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Protein

Replication factor C large subunit

Gene

rfcL

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-108-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C large subunitUniRule annotation
Short name:
RFC large subunitUniRule annotation
Alternative name(s):
Clamp loader large subunitUniRule annotation
Gene namesi
Name:rfcLUniRule annotation
Ordered Locus Names:PH0113
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001359631 – 468Replication factor C large subunitAdd BLAST468

Interactioni

Subunit structurei

Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).UniRule annotation

Protein-protein interaction databases

STRINGi70601.PH0113

Structurei

3D structure databases

ProteinModelPortaliO57853
SMRiO57853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the activator 1 small subunits family. RfcL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00470 Archaea
COG0470 LUCA
HOGENOMiHOG000271062
KOiK04800
OMAiGGWTRYG
OrthoDBiPOG093Z03G8

Family and domain databases

HAMAPiMF_01508 RfcL, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
IPR023935 Rep_factor-C_lsu
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

O57853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVPWIEKY RPRKLSEIVN QEQALEKVRA WIESWLHGNP PKKKALLLAG
60 70 80 90 100
PPGSGKTTTV YALAHEYNFE VIELNASDER TYNKIARYVQ AAYTMDIMGK
110 120 130 140 150
RRKIIFLDEA DNIEPSGAPE IAKLIDKARN PIIMAANHYW EVPKEIRDRA
160 170 180 190 200
ELVEYKRLNQ RDVISALVRI LKREGITVPK EILTEIAKRS SGDLRAAIND
210 220 230 240 250
LQTIVAGGYE DAKYVLAYRD VEKTVFQSLG MVFSSDNAKR AKLALMNLDM
260 270 280 290 300
SPDEFLLWVD ENIPHMYLKP EEMARAYEAI SRADIYLGRA QRTGNYSLWK
310 320 330 340 350
YAIDMMTAGV AVAGTKKKGF AKFYPPNTLK MLAESKEERS IRDSIIKKIM
360 370 380 390 400
KEMHMSKLEA LETMKILRTI FENNLDLAAH FTVFLELTEK EVEFLAGKEK
410 420 430 440 450
AGTIWGKTLS IRRRIKETEK IEEKAVEEKV EEEEAEEEEE EERKEEEKPK
460
AEKKKGKQVT LFDFIKKN
Length:468
Mass (Da):53,913
Last modified:August 1, 1998 - v1
Checksum:iB85739AD2760B5AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29182.1
PIRiG71231
RefSeqiWP_010884229.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29182; BAA29182; BAA29182
GeneIDi1444011
KEGGipho:PH0113

Similar proteinsi

Entry informationi

Entry nameiRFCL_PYRHO
AccessioniPrimary (citable) accession number: O57853
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health