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Protein

Alanyl-tRNA editing protein AlaX-M

Gene

alaXM

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in trans to edit the amino acid moiety from mischarged charged Gly-tRNA(Ala) and Ser-tRNA(Ala).1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99Zinc1
Metal bindingi103Zinc1
Metal bindingi182Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.1.1.29. 5244.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanyl-tRNA editing protein AlaX-M
Short name:
AlaX-M
Alternative name(s):
Alanyl-tRNA deacylase AlaX-M
Gene namesi
Name:alaXM
Ordered Locus Names:PH0108
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003916481 – 216Alanyl-tRNA editing protein AlaX-MAdd BLAST216

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi70601.PH0108.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 20Combined sources4
Beta strandi49 – 51Combined sources3
Beta strandi54 – 60Combined sources7
Beta strandi68 – 72Combined sources5
Helixi74 – 76Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi83 – 87Combined sources5
Helixi89 – 113Combined sources25
Turni114 – 116Combined sources3
Beta strandi119 – 122Combined sources4
Beta strandi127 – 135Combined sources9
Helixi140 – 143Combined sources4
Helixi144 – 157Combined sources14
Beta strandi160 – 168Combined sources9
Beta strandi170 – 174Combined sources5
Helixi190 – 192Combined sources3
Beta strandi196 – 205Combined sources10
Beta strandi208 – 215Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E1BX-ray2.70A1-216[»]
ProteinModelPortaliO57848.
SMRiO57848.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO57848.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01254. Archaea.
COG2872. LUCA.
HOGENOMiHOG000230779.
KOiK01872.
OMAiVWHVVAE.

Family and domain databases

InterProiIPR018165. Ala-tRNA-synth_IIc_core.
IPR018164. Ala-tRNA-synth_IIc_N.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR009000. Transl_B-barrel.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF01411. tRNA-synt_2c. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF55186. SSF55186. 1 hit.
PROSITEiPS50860. AA_TRNA_LIGASE_II_ALA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O57848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINMTRKLYY EDAYLKEAKG RVLEIRDNAI LLDQTIFYPT GGGQPHDRGT
60 70 80 90 100
INGVEVLDVY KDEEGNVWHV VKEPEKFKVG DEVELKIDWD YRYKLMRIHT
110 120 130 140 150
GLHLLEHVLN EVLGEGNWQL VGSGMSVEKG RYDIAYPENL NKYKEQIISL
160 170 180 190 200
FNKYVDEGGE VKIWWEGDRR YTQIRDFEVI PCGGTHVKDI KEIGHIKKLK
210
RSSIGRGKQR LEMWLE
Length:216
Mass (Da):25,299
Last modified:August 1, 1998 - v1
Checksum:i4B4D94685C47EF32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29177.1.
PIRiB71231.

Genome annotation databases

EnsemblBacteriaiBAA29177; BAA29177; BAA29177.
KEGGipho:PH0108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29177.1.
PIRiB71231.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E1BX-ray2.70A1-216[»]
ProteinModelPortaliO57848.
SMRiO57848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29177; BAA29177; BAA29177.
KEGGipho:PH0108.

Phylogenomic databases

eggNOGiarCOG01254. Archaea.
COG2872. LUCA.
HOGENOMiHOG000230779.
KOiK01872.
OMAiVWHVVAE.

Enzyme and pathway databases

BRENDAi3.1.1.29. 5244.

Miscellaneous databases

EvolutionaryTraceiO57848.

Family and domain databases

InterProiIPR018165. Ala-tRNA-synth_IIc_core.
IPR018164. Ala-tRNA-synth_IIc_N.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR009000. Transl_B-barrel.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF01411. tRNA-synt_2c. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF55186. SSF55186. 1 hit.
PROSITEiPS50860. AA_TRNA_LIGASE_II_ALA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALAXM_PYRHO
AccessioniPrimary (citable) accession number: O57848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.