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O57840

- ALF1_PYRHO

UniProt

O57840 - ALF1_PYRHO

Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Enzyme regulationi

    Activated by citrate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-PBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciPHOR70601:GJWR-85-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolase
    Gene namesi
    Name:fba
    Ordered Locus Names:PH0082
    OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    Taxonomic identifieri70601 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000752: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Fructose-bisphosphate aldolase class 1PRO_0000138950Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi70601.PH0082.

    Structurei

    3D structure databases

    ProteinModelPortaliO57840.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG1830.
    HOGENOMiHOG000224790.
    KOiK11645.
    OMAiATEGEYI.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view]
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O57840-1 [UniParc]FASTAAdd to Basket

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    MEALQNLGIR RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPKV    50
    IIRKVVRAGI DGVMMLPGIA RIAGDEVKPD VGLMIKLTSK TNLRPKPDQL 100
    LQSQLAYVED AIKLGADAIA ATVYWGSPQE DTMIRQFAEI ASYAHDLGYP 150
    VVQFAYPRGP YIDEKYGKKE DYRVVMYGAR AAAESGADMI KTYWTGSKET 200
    FAKVVEAAAG VPVLMSGGAK TDNPLDFLKV VWEVIEAGGS GAVVGRNIFQ 250
    RENPESMIRA LIRVIHRNED PEEAAKAEGL I 281
    Length:281
    Mass (Da):31,189
    Last modified:August 1, 1998 - v1
    Checksum:i9AB0E4501E983068
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29151.1.
    PIRiH71227.
    RefSeqiNP_142099.1. NC_000961.1.

    Genome annotation databases

    EnsemblBacteriaiBAA29151; BAA29151; BAA29151.
    GeneIDi1443984.
    KEGGipho:PH0082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000001 Genomic DNA. Translation: BAA29151.1 .
    PIRi H71227.
    RefSeqi NP_142099.1. NC_000961.1.

    3D structure databases

    ProteinModelPortali O57840.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 70601.PH0082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA29151 ; BAA29151 ; BAA29151 .
    GeneIDi 1443984.
    KEGGi pho:PH0082.

    Phylogenomic databases

    eggNOGi COG1830.
    HOGENOMi HOG000224790.
    KOi K11645.
    OMAi ATEGEYI.

    Enzyme and pathway databases

    BioCyci PHOR70601:GJWR-85-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view ]
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

    Entry informationi

    Entry nameiALF1_PYRHO
    AccessioniPrimary (citable) accession number: O57840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3