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O57840 (ALF1_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fba
Ordered Locus Names:PH0082
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulation

Activated by citrate By similarity.

Subunit structure

Homooctamer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the DeoC/FbaB aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Fructose-bisphosphate aldolase class 1
PRO_0000138950

Sites

Active site1911Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
O57840 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 9AB0E4501E983068

FASTA28131,189
        10         20         30         40         50         60 
MEALQNLGIR RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPKV IIRKVVRAGI 

        70         80         90        100        110        120 
DGVMMLPGIA RIAGDEVKPD VGLMIKLTSK TNLRPKPDQL LQSQLAYVED AIKLGADAIA 

       130        140        150        160        170        180 
ATVYWGSPQE DTMIRQFAEI ASYAHDLGYP VVQFAYPRGP YIDEKYGKKE DYRVVMYGAR 

       190        200        210        220        230        240 
AAAESGADMI KTYWTGSKET FAKVVEAAAG VPVLMSGGAK TDNPLDFLKV VWEVIEAGGS 

       250        260        270        280 
GAVVGRNIFQ RENPESMIRA LIRVIHRNED PEEAAKAEGL I 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000001 Genomic DNA. Translation: BAA29151.1.
PIRH71227.
RefSeqNP_142099.1. NC_000961.1.

3D structure databases

ProteinModelPortalO57840.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING70601.PH0082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA29151; BAA29151; BAA29151.
GeneID1443984.
KEGGpho:PH0082.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1830.
HOGENOMHOG000224790.
KOK11645.
OMARVIHRNE.
ProtClustDBPRK07226.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-85-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFPIRSF038992. Aldolase_Ia. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALF1_PYRHO
AccessionPrimary (citable) accession number: O57840
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families