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O57840

- ALF1_PYRHO

UniProt

O57840 - ALF1_PYRHO

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Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulationi

Activated by citrate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-PBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-85-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fba
Ordered Locus Names:PH0082
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000000752: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Fructose-bisphosphate aldolase class 1PRO_0000138950Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0082.

Structurei

3D structure databases

ProteinModelPortaliO57840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family.Curated

Phylogenomic databases

eggNOGiCOG1830.
HOGENOMiHOG000224790.
KOiK11645.
OMAiATEGEYI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

Sequencei

Sequence statusi: Complete.

O57840-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEALQNLGIR RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPKV
60 70 80 90 100
IIRKVVRAGI DGVMMLPGIA RIAGDEVKPD VGLMIKLTSK TNLRPKPDQL
110 120 130 140 150
LQSQLAYVED AIKLGADAIA ATVYWGSPQE DTMIRQFAEI ASYAHDLGYP
160 170 180 190 200
VVQFAYPRGP YIDEKYGKKE DYRVVMYGAR AAAESGADMI KTYWTGSKET
210 220 230 240 250
FAKVVEAAAG VPVLMSGGAK TDNPLDFLKV VWEVIEAGGS GAVVGRNIFQ
260 270 280
RENPESMIRA LIRVIHRNED PEEAAKAEGL I
Length:281
Mass (Da):31,189
Last modified:August 1, 1998 - v1
Checksum:i9AB0E4501E983068
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29151.1.
PIRiH71227.
RefSeqiNP_142099.1. NC_000961.1.

Genome annotation databases

EnsemblBacteriaiBAA29151; BAA29151; BAA29151.
GeneIDi1443984.
KEGGipho:PH0082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29151.1 .
PIRi H71227.
RefSeqi NP_142099.1. NC_000961.1.

3D structure databases

ProteinModelPortali O57840.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 70601.PH0082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA29151 ; BAA29151 ; BAA29151 .
GeneIDi 1443984.
KEGGi pho:PH0082.

Phylogenomic databases

eggNOGi COG1830.
HOGENOMi HOG000224790.
KOi K11645.
OMAi ATEGEYI.

Enzyme and pathway databases

BioCyci PHOR70601:GJWR-85-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view ]
Pfami PF01791. DeoC. 1 hit.
[Graphical view ]
PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Entry informationi

Entry nameiALF1_PYRHO
AccessioniPrimary (citable) accession number: O57840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3