISALVRI LKREGITVPK EILTEIAKRS SGDLRAAIND
210 220 230 240 250
LQTIVAGGYE DAKYVLAYRD VEKTVFQSLG MVFSSDNAKR AKLALMNLDM
260 270 280 290 300
SPDEFLLWVD ENIPHMYLKP EEMARAYEAI SRADIYLGRA QRTGNYSLWK
310 320 330 340 350
YAIDMMTAGV AVAGTKKKGF AKFYPPNTLK MLAESKEERS IRDSIIKKIM
360 370 380 390 400
KEMHMSKLEA LETMKILRTI FENNLDLAAH FTVFLELTEK EVEFLAGKEK
410 420 430 440 450
AGTIWGKTLS IRRRIKETEK IEEKAVEEKV EEEEAEEEEE EERKEEEKPK
460
AEKKKGKQVT LFDFIKKN
Length:468
Mass (Da):53,913
Last modified:August 1, 1998 - v1
Checksum:iB85739AD2760B5AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29182.1.
PIRiG71231.
RefSeqiWP_010884229.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29182; BAA29182; BAA29182.
GeneIDi1444011.
KEGGipho:PH0113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29182.1.
PIRiG71231.
RefSeqiWP_010884229.1. NC_000961.1.

3D structure databases

ProteinModelPortaliO57853.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29182; BAA29182; BAA29182.
GeneIDi1444011.
KEGGipho:PH0113.

Phylogenomic databases

eggNOGiarCOG00470. Archaea.
COG0470. LUCA.
HOGENOMiHOG000271062.
KOiK04800.
OMAiAQRTGNY.

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-112-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01508. RfcL. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
IPR023935. Rep_factor-C_lsu.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRFCL_PYRHO
AccessioniPrimary (citable) accession number: O57853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.